Kawasaki disease in Colombia: A systematic review and contrast with multisystem inflammatory syndrome in children associated with COVID-19

Kevin Llinás-Caballero; Yhojan Alexis Rodriguez Velandia; Jaime Fernández-Sarmiento; Monica Maria Del Pilar Rodriguez Jimenez; Juan-Manuel Anaya

doi:10.1016/j.rcreu.2020.11.004

Kawasaki disease in Colombia: A systematic review and contrast with multisystem inflammatory syndrome in children associated with COVID-19

Título traducido de la contribución: Enfermedad de Kawasaki en Colombia: revisión sistemática y contraste con el síndrome inflamatorio multisistémico en niños asociado a COVID-19

Kevin Llinás-Caballero, Yhojan Alexis Rodriguez Velandia, Jaime Fernández-Sarmiento, Monica Maria Del Pilar Rodriguez Jimenez, Juan-Manuel Anaya

Producción científica: Contribución a una revista › Artículo de revisión › revisión exhaustiva

7 Citas (Scopus)

Resumen

Introducción
La enfermedad de Kawasaki (EK) es una vasculitis aguda con compromiso multisistémico. Recientemente, la incidencia creciente de una condición que se asemeja en forma considerable a la EK en muchos casos, denominada síndrome inflamatorio multisistémico (SIMS) en niños, ha encendido las alarmas en medio de la actual pandemia mundial de la enfermedad COVID-19. Por consiguiente, nos propusimos realizar una revisión sistemática de la literatura acerca de la EK en Colombia y contrastarla con el SIMS relacionado con COVID-19 en niños.

Materiales y métodos
Buscamos publicaciones respecto a pacientes con EK en población colombiana, en bases de datos electrónicas tanto internacionales como latinoamericanas. Los registros hallados fueron tamizados por títulos o resúmenes, evaluados para elegibilidad y revisados. Se siguieron las guías Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA). Posteriormente, buscamos estudios que reportaran SIMS temporalmente asociado con COVID-19 en niños y comparamos estos pacientes con nuestros hallazgos de EK en Colombia.

Resultados
De 36 publicaciones encontradas se incluyeron 17, las cuales representaron 120 individuos. La razón hombre a mujer fue de 1,6 y la mayoría de los pacientes (90,4%) tenía 5 años o menos. Entre las principales características de EK, la fiebre fue la más frecuente (96,2%), mientras que la linfadenopatía cervical estuvo presente solo en el 40,6%. La inmunoglobulina intravenosa se administró en el 91,4% de los casos y 6,2% presentaron resistencia. Se encontró compromiso cardiaco en alrededor del 30% de los pacientes, en tanto que el 20% tuvo lesiones de arterias coronarias. La comparación entre las características clínicas de la EK y el SIMS asociado a COVID-19 mostró que los individuos afectados por el SIMS eran mayores (72,2% con SIMS tenían más de cinco años), tuvieron mayores índices de compromiso cardiaco y requirieron cuidado crítico con mayor frecuencia.

Conclusiones
Nuestros hallazgos de EK en Colombia son consistentes con las descripciones disponibles de esta enfermedad en la literatura científica. Debido al aumento de infección por SARS-CoV-2 en Colombia y Latinoamérica, nuestro estudio busca crear conciencia sobre el SIMS en pacientes pediátricos con COVID-19 y su relación con la EK.

Título traducido de la contribución	Enfermedad de Kawasaki en Colombia: revisión sistemática y contraste con el síndrome inflamatorio multisistémico en niños asociado a COVID-19
Idioma original	Inglés estadounidense
Número de artículo	S1
Páginas (desde-hasta)	S66-S76
Número de páginas	10
Publicación	Revista Colombiana de Reumatologia
Volumen	29
N.º	1
DOI	https://doi.org/10.1016/j.rcreu.2020.11.004
Estado	Publicada - jun. 2022

Áreas temáticas de ASJC Scopus

Reumatología

ODS de las Naciones Unidas

Este resultado contribuye a los siguientes Objetivos de Desarrollo Sostenible

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10.1016/j.rcreu.2020.11.004

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Llinás-Caballero, K., Rodriguez Velandia, Y. A., Fernández-Sarmiento, J., Rodriguez Jimenez, M. M. D. P., & Anaya, J.-M. (2022). Kawasaki disease in Colombia: A systematic review and contrast with multisystem inflammatory syndrome in children associated with COVID-19. Revista Colombiana de Reumatologia, 29(1), S66-S76. Artículo S1. https://doi.org/10.1016/j.rcreu.2020.11.004

@article{317b52d1874f4dd596b7374717d6b84a,

title = "Kawasaki disease in Colombia: A systematic review and contrast with multisystem inflammatory syndrome in children associated with COVID-19",

abstract = "IntroductionKawasaki disease (KD) is an acute vasculitis with multisystem involvement. Recently, the increasing incidence of a condition that closely resembles KD in many cases, named multisystem inflammatory syndrome in children (MIS-C), has set off alarms amid the current worldwide coronavirus disease-19 (COVID-19) pandemic. Hence, the aim is to conduct a systematic review of the literature about KD in Colombia and contrast it with COVID-19-related MIS-C.Materials and methodsA search was carried out in both international and Latin American electronic databases for publications concerning patients with KD in the Colombian population. Records were then screened by titles and/or abstracts, assessed for eligibility, and reviewed. Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines were followed. The search included studies reporting MIS-C associated with COVID-19, and compared these patients with our findings of KD in Colombia.ResultsOut of 36 publications retrieved, 17 were included, representing 120 individuals. Male to female ratio was 1.6, and most patients (90.4%) were aged 5 years or less. Among the main features of KD, fever was the most frequent (96.2% of the patients), while cervical lymphadenopathy was present in only 40.6%. Intravenous immunoglobulin was administered in 91.4% cases and 6.2% were resistant. Cardiac involvement was found in around 30%, and 20% had coronary artery lesions. Comparison between MIS-C associated with COVID-19 and KD in Colombia indicates that patients affected by MIS-C were older (72.2% of MIS-C patients > 5 years), had higher rates of cardiac involvement, and required critical care more often.ConclusionsOur findings of KD in Colombia are consistent with the available descriptions of KD in the scientific literature. Given the increasing rate of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection in Colombia and Latin America, our study raises awareness about MIS-C in pediatric patients with COVID-19 and its relationship with KD.",

author = "Kevin Llin{\'a}s-Caballero and {Rodriguez Velandia}, {Yhojan Alexis} and Jaime Fern{\'a}ndez-Sarmiento and {Rodriguez Jimenez}, {Monica Maria Del Pilar} and Juan-Manuel Anaya",

note = "Funding Information: This work was supported by Universidad del Rosario, Bogota, Colombia ( ABN-011 ). Publisher Copyright: {\textcopyright} 2021 Asociaci{\'o}n Colombiana de Reumatolog{\'i}a",

year = "2022",

month = jun,

doi = "10.1016/j.rcreu.2020.11.004",

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volume = "29",

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Kawasaki disease in Colombia: A systematic review and contrast with multisystem inflammatory syndrome in children associated with COVID-19. / Llinás-Caballero, Kevin; Rodriguez Velandia, Yhojan Alexis; Fernández-Sarmiento, Jaime et al.
En: Revista Colombiana de Reumatologia, Vol. 29, N.º 1, S1, 06.2022, p. S66-S76.

Producción científica: Contribución a una revista › Artículo de revisión › revisión exhaustiva

TY - JOUR

T1 - Kawasaki disease in Colombia: A systematic review and contrast with multisystem inflammatory syndrome in children associated with COVID-19

AU - Llinás-Caballero, Kevin

AU - Rodriguez Velandia, Yhojan Alexis

AU - Fernández-Sarmiento, Jaime

AU - Rodriguez Jimenez, Monica Maria Del Pilar

AU - Anaya, Juan-Manuel

PY - 2022/6

Y1 - 2022/6

N2 - IntroductionKawasaki disease (KD) is an acute vasculitis with multisystem involvement. Recently, the increasing incidence of a condition that closely resembles KD in many cases, named multisystem inflammatory syndrome in children (MIS-C), has set off alarms amid the current worldwide coronavirus disease-19 (COVID-19) pandemic. Hence, the aim is to conduct a systematic review of the literature about KD in Colombia and contrast it with COVID-19-related MIS-C.Materials and methodsA search was carried out in both international and Latin American electronic databases for publications concerning patients with KD in the Colombian population. Records were then screened by titles and/or abstracts, assessed for eligibility, and reviewed. Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines were followed. The search included studies reporting MIS-C associated with COVID-19, and compared these patients with our findings of KD in Colombia.ResultsOut of 36 publications retrieved, 17 were included, representing 120 individuals. Male to female ratio was 1.6, and most patients (90.4%) were aged 5 years or less. Among the main features of KD, fever was the most frequent (96.2% of the patients), while cervical lymphadenopathy was present in only 40.6%. Intravenous immunoglobulin was administered in 91.4% cases and 6.2% were resistant. Cardiac involvement was found in around 30%, and 20% had coronary artery lesions. Comparison between MIS-C associated with COVID-19 and KD in Colombia indicates that patients affected by MIS-C were older (72.2% of MIS-C patients > 5 years), had higher rates of cardiac involvement, and required critical care more often.ConclusionsOur findings of KD in Colombia are consistent with the available descriptions of KD in the scientific literature. Given the increasing rate of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection in Colombia and Latin America, our study raises awareness about MIS-C in pediatric patients with COVID-19 and its relationship with KD.

AB - IntroductionKawasaki disease (KD) is an acute vasculitis with multisystem involvement. Recently, the increasing incidence of a condition that closely resembles KD in many cases, named multisystem inflammatory syndrome in children (MIS-C), has set off alarms amid the current worldwide coronavirus disease-19 (COVID-19) pandemic. Hence, the aim is to conduct a systematic review of the literature about KD in Colombia and contrast it with COVID-19-related MIS-C.Materials and methodsA search was carried out in both international and Latin American electronic databases for publications concerning patients with KD in the Colombian population. Records were then screened by titles and/or abstracts, assessed for eligibility, and reviewed. Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines were followed. The search included studies reporting MIS-C associated with COVID-19, and compared these patients with our findings of KD in Colombia.ResultsOut of 36 publications retrieved, 17 were included, representing 120 individuals. Male to female ratio was 1.6, and most patients (90.4%) were aged 5 years or less. Among the main features of KD, fever was the most frequent (96.2% of the patients), while cervical lymphadenopathy was present in only 40.6%. Intravenous immunoglobulin was administered in 91.4% cases and 6.2% were resistant. Cardiac involvement was found in around 30%, and 20% had coronary artery lesions. Comparison between MIS-C associated with COVID-19 and KD in Colombia indicates that patients affected by MIS-C were older (72.2% of MIS-C patients > 5 years), had higher rates of cardiac involvement, and required critical care more often.ConclusionsOur findings of KD in Colombia are consistent with the available descriptions of KD in the scientific literature. Given the increasing rate of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection in Colombia and Latin America, our study raises awareness about MIS-C in pediatric patients with COVID-19 and its relationship with KD.

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Kawasaki disease in Colombia: A systematic review and contrast with multisystem inflammatory syndrome in children associated with COVID-19

Resumen

Áreas temáticas de ASJC Scopus

ODS de las Naciones Unidas

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