Molecular and clinical aspects of chronic manifestations in chagas disease: A state-of-the-art review

Germán J. Medina-Rincón; Sebastián Gallo-Bernal; Paula A. Jiménez; Lissa Cruz-Saavedra; Juan David Ramírez; María Juliana Rodríguez; Ramón Medina-Mur; Gustavo Díaz-Nassif; María Daniela Valderrama-Achury; Héctor M. Medina

doi:10.3390/pathogens10111493

Molecular and clinical aspects of chronic manifestations in chagas disease: A state-of-the-art review

Germán J. Medina-Rincón, Sebastián Gallo-Bernal, Paula A. Jiménez, Lissa Cruz-Saavedra, Juan David Ramírez, María Juliana Rodríguez, Ramón Medina-Mur, Gustavo Díaz-Nassif, María Daniela Valderrama-Achury, Héctor M. Medina

Producción científica: Contribución a una revista › Artículo de revisión › revisión exhaustiva

11 Citas (Scopus)

Resumen

Chronic manifestations of Chagas disease present as disabling and life-threatening condi-tions affecting mainly the cardiovascular and gastrointestinal systems. Although meaningful research has outlined the different molecular mechanisms underlying Trypanosoma cruzi’s infection and the host-parasite interactions that follow, prompt diagnosis and treatment remain a challenge, particu-larly in developing countries and also in those where the disease is considered non-endemic. This review intends to present an up-to-date review of the parasite’s life cycle, genetic diversity, virulence factors, and infective mechanisms, as well as the epidemiology, clinical presentation, diagnosis, and treatment options of the main chronic complications of Chagas disease.

Idioma original	Inglés estadounidense
Número de artículo	1493
Publicación	Pathogens
Volumen	10
N.º	11
DOI	https://doi.org/10.3390/pathogens10111493
Estado	Publicada - nov. 2021

Áreas temáticas de ASJC Scopus

Inmulogía y alergología
Biología molecular
Inmunología y Microbiología General
Microbiología (médica)
Enfermedades infecciosas

ODS de las Naciones Unidas

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Medina-Rincón, G. J., Gallo-Bernal, S., Jiménez, P. A., Cruz-Saavedra, L., Ramírez, J. D., Rodríguez, M. J., Medina-Mur, R., Díaz-Nassif, G., Valderrama-Achury, M. D., & Medina, H. M. (2021). Molecular and clinical aspects of chronic manifestations in chagas disease: A state-of-the-art review. Pathogens, 10(11), Artículo 1493. https://doi.org/10.3390/pathogens10111493

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title = "Molecular and clinical aspects of chronic manifestations in chagas disease: A state-of-the-art review",

abstract = "Chronic manifestations of Chagas disease present as disabling and life-threatening condi-tions affecting mainly the cardiovascular and gastrointestinal systems. Although meaningful research has outlined the different molecular mechanisms underlying Trypanosoma cruzi{\textquoteright}s infection and the host-parasite interactions that follow, prompt diagnosis and treatment remain a challenge, particu-larly in developing countries and also in those where the disease is considered non-endemic. This review intends to present an up-to-date review of the parasite{\textquoteright}s life cycle, genetic diversity, virulence factors, and infective mechanisms, as well as the epidemiology, clinical presentation, diagnosis, and treatment options of the main chronic complications of Chagas disease.",

author = "Medina-Rinc{\'o}n, {Germ{\'a}n J.} and Sebasti{\'a}n Gallo-Bernal and Jim{\'e}nez, {Paula A.} and Lissa Cruz-Saavedra and Ram{\'i}rez, {Juan David} and Rodr{\'i}guez, {Mar{\'i}a Juliana} and Ram{\'o}n Medina-Mur and Gustavo D{\'i}az-Nassif and Valderrama-Achury, {Mar{\'i}a Daniela} and Medina, {H{\'e}ctor M.}",

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AU - Cruz-Saavedra, Lissa

AU - Ramírez, Juan David

AU - Rodríguez, María Juliana

AU - Medina-Mur, Ramón

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Molecular and clinical aspects of chronic manifestations in chagas disease: A state-of-the-art review

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Áreas temáticas de ASJC Scopus

ODS de las Naciones Unidas

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