TY - JOUR
T1 - Novel taxa of thermally dimorphic systemic pathogens in the Ajellomycetaceae (Onygenales)
AU - Dukik, Karolina
AU - Muñoz, Jose F.
AU - Jiang, Yanping
AU - Feng, Peiying
AU - Sigler, Lynne
AU - Stielow, J. Benjamin
AU - Freeke, Joanna
AU - Jamalian, Azadeh
AU - Gerrits van den Ende, Bert
AU - McEwen Ochoa, Juan Guillermo
AU - Clay, Oliver K.
AU - Schwartz, Ilan S.
AU - Govender, Nelesh P.
AU - Maphanga, Tsidiso G.
AU - Cuomo, Christina A.
AU - Moreno, Leandro F.
AU - Kenyon, Chris
AU - Borman, Andrew M.
AU - de Hoog, Sybren
PY - 2017/5/1
Y1 - 2017/5/1
N2 - Recent discoveries of novel systemic fungal pathogens with thermally dimorphic yeast-like phases have challenged the current taxonomy of the Ajellomycetaceae, a family currently comprising the genera Blastomyces, Emmonsia, Emmonsiellopsis, Helicocarpus, Histoplasma, Lacazia and Paracoccidioides. Our morphological, phylogenetic and phylogenomic analyses demonstrated species relationships and their specific phenotypes, clarified generic boundaries and provided the first annotated genome assemblies to support the description of two new species. A new genus, Emergomyces, accommodates Emmonsia pasteuriana as type species, and the new species Emergomyces africanus, the aetiological agent of case series of disseminated infections in South Africa. Both species produce small yeast cells that bud at a narrow base at 37°C and lack adiaspores, classically associated with the genus Emmonsia. Another novel dimorphic pathogen, producing broad-based budding cells at 37°C and occurring outside North America, proved to belong to the genus Blastomyces, and is described as Blastomyces percursus.
AB - Recent discoveries of novel systemic fungal pathogens with thermally dimorphic yeast-like phases have challenged the current taxonomy of the Ajellomycetaceae, a family currently comprising the genera Blastomyces, Emmonsia, Emmonsiellopsis, Helicocarpus, Histoplasma, Lacazia and Paracoccidioides. Our morphological, phylogenetic and phylogenomic analyses demonstrated species relationships and their specific phenotypes, clarified generic boundaries and provided the first annotated genome assemblies to support the description of two new species. A new genus, Emergomyces, accommodates Emmonsia pasteuriana as type species, and the new species Emergomyces africanus, the aetiological agent of case series of disseminated infections in South Africa. Both species produce small yeast cells that bud at a narrow base at 37°C and lack adiaspores, classically associated with the genus Emmonsia. Another novel dimorphic pathogen, producing broad-based budding cells at 37°C and occurring outside North America, proved to belong to the genus Blastomyces, and is described as Blastomyces percursus.
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U2 - 10.1111/myc.12601
DO - 10.1111/myc.12601
M3 - Research Article
C2 - 28176377
AN - SCOPUS:85013178139
SN - 0933-7407
VL - 60
SP - 296
EP - 309
JO - Mycoses
JF - Mycoses
IS - 5
ER -