Novel taxa of thermally dimorphic systemic pathogens in the Ajellomycetaceae (Onygenales)

Karolina Dukik, Jose F. Muñoz, Yanping Jiang, Peiying Feng, Lynne Sigler, J. Benjamin Stielow, Joanna Freeke, Azadeh Jamalian, Bert Gerrits van den Ende, Juan Guillermo McEwen Ochoa, Oliver K. Clay, Ilan S. Schwartz, Nelesh P. Govender, Tsidiso G. Maphanga, Christina A. Cuomo, Leandro F. Moreno, Chris Kenyon, Andrew M. Borman, Sybren de Hoog

Resultado de la investigación: Contribución a una revistaArtículo

51 Citas (Scopus)

Resumen

Recent discoveries of novel systemic fungal pathogens with thermally dimorphic yeast-like phases have challenged the current taxonomy of the Ajellomycetaceae, a family currently comprising the genera Blastomyces, Emmonsia, Emmonsiellopsis, Helicocarpus, Histoplasma, Lacazia and Paracoccidioides. Our morphological, phylogenetic and phylogenomic analyses demonstrated species relationships and their specific phenotypes, clarified generic boundaries and provided the first annotated genome assemblies to support the description of two new species. A new genus, Emergomyces, accommodates Emmonsia pasteuriana as type species, and the new species Emergomyces africanus, the aetiological agent of case series of disseminated infections in South Africa. Both species produce small yeast cells that bud at a narrow base at 37°C and lack adiaspores, classically associated with the genus Emmonsia. Another novel dimorphic pathogen, producing broad-based budding cells at 37°C and occurring outside North America, proved to belong to the genus Blastomyces, and is described as Blastomyces percursus.

Idioma originalInglés estadounidense
Páginas (desde-hasta)296-309
Número de páginas14
PublicaciónMycoses
Volumen60
N.º5
DOI
EstadoPublicada - may 1 2017

    Huella digital

All Science Journal Classification (ASJC) codes

  • Dermatología
  • Enfermedades infecciosas

Citar esto

Dukik, K., Muñoz, J. F., Jiang, Y., Feng, P., Sigler, L., Stielow, J. B., Freeke, J., Jamalian, A., Gerrits van den Ende, B., McEwen Ochoa, J. G., Clay, O. K., Schwartz, I. S., Govender, N. P., Maphanga, T. G., Cuomo, C. A., Moreno, L. F., Kenyon, C., Borman, A. M., & de Hoog, S. (2017). Novel taxa of thermally dimorphic systemic pathogens in the Ajellomycetaceae (Onygenales). Mycoses, 60(5), 296-309. https://doi.org/10.1111/myc.12601