Novel taxa of thermally dimorphic systemic pathogens in the Ajellomycetaceae (Onygenales)

Karolina Dukik, Jose F. Muñoz, Yanping Jiang, Peiying Feng, Lynne Sigler, J. Benjamin Stielow, Joanna Freeke, Azadeh Jamalian, Bert Gerrits van den Ende, Juan Guillermo McEwen Ochoa, Oliver K. Clay, Ilan S. Schwartz, Nelesh P. Govender, Tsidiso G. Maphanga, Christina A. Cuomo, Leandro F. Moreno, Chris Kenyon, Andrew M. Borman, Sybren de Hoog

Resultado de la investigación: Contribución a RevistaArtículo

40 Citas (Scopus)

Resumen

Recent discoveries of novel systemic fungal pathogens with thermally dimorphic yeast-like phases have challenged the current taxonomy of the Ajellomycetaceae, a family currently comprising the genera Blastomyces, Emmonsia, Emmonsiellopsis, Helicocarpus, Histoplasma, Lacazia and Paracoccidioides. Our morphological, phylogenetic and phylogenomic analyses demonstrated species relationships and their specific phenotypes, clarified generic boundaries and provided the first annotated genome assemblies to support the description of two new species. A new genus, Emergomyces, accommodates Emmonsia pasteuriana as type species, and the new species Emergomyces africanus, the aetiological agent of case series of disseminated infections in South Africa. Both species produce small yeast cells that bud at a narrow base at 37°C and lack adiaspores, classically associated with the genus Emmonsia. Another novel dimorphic pathogen, producing broad-based budding cells at 37°C and occurring outside North America, proved to belong to the genus Blastomyces, and is described as Blastomyces percursus.

Idioma originalEnglish (US)
Páginas (desde-hasta)296-309
Número de páginas14
PublicaciónMycoses
Volumen60
N.º5
DOI
EstadoPublished - may 1 2017

Huella dactilar

Onygenales
Chrysosporium
Blastomyces
Lacazia
Yeasts
Paracoccidioides
Histoplasma
North America
South Africa
Genome
Phenotype
Infection

All Science Journal Classification (ASJC) codes

  • Dermatology
  • Infectious Diseases

Citar esto

Dukik, K., Muñoz, J. F., Jiang, Y., Feng, P., Sigler, L., Stielow, J. B., ... de Hoog, S. (2017). Novel taxa of thermally dimorphic systemic pathogens in the Ajellomycetaceae (Onygenales). Mycoses, 60(5), 296-309. https://doi.org/10.1111/myc.12601
Dukik, Karolina ; Muñoz, Jose F. ; Jiang, Yanping ; Feng, Peiying ; Sigler, Lynne ; Stielow, J. Benjamin ; Freeke, Joanna ; Jamalian, Azadeh ; Gerrits van den Ende, Bert ; McEwen Ochoa, Juan Guillermo ; Clay, Oliver K. ; Schwartz, Ilan S. ; Govender, Nelesh P. ; Maphanga, Tsidiso G. ; Cuomo, Christina A. ; Moreno, Leandro F. ; Kenyon, Chris ; Borman, Andrew M. ; de Hoog, Sybren. / Novel taxa of thermally dimorphic systemic pathogens in the Ajellomycetaceae (Onygenales). En: Mycoses. 2017 ; Vol. 60, N.º 5. pp. 296-309.
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abstract = "Recent discoveries of novel systemic fungal pathogens with thermally dimorphic yeast-like phases have challenged the current taxonomy of the Ajellomycetaceae, a family currently comprising the genera Blastomyces, Emmonsia, Emmonsiellopsis, Helicocarpus, Histoplasma, Lacazia and Paracoccidioides. Our morphological, phylogenetic and phylogenomic analyses demonstrated species relationships and their specific phenotypes, clarified generic boundaries and provided the first annotated genome assemblies to support the description of two new species. A new genus, Emergomyces, accommodates Emmonsia pasteuriana as type species, and the new species Emergomyces africanus, the aetiological agent of case series of disseminated infections in South Africa. Both species produce small yeast cells that bud at a narrow base at 37°C and lack adiaspores, classically associated with the genus Emmonsia. Another novel dimorphic pathogen, producing broad-based budding cells at 37°C and occurring outside North America, proved to belong to the genus Blastomyces, and is described as Blastomyces percursus.",
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Dukik, K, Muñoz, JF, Jiang, Y, Feng, P, Sigler, L, Stielow, JB, Freeke, J, Jamalian, A, Gerrits van den Ende, B, McEwen Ochoa, JG, Clay, OK, Schwartz, IS, Govender, NP, Maphanga, TG, Cuomo, CA, Moreno, LF, Kenyon, C, Borman, AM & de Hoog, S 2017, 'Novel taxa of thermally dimorphic systemic pathogens in the Ajellomycetaceae (Onygenales)', Mycoses, vol. 60, n.º 5, pp. 296-309. https://doi.org/10.1111/myc.12601

Novel taxa of thermally dimorphic systemic pathogens in the Ajellomycetaceae (Onygenales). / Dukik, Karolina; Muñoz, Jose F.; Jiang, Yanping; Feng, Peiying; Sigler, Lynne; Stielow, J. Benjamin; Freeke, Joanna; Jamalian, Azadeh; Gerrits van den Ende, Bert; McEwen Ochoa, Juan Guillermo; Clay, Oliver K.; Schwartz, Ilan S.; Govender, Nelesh P.; Maphanga, Tsidiso G.; Cuomo, Christina A.; Moreno, Leandro F.; Kenyon, Chris; Borman, Andrew M.; de Hoog, Sybren.

En: Mycoses, Vol. 60, N.º 5, 01.05.2017, p. 296-309.

Resultado de la investigación: Contribución a RevistaArtículo

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T1 - Novel taxa of thermally dimorphic systemic pathogens in the Ajellomycetaceae (Onygenales)

AU - Dukik, Karolina

AU - Muñoz, Jose F.

AU - Jiang, Yanping

AU - Feng, Peiying

AU - Sigler, Lynne

AU - Stielow, J. Benjamin

AU - Freeke, Joanna

AU - Jamalian, Azadeh

AU - Gerrits van den Ende, Bert

AU - McEwen Ochoa, Juan Guillermo

AU - Clay, Oliver K.

AU - Schwartz, Ilan S.

AU - Govender, Nelesh P.

AU - Maphanga, Tsidiso G.

AU - Cuomo, Christina A.

AU - Moreno, Leandro F.

AU - Kenyon, Chris

AU - Borman, Andrew M.

AU - de Hoog, Sybren

PY - 2017/5/1

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N2 - Recent discoveries of novel systemic fungal pathogens with thermally dimorphic yeast-like phases have challenged the current taxonomy of the Ajellomycetaceae, a family currently comprising the genera Blastomyces, Emmonsia, Emmonsiellopsis, Helicocarpus, Histoplasma, Lacazia and Paracoccidioides. Our morphological, phylogenetic and phylogenomic analyses demonstrated species relationships and their specific phenotypes, clarified generic boundaries and provided the first annotated genome assemblies to support the description of two new species. A new genus, Emergomyces, accommodates Emmonsia pasteuriana as type species, and the new species Emergomyces africanus, the aetiological agent of case series of disseminated infections in South Africa. Both species produce small yeast cells that bud at a narrow base at 37°C and lack adiaspores, classically associated with the genus Emmonsia. Another novel dimorphic pathogen, producing broad-based budding cells at 37°C and occurring outside North America, proved to belong to the genus Blastomyces, and is described as Blastomyces percursus.

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Dukik K, Muñoz JF, Jiang Y, Feng P, Sigler L, Stielow JB y otros. Novel taxa of thermally dimorphic systemic pathogens in the Ajellomycetaceae (Onygenales). Mycoses. 2017 may 1;60(5):296-309. https://doi.org/10.1111/myc.12601