Pathophysiological mechanisms of cognitive impairment and neurodegeneration by Toxoplasma gondii infection

Gloria Ortiz‐Guerrero, Rodrigo E. Gonzalez‐Reyes, Alejandra De‐la‐torre, German Medina‐Rincón, Mauricio O. Nava‐Mesa

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

Toxoplasma gondii is an obligate intracellular parasite considered one of the most successful pathogens in the world, owing to its ability to produce long‐lasting infections and to persist in the central nervous system (CNS) in most warm‐blooded animals, including humans. This parasite has a preference to invade neurons and affect the functioning of glial cells. This could lead to neurological and behavioral changes associated with cognitive impairment. Although several studies in humans and animal models have reported controversial results about the relationship between toxoplasmosis and the onset of dementia as a causal factor, two recent meta‐analyses have shown a relative association with Alzheimer’s disease (AD). AD is characterized by amyloid‐β (Aβ) peptide accumulation, neurofibrillary tangles, and neuroinflammation. Different authors have found that toxoplasmosis may affect Aβ production in brain areas linked with memory functioning, and can induce a central immune response and neurotransmitter imbalance, which in turn, affect the nervous system microenvironment. In contrast, other studies have revealed a reduction of Aβ plaques and hyperphosphorylated tau protein formation in animal models, which might cause some protective effects. The aim of this article is to summarize and review the newest data in regard to different pathophysiological mechanisms of cerebral toxoplasmosis and their relationship with the development of AD and cognitive impairment. All these associations should be investigated further through clinical and experimental studies.

Translated title of the contributionMecanismos fisiopatologicos del deterioro cognitivo y la neurodegeneracion por Toxoplasma gondii
Original languageEnglish (US)
Article number369
Pages (from-to)1-19
Number of pages19
JournalBrain Sciences
Volume10
Issue number6
DOIs
StatePublished - Jun 12 2020

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Fingerprint Dive into the research topics of 'Pathophysiological mechanisms of cognitive impairment and neurodegeneration by Toxoplasma gondii infection'. Together they form a unique fingerprint.

Cite this