Preeclampsia, Natural History, Genes, and miRNAs Associated with the Syndrome

Laura Parada-Niño, Luisa Fernanda Castillo-León, Adrien Morel

Research output: Contribution to journalReview articlepeer-review

8 Scopus citations

Abstract

Preeclampsia (PE) is a hypertensive disease that affects pregnant women after 20 weeks of gestation. This disease is associated with an important risk of maternal and fetal mortality. PE is described as a placental pathology because, after delivery, most women recover normal arterial pressure. Poor invasion of the spiral arteries is a phenomenon well described in PE; this leads to a hypoxic uterine bed and imbalance of antiangiogenic and proangiogenic factors in the uteroplacental region, which in turn triggers the disease phenotype. The causes of the pathology are unclear; nevertheless, numerous approaches, including next-generation sequencing, association, and case control and miRNA studies, have shed light on the genetic/molecular basis of PE. These studies help us better understand the disease to advance new treatment strategies.

Original languageEnglish (US)
Article number3851225
Pages (from-to)1-12
Number of pages12
JournalJournal of Pregnancy
Volume2022
DOIs
StatePublished - 2022

All Science Journal Classification (ASJC) codes

  • Obstetrics and Gynecology

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