A renin-like enzyme in luteal tissue

R. R. Cabrera; D. C. Guardia; E. De Vito

doi:10.1016/0303-7207(86)90120-6

A renin-like enzyme in luteal tissue

R. R. Cabrera, D. C. Guardia, E. De Vito

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14 Citas (Scopus)

Resumen

The aim of this study was to identify immunologically and biologically a renin-like enzyme (RLE) in rat corpora lutea (CL). The biological activity of partially purified extracts of CL was tested in vivo by injection into anesthetized pentolinium-treated rats, obtaining a pressor response similar to renal renin. The enzyme activity in vitro was inhibited to about 50% by pretreatment with a specific antibody against renal renin. When the extracts were incubated with angiotensinogen, the product was inhibited mainly by angiotensin I antibody. The fact that there was no change in RLE content in 24 or 48 h nephrectomized rats, suggested the idea of a local production rather than an active blood renin sequestration.

Idioma original	Inglés estadounidense
Páginas (desde-hasta)	269-273
Número de páginas	5
Publicación	Molecular and Cellular Endocrinology
Volumen	47
N.º	3
DOI	https://doi.org/10.1016/0303-7207(86)90120-6
Estado	Publicada - oct. 1986
Publicado de forma externa	Sí

Áreas temáticas de ASJC Scopus

Bioquímica
Biología molecular
Endocrinología

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10.1016/0303-7207(86)90120-6

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title = "A renin-like enzyme in luteal tissue",

abstract = "The aim of this study was to identify immunologically and biologically a renin-like enzyme (RLE) in rat corpora lutea (CL). The biological activity of partially purified extracts of CL was tested in vivo by injection into anesthetized pentolinium-treated rats, obtaining a pressor response similar to renal renin. The enzyme activity in vitro was inhibited to about 50% by pretreatment with a specific antibody against renal renin. When the extracts were incubated with angiotensinogen, the product was inhibited mainly by angiotensin I antibody. The fact that there was no change in RLE content in 24 or 48 h nephrectomized rats, suggested the idea of a local production rather than an active blood renin sequestration.",

author = "Cabrera, {R. R.} and Guardia, {D. C.} and {De Vito}, E.",

note = "Funding Information: This work was supported by a grant from the BID-CONICET Program.",

year = "1986",

month = oct,

doi = "10.1016/0303-7207(86)90120-6",

language = "English (US)",

volume = "47",

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T1 - A renin-like enzyme in luteal tissue

AU - Cabrera, R. R.

AU - Guardia, D. C.

AU - De Vito, E.

N1 - Funding Information: This work was supported by a grant from the BID-CONICET Program.

PY - 1986/10

Y1 - 1986/10

N2 - The aim of this study was to identify immunologically and biologically a renin-like enzyme (RLE) in rat corpora lutea (CL). The biological activity of partially purified extracts of CL was tested in vivo by injection into anesthetized pentolinium-treated rats, obtaining a pressor response similar to renal renin. The enzyme activity in vitro was inhibited to about 50% by pretreatment with a specific antibody against renal renin. When the extracts were incubated with angiotensinogen, the product was inhibited mainly by angiotensin I antibody. The fact that there was no change in RLE content in 24 or 48 h nephrectomized rats, suggested the idea of a local production rather than an active blood renin sequestration.

AB - The aim of this study was to identify immunologically and biologically a renin-like enzyme (RLE) in rat corpora lutea (CL). The biological activity of partially purified extracts of CL was tested in vivo by injection into anesthetized pentolinium-treated rats, obtaining a pressor response similar to renal renin. The enzyme activity in vitro was inhibited to about 50% by pretreatment with a specific antibody against renal renin. When the extracts were incubated with angiotensinogen, the product was inhibited mainly by angiotensin I antibody. The fact that there was no change in RLE content in 24 or 48 h nephrectomized rats, suggested the idea of a local production rather than an active blood renin sequestration.

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DO - 10.1016/0303-7207(86)90120-6

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AN - SCOPUS:0022886542

SN - 0303-7207

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JO - Molecular and Cellular Endocrinology

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A renin-like enzyme in luteal tissue

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