Preeclampsia, Natural History, Genes, and miRNAs Associated with the Syndrome

Laura Parada-Niño, Luisa Fernanda Castillo-León, Adrien Morel

Producción científica: Contribución a una revistaArtículo de revisiónrevisión exhaustiva

9 Citas (Scopus)

Resumen

Preeclampsia (PE) is a hypertensive disease that affects pregnant women after 20 weeks of gestation. This disease is associated with an important risk of maternal and fetal mortality. PE is described as a placental pathology because, after delivery, most women recover normal arterial pressure. Poor invasion of the spiral arteries is a phenomenon well described in PE; this leads to a hypoxic uterine bed and imbalance of antiangiogenic and proangiogenic factors in the uteroplacental region, which in turn triggers the disease phenotype. The causes of the pathology are unclear; nevertheless, numerous approaches, including next-generation sequencing, association, and case control and miRNA studies, have shed light on the genetic/molecular basis of PE. These studies help us better understand the disease to advance new treatment strategies.

Idioma originalInglés estadounidense
Número de artículo3851225
Páginas (desde-hasta)1-12
Número de páginas12
PublicaciónJournal of Pregnancy
Volumen2022
DOI
EstadoPublicada - 2022

Áreas temáticas de ASJC Scopus

  • Ginecología y obstetricia

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