TY - JOUR
T1 - Molecular and clinical aspects of chronic manifestations in chagas disease
T2 - A state-of-the-art review
AU - Medina-Rincón, Germán J.
AU - Gallo-Bernal, Sebastián
AU - Jiménez, Paula A.
AU - Cruz-Saavedra, Lissa
AU - Ramírez, Juan David
AU - Rodríguez, María Juliana
AU - Medina-Mur, Ramón
AU - Díaz-Nassif, Gustavo
AU - Valderrama-Achury, María Daniela
AU - Medina, Héctor M.
N1 - Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2021/11
Y1 - 2021/11
N2 - Chronic manifestations of Chagas disease present as disabling and life-threatening condi-tions affecting mainly the cardiovascular and gastrointestinal systems. Although meaningful research has outlined the different molecular mechanisms underlying Trypanosoma cruzi’s infection and the host-parasite interactions that follow, prompt diagnosis and treatment remain a challenge, particu-larly in developing countries and also in those where the disease is considered non-endemic. This review intends to present an up-to-date review of the parasite’s life cycle, genetic diversity, virulence factors, and infective mechanisms, as well as the epidemiology, clinical presentation, diagnosis, and treatment options of the main chronic complications of Chagas disease.
AB - Chronic manifestations of Chagas disease present as disabling and life-threatening condi-tions affecting mainly the cardiovascular and gastrointestinal systems. Although meaningful research has outlined the different molecular mechanisms underlying Trypanosoma cruzi’s infection and the host-parasite interactions that follow, prompt diagnosis and treatment remain a challenge, particu-larly in developing countries and also in those where the disease is considered non-endemic. This review intends to present an up-to-date review of the parasite’s life cycle, genetic diversity, virulence factors, and infective mechanisms, as well as the epidemiology, clinical presentation, diagnosis, and treatment options of the main chronic complications of Chagas disease.
UR - http://www.scopus.com/inward/record.url?scp=85119699180&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85119699180&partnerID=8YFLogxK
U2 - 10.3390/pathogens10111493
DO - 10.3390/pathogens10111493
M3 - Review article
C2 - 34832648
AN - SCOPUS:85119699180
SN - 2076-0817
VL - 10
JO - Pathogens
JF - Pathogens
IS - 11
M1 - 1493
ER -
