Micronuclei frequency and exposure to chemical mixtures in three Colombian mining populations

Karina Pastor-Sierra; Lyda Espitia-Pérez; Pedro Espitia-Pérez; Ana Peñata-Taborda; Hugo Brango; Claudia Galeano-Páez; Osnamir Elías Bru-Cordero; Marien Palma-Parra; Sonia M. Díaz; Carlos Trillos; Leonardo Briceño; Álvaro J. Idrovo; Juan Miranda-Pacheco; Eliana Téllez; Luisa Jiménez-Vidal; Andrés Coneo-Pretelt; Alicia Humanez Álvarez; Gean Arteaga-Arroyo; Dina Ricardo-Caldera; Shirley Salcedo-Arteaga; Alexandra Porras-Ramírez; Marcela Varona-Uribe

doi:10.1016/j.scitotenv.2023.165789

Micronuclei frequency and exposure to chemical mixtures in three Colombian mining populations

Karina Pastor-Sierra, Lyda Espitia-Pérez, Pedro Espitia-Pérez, Ana Peñata-Taborda, Hugo Brango, Claudia Galeano-Páez, Osnamir Elías Bru-Cordero, Marien Palma-Parra, Sonia M. Díaz, Carlos Trillos, Leonardo Briceño, Álvaro J. Idrovo, Juan Miranda-Pacheco, Eliana Téllez, Luisa Jiménez-Vidal, Andrés Coneo-Pretelt, Alicia Humanez Álvarez, Gean Arteaga-Arroyo, Dina Ricardo-Caldera, Shirley Salcedo-ArteagaAlexandra Porras-Ramírez, Marcela Varona-Uribe

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

The Colombian mining industry has witnessed significant growth. Depending on the scale and mineral extracted, complex chemical mixtures are generated, impacting the health of occupationally exposed populations and communities near mining projects. Increasing evidence suggests that chromosomal instability (CIN) is an important link between the development of certain diseases and exposure to complex mixtures. To better understand the effects of exposure to complex mixtures we performed a biomonitoring study on 407 healthy individuals from four areas: three located in municipalities exploiting different-scale mining systems and a reference area with no mining activity. Large, medium, and small-scale mining systems were analyzed in Montelibano (Córdoba), artisanal and small-scale mining (ASGM) in Nechí (Antioquia), and a closed mining system in Aranzazu (Caldas). The reference area with no mining activity was established in Montería (Córdoba). ICP-MS measured multi-elemental exposure in hair, and CIN was evaluated using the cytokinesis-block micronucleus technique (MNBN). Exposure to mixtures of chemical elements was comparable in workers and residents of the mining areas but significantly higher compared to reference individuals. In Montelibano, increased MNBN frequencies were associated with combined exposure to Se, Hg, Mn, Pb, and Mg. This distinct pattern significantly differed from other areas. Specifically, in Nechí, Cr, Ni, Hg, Se, and Mg emerged as the primary contributors to elevated frequencies of MNBN. In contrast, a combination of Hg and Ni played a role in increasing MNBN in Aranzazu. Interestingly, Se consistently correlated with increased MNBN frequencies across all active mining areas. Chemical elements in Montelibano exhibit a broader range compared to other mining zones, reflecting the characteristics of the high-impact and large-scale mining in the area. This research provides valuable insights into the effects of exposure to chemical mixtures, underscoring the importance of employing this approach in the risk assessment of communities, especially those from residential areas.

Translated title of the contribution	Frecuencia de micronúcleos y exposición a mezclas químicas en tres poblaciones mineras colombianas
Original language	English (US)
Article number	165789
Pages (from-to)	1-19
Number of pages	19
Journal	Science of the Total Environment
Volume	901
DOIs	https://doi.org/10.1016/j.scitotenv.2023.165789
State	Published - Nov 25 2023

All Science Journal Classification (ASJC) codes

Environmental Engineering
Environmental Chemistry
Waste Management and Disposal
Pollution

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.scitotenv.2023.165789

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Pastor-Sierra, K., Espitia-Pérez, L., Espitia-Pérez, P., Peñata-Taborda, A., Brango, H., Galeano-Páez, C., Bru-Cordero, O. E., Palma-Parra, M., Díaz, S. M., Trillos, C., Briceño, L., Idrovo, Á. J., Miranda-Pacheco, J., Téllez, E., Jiménez-Vidal, L., Coneo-Pretelt, A., Álvarez, A. H., Arteaga-Arroyo, G., Ricardo-Caldera, D., ... Varona-Uribe, M. (2023). Micronuclei frequency and exposure to chemical mixtures in three Colombian mining populations. Science of the Total Environment, 901, 1-19. Article 165789. https://doi.org/10.1016/j.scitotenv.2023.165789

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title = "Micronuclei frequency and exposure to chemical mixtures in three Colombian mining populations",

abstract = "The Colombian mining industry has witnessed significant growth. Depending on the scale and mineral extracted, complex chemical mixtures are generated, impacting the health of occupationally exposed populations and communities near mining projects. Increasing evidence suggests that chromosomal instability (CIN) is an important link between the development of certain diseases and exposure to complex mixtures. To better understand the effects of exposure to complex mixtures we performed a biomonitoring study on 407 healthy individuals from four areas: three located in municipalities exploiting different-scale mining systems and a reference area with no mining activity. Large, medium, and small-scale mining systems were analyzed in Montelibano (C{\'o}rdoba), artisanal and small-scale mining (ASGM) in Nech{\'i} (Antioquia), and a closed mining system in Aranzazu (Caldas). The reference area with no mining activity was established in Monter{\'i}a (C{\'o}rdoba). ICP-MS measured multi-elemental exposure in hair, and CIN was evaluated using the cytokinesis-block micronucleus technique (MNBN). Exposure to mixtures of chemical elements was comparable in workers and residents of the mining areas but significantly higher compared to reference individuals. In Montelibano, increased MNBN frequencies were associated with combined exposure to Se, Hg, Mn, Pb, and Mg. This distinct pattern significantly differed from other areas. Specifically, in Nech{\'i}, Cr, Ni, Hg, Se, and Mg emerged as the primary contributors to elevated frequencies of MNBN. In contrast, a combination of Hg and Ni played a role in increasing MNBN in Aranzazu. Interestingly, Se consistently correlated with increased MNBN frequencies across all active mining areas. Chemical elements in Montelibano exhibit a broader range compared to other mining zones, reflecting the characteristics of the high-impact and large-scale mining in the area. This research provides valuable insights into the effects of exposure to chemical mixtures, underscoring the importance of employing this approach in the risk assessment of communities, especially those from residential areas.",

author = "Karina Pastor-Sierra and Lyda Espitia-P{\'e}rez and Pedro Espitia-P{\'e}rez and Ana Pe{\~n}ata-Taborda and Hugo Brango and Claudia Galeano-P{\'a}ez and Bru-Cordero, {Osnamir El{\'i}as} and Marien Palma-Parra and D{\'i}az, {Sonia M.} and Carlos Trillos and Leonardo Brice{\~n}o and Idrovo, {{\'A}lvaro J.} and Juan Miranda-Pacheco and Eliana T{\'e}llez and Luisa Jim{\'e}nez-Vidal and Andr{\'e}s Coneo-Pretelt and {\'A}lvarez, {Alicia Humanez} and Gean Arteaga-Arroyo and Dina Ricardo-Caldera and Shirley Salcedo-Arteaga and Alexandra Porras-Ram{\'i}rez and Marcela Varona-Uribe",

note = "Publisher Copyright: {\textcopyright} 2023 The Authors",

year = "2023",

month = nov,

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doi = "10.1016/j.scitotenv.2023.165789",

language = "English (US)",

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pages = "1--19",

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Pastor-Sierra, K, Espitia-Pérez, L, Espitia-Pérez, P, Peñata-Taborda, A, Brango, H, Galeano-Páez, C, Bru-Cordero, OE, Palma-Parra, M, Díaz, SM, Trillos, C , Briceño, L, Idrovo, ÁJ, Miranda-Pacheco, J, Téllez, E, Jiménez-Vidal, L, Coneo-Pretelt, A, Álvarez, AH, Arteaga-Arroyo, G, Ricardo-Caldera, D, Salcedo-Arteaga, S, Porras-Ramírez, A & Varona-Uribe, M 2023, 'Micronuclei frequency and exposure to chemical mixtures in three Colombian mining populations', Science of the Total Environment, vol. 901, 165789, pp. 1-19. https://doi.org/10.1016/j.scitotenv.2023.165789

TY - JOUR

T1 - Micronuclei frequency and exposure to chemical mixtures in three Colombian mining populations

AU - Pastor-Sierra, Karina

AU - Espitia-Pérez, Lyda

AU - Espitia-Pérez, Pedro

AU - Peñata-Taborda, Ana

AU - Brango, Hugo

AU - Galeano-Páez, Claudia

AU - Bru-Cordero, Osnamir Elías

AU - Palma-Parra, Marien

AU - Díaz, Sonia M.

AU - Trillos, Carlos

AU - Briceño, Leonardo

AU - Idrovo, Álvaro J.

AU - Miranda-Pacheco, Juan

AU - Téllez, Eliana

AU - Jiménez-Vidal, Luisa

AU - Coneo-Pretelt, Andrés

AU - Álvarez, Alicia Humanez

AU - Arteaga-Arroyo, Gean

AU - Ricardo-Caldera, Dina

AU - Salcedo-Arteaga, Shirley

AU - Porras-Ramírez, Alexandra

AU - Varona-Uribe, Marcela

PY - 2023/11/25

Y1 - 2023/11/25

N2 - The Colombian mining industry has witnessed significant growth. Depending on the scale and mineral extracted, complex chemical mixtures are generated, impacting the health of occupationally exposed populations and communities near mining projects. Increasing evidence suggests that chromosomal instability (CIN) is an important link between the development of certain diseases and exposure to complex mixtures. To better understand the effects of exposure to complex mixtures we performed a biomonitoring study on 407 healthy individuals from four areas: three located in municipalities exploiting different-scale mining systems and a reference area with no mining activity. Large, medium, and small-scale mining systems were analyzed in Montelibano (Córdoba), artisanal and small-scale mining (ASGM) in Nechí (Antioquia), and a closed mining system in Aranzazu (Caldas). The reference area with no mining activity was established in Montería (Córdoba). ICP-MS measured multi-elemental exposure in hair, and CIN was evaluated using the cytokinesis-block micronucleus technique (MNBN). Exposure to mixtures of chemical elements was comparable in workers and residents of the mining areas but significantly higher compared to reference individuals. In Montelibano, increased MNBN frequencies were associated with combined exposure to Se, Hg, Mn, Pb, and Mg. This distinct pattern significantly differed from other areas. Specifically, in Nechí, Cr, Ni, Hg, Se, and Mg emerged as the primary contributors to elevated frequencies of MNBN. In contrast, a combination of Hg and Ni played a role in increasing MNBN in Aranzazu. Interestingly, Se consistently correlated with increased MNBN frequencies across all active mining areas. Chemical elements in Montelibano exhibit a broader range compared to other mining zones, reflecting the characteristics of the high-impact and large-scale mining in the area. This research provides valuable insights into the effects of exposure to chemical mixtures, underscoring the importance of employing this approach in the risk assessment of communities, especially those from residential areas.

AB - The Colombian mining industry has witnessed significant growth. Depending on the scale and mineral extracted, complex chemical mixtures are generated, impacting the health of occupationally exposed populations and communities near mining projects. Increasing evidence suggests that chromosomal instability (CIN) is an important link between the development of certain diseases and exposure to complex mixtures. To better understand the effects of exposure to complex mixtures we performed a biomonitoring study on 407 healthy individuals from four areas: three located in municipalities exploiting different-scale mining systems and a reference area with no mining activity. Large, medium, and small-scale mining systems were analyzed in Montelibano (Córdoba), artisanal and small-scale mining (ASGM) in Nechí (Antioquia), and a closed mining system in Aranzazu (Caldas). The reference area with no mining activity was established in Montería (Córdoba). ICP-MS measured multi-elemental exposure in hair, and CIN was evaluated using the cytokinesis-block micronucleus technique (MNBN). Exposure to mixtures of chemical elements was comparable in workers and residents of the mining areas but significantly higher compared to reference individuals. In Montelibano, increased MNBN frequencies were associated with combined exposure to Se, Hg, Mn, Pb, and Mg. This distinct pattern significantly differed from other areas. Specifically, in Nechí, Cr, Ni, Hg, Se, and Mg emerged as the primary contributors to elevated frequencies of MNBN. In contrast, a combination of Hg and Ni played a role in increasing MNBN in Aranzazu. Interestingly, Se consistently correlated with increased MNBN frequencies across all active mining areas. Chemical elements in Montelibano exhibit a broader range compared to other mining zones, reflecting the characteristics of the high-impact and large-scale mining in the area. This research provides valuable insights into the effects of exposure to chemical mixtures, underscoring the importance of employing this approach in the risk assessment of communities, especially those from residential areas.

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U2 - 10.1016/j.scitotenv.2023.165789

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JO - Science of the Total Environment

JF - Science of the Total Environment

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Micronuclei frequency and exposure to chemical mixtures in three Colombian mining populations

Abstract

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