New insights into the taxonomy of autoimmune diseases based on polyautoimmunity

Manuel Rojas, Carolina Ramírez-Santana, Yeny Acosta-Ampudia, Diana M. Monsalve, Mónica Rodriguez-Jimenez, Elizabeth Zapata, Angie Naranjo-Pulido, Ana Suárez-Avellaneda, Lady J. Ríos-Serna, Carolina Prieto, William Zambrano-Romero, María Alejandra Valero, Yhojan Rodríguez, Rubén D. Mantilla, Chengsong Zhu, Quan Zhen Li, Carlos Enrique Toro-Gutiérrez, Gabriel J. Tobón, Juan Manuel Anaya

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: The clinical coexistence of two or more autoimmune diseases (ADs) fulfilling classification criteria is termed “overt polyautoimmunity” (PolyA), whereas the presence of autoantibodies unrelated to an index AD, without clinical criteria fulfillment, is known as “latent PolyA”. We aimed to explore a new taxonomy of ADs based on PolyA. Methods: In a cross-sectional study of 292 subjects, we evaluated the presence of PolyA in 146, 45, 29, 17, and 17 patients with rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), Sjögren's syndrome (SS), autoimmune thyroid disease (AITD) and systemic sclerosis (SSc), respectively, and 38 healthy controls. Clinical assessment, autoantibody profile (by autoantigen array chip), lymphocytes immunophenotype and cytokine profile (by flow cytometry) were evaluated simultaneously. A mixed cluster methodology was used to classify ADs. Results: Latent PolyA was more frequent than overt PolyA, ranging from 69.9% in RA to 100% in SSc. Nevertheless, both latent and overt PolyA clustered together. Over-expressed IgG autoantibodies were found to be hallmarks for the identification of index ADs. The combination of autoantibodies allowed high accuracy in the classification of ADs. Three well-defined clusters based on PolyA were observed with distinctive clinical and immunological phenotypes. Conclusions: This proof-of-concept study indicates that ADs can be classified according to PolyA. PolyA should be considered in all studies dealing with ADs, including epidemiological, genetic, and clinical trials.

Original languageEnglish (US)
Article number102780
JournalJournal of Autoimmunity
Volume126
DOIs
StatePublished - Jan 2022

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

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