Molecular and clinical aspects of chronic manifestations in chagas disease: A state-of-the-art review

Germán J. Medina-Rincón, Sebastián Gallo-Bernal, Paula A. Jiménez, Lissa Cruz-Saavedra, Juan David Ramírez, María Juliana Rodríguez, Ramón Medina-Mur, Gustavo Díaz-Nassif, María Daniela Valderrama-Achury, Héctor M. Medina

Research output: Contribution to journalReview articlepeer-review


Chronic manifestations of Chagas disease present as disabling and life-threatening condi-tions affecting mainly the cardiovascular and gastrointestinal systems. Although meaningful research has outlined the different molecular mechanisms underlying Trypanosoma cruzi’s infection and the host-parasite interactions that follow, prompt diagnosis and treatment remain a challenge, particu-larly in developing countries and also in those where the disease is considered non-endemic. This review intends to present an up-to-date review of the parasite’s life cycle, genetic diversity, virulence factors, and infective mechanisms, as well as the epidemiology, clinical presentation, diagnosis, and treatment options of the main chronic complications of Chagas disease.

Original languageEnglish (US)
Article number1493
Issue number11
StatePublished - Nov 2021

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Molecular Biology
  • Immunology and Microbiology(all)
  • Microbiology (medical)
  • Infectious Diseases

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