A renin-like enzyme in luteal tissue

R. R. Cabrera, D. C. Guardia, E. De Vito

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


The aim of this study was to identify immunologically and biologically a renin-like enzyme (RLE) in rat corpora lutea (CL). The biological activity of partially purified extracts of CL was tested in vivo by injection into anesthetized pentolinium-treated rats, obtaining a pressor response similar to renal renin. The enzyme activity in vitro was inhibited to about 50% by pretreatment with a specific antibody against renal renin. When the extracts were incubated with angiotensinogen, the product was inhibited mainly by angiotensin I antibody. The fact that there was no change in RLE content in 24 or 48 h nephrectomized rats, suggested the idea of a local production rather than an active blood renin sequestration.

Original languageEnglish (US)
Pages (from-to)269-273
Number of pages5
JournalMolecular and Cellular Endocrinology
Issue number3
StatePublished - Oct 1986
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Endocrinology


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