Micronuclei frequency and exposure to chemical mixtures in three Colombian mining populations

Karina Pastor-Sierra; Lyda Espitia-Pérez; Pedro Espitia-Pérez; Ana Peñata-Taborda; Hugo Brango; Claudia Galeano-Páez; Osnamir Elías Bru-Cordero; Marien Palma-Parra; Sonia M. Díaz; Carlos Trillos; Leonardo Briceño; Álvaro J. Idrovo; Juan Miranda-Pacheco; Eliana Téllez; Luisa Jiménez-Vidal; Andrés Coneo-Pretelt; Alicia Humanez Álvarez; Gean Arteaga-Arroyo; Dina Ricardo-Caldera; Shirley Salcedo-Arteaga; Alexandra Porras-Ramírez; Marcela Varona-Uribe

doi:10.1016/j.scitotenv.2023.165789

Micronuclei frequency and exposure to chemical mixtures in three Colombian mining populations

Título traducido de la contribución: Frecuencia de micronúcleos y exposición a mezclas químicas en tres poblaciones mineras colombianas

Karina Pastor-Sierra, Lyda Espitia-Pérez, Pedro Espitia-Pérez, Ana Peñata-Taborda, Hugo Brango, Claudia Galeano-Páez, Osnamir Elías Bru-Cordero, Marien Palma-Parra, Sonia M. Díaz, Carlos Trillos, Leonardo Briceño, Álvaro J. Idrovo, Juan Miranda-Pacheco, Eliana Téllez, Luisa Jiménez-Vidal, Andrés Coneo-Pretelt, Alicia Humanez Álvarez, Gean Arteaga-Arroyo, Dina Ricardo-Caldera, Shirley Salcedo-ArteagaAlexandra Porras-Ramírez, Marcela Varona-Uribe

Producción científica: Contribución a una revista › Artículo › revisión exhaustiva

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Resumen

La industria minera colombiana ha experimentado un crecimiento significativo. Dependiendo de la escala y del mineral extraído, se generan mezclas químicas complejas que impactan la salud de las poblaciones ocupacionalmente expuestas y de las comunidades cercanas a los proyectos mineros. Cada vez hay más pruebas que sugieren que la inestabilidad cromosómica (NIC) es un vínculo importante entre el desarrollo de determinadas enfermedades y la exposición a mezclas complejas. Para comprender mejor los efectos de la exposición a mezclas complejas, realizamos un estudio de biomonitoreo en 407 individuos sanos de cuatro áreas: tres ubicadas en municipios que explotan sistemas mineros a diferentes escalas y un área de referencia sin actividad minera. Se analizaron sistemas mineros de gran, mediana y pequeña escala en Montelíbano (Córdoba), la minería artesanal y de pequeña escala (MAPE) en Nechí (Antioquia) y un sistema minero cerrado en Aranzazu (Caldas). La zona de referencia sin actividad minera se estableció en Montería (Córdoba). ICP-MS midió la exposición a múltiples elementos en el cabello y la NIC se evaluó mediante la técnica de micronúcleos de bloqueo de citocinesis (MNBN). La exposición a mezclas de elementos químicos fue comparable en trabajadores y residentes de las zonas mineras, pero significativamente mayor en comparación con los individuos de referencia. En Montelíbano, el aumento de las frecuencias de MNBN se asoció con la exposición combinada a Se, Hg, Mn, Pb y Mg. Este patrón distintivo difería significativamente de otras áreas. Específicamente, en Nechí, Cr, Ni, Hg, Se y Mg surgieron como los principales contribuyentes a las frecuencias elevadas de MNBN. Por el contrario, una combinación de Hg y Ni jugó un papel en el aumento del MNBN en Aranzazu. Curiosamente, Se se correlacionó consistentemente con mayores frecuencias de MNBN en todas las áreas mineras activas. Los elementos químicos en Montelíbano exhiben una gama más amplia en comparación con otras zonas mineras, lo que refleja las características de la minería de alto impacto y gran escala en el área. Esta investigación proporciona información valiosa sobre los efectos de la exposición a mezclas químicas, subrayando la importancia de emplear este enfoque en la evaluación de riesgos de las comunidades, especialmente aquellas de áreas residenciales.

Título traducido de la contribución	Frecuencia de micronúcleos y exposición a mezclas químicas en tres poblaciones mineras colombianas
Idioma original	Inglés estadounidense
Número de artículo	165789
Páginas (desde-hasta)	1-19
Número de páginas	19
Publicación	Science of the Total Environment
Volumen	901
DOI	https://doi.org/10.1016/j.scitotenv.2023.165789
Estado	Publicada - nov. 25 2023

Áreas temáticas de ASJC Scopus

Ingeniería ambiental
Química ambiental
Gestión y eliminación de residuos
Contaminación

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Pastor-Sierra, K., Espitia-Pérez, L., Espitia-Pérez, P., Peñata-Taborda, A., Brango, H., Galeano-Páez, C., Bru-Cordero, O. E., Palma-Parra, M., Díaz, S. M., Trillos, C., Briceño, L., Idrovo, Á. J., Miranda-Pacheco, J., Téllez, E., Jiménez-Vidal, L., Coneo-Pretelt, A., Álvarez, A. H., Arteaga-Arroyo, G., Ricardo-Caldera, D., ... Varona-Uribe, M. (2023). Micronuclei frequency and exposure to chemical mixtures in three Colombian mining populations. Science of the Total Environment, 901, 1-19. Artículo 165789. https://doi.org/10.1016/j.scitotenv.2023.165789

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title = "Micronuclei frequency and exposure to chemical mixtures in three Colombian mining populations",

abstract = "The Colombian mining industry has witnessed significant growth. Depending on the scale and mineral extracted, complex chemical mixtures are generated, impacting the health of occupationally exposed populations and communities near mining projects. Increasing evidence suggests that chromosomal instability (CIN) is an important link between the development of certain diseases and exposure to complex mixtures. To better understand the effects of exposure to complex mixtures we performed a biomonitoring study on 407 healthy individuals from four areas: three located in municipalities exploiting different-scale mining systems and a reference area with no mining activity. Large, medium, and small-scale mining systems were analyzed in Montelibano (C{\'o}rdoba), artisanal and small-scale mining (ASGM) in Nech{\'i} (Antioquia), and a closed mining system in Aranzazu (Caldas). The reference area with no mining activity was established in Monter{\'i}a (C{\'o}rdoba). ICP-MS measured multi-elemental exposure in hair, and CIN was evaluated using the cytokinesis-block micronucleus technique (MNBN). Exposure to mixtures of chemical elements was comparable in workers and residents of the mining areas but significantly higher compared to reference individuals. In Montelibano, increased MNBN frequencies were associated with combined exposure to Se, Hg, Mn, Pb, and Mg. This distinct pattern significantly differed from other areas. Specifically, in Nech{\'i}, Cr, Ni, Hg, Se, and Mg emerged as the primary contributors to elevated frequencies of MNBN. In contrast, a combination of Hg and Ni played a role in increasing MNBN in Aranzazu. Interestingly, Se consistently correlated with increased MNBN frequencies across all active mining areas. Chemical elements in Montelibano exhibit a broader range compared to other mining zones, reflecting the characteristics of the high-impact and large-scale mining in the area. This research provides valuable insights into the effects of exposure to chemical mixtures, underscoring the importance of employing this approach in the risk assessment of communities, especially those from residential areas.",

author = "Karina Pastor-Sierra and Lyda Espitia-P{\'e}rez and Pedro Espitia-P{\'e}rez and Ana Pe{\~n}ata-Taborda and Hugo Brango and Claudia Galeano-P{\'a}ez and Bru-Cordero, {Osnamir El{\'i}as} and Marien Palma-Parra and D{\'i}az, {Sonia M.} and Carlos Trillos and Leonardo Brice{\~n}o and Idrovo, {{\'A}lvaro J.} and Juan Miranda-Pacheco and Eliana T{\'e}llez and Luisa Jim{\'e}nez-Vidal and Andr{\'e}s Coneo-Pretelt and {\'A}lvarez, {Alicia Humanez} and Gean Arteaga-Arroyo and Dina Ricardo-Caldera and Shirley Salcedo-Arteaga and Alexandra Porras-Ram{\'i}rez and Marcela Varona-Uribe",

note = "Publisher Copyright: {\textcopyright} 2023 The Authors",

year = "2023",

month = nov,

day = "25",

doi = "10.1016/j.scitotenv.2023.165789",

language = "English (US)",

volume = "901",

pages = "1--19",

journal = "Science of the Total Environment",

issn = "0048-9697",

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Pastor-Sierra, K, Espitia-Pérez, L, Espitia-Pérez, P, Peñata-Taborda, A, Brango, H, Galeano-Páez, C, Bru-Cordero, OE, Palma-Parra, M, Díaz, SM, Trillos, C , Briceño, L, Idrovo, ÁJ, Miranda-Pacheco, J, Téllez, E, Jiménez-Vidal, L, Coneo-Pretelt, A, Álvarez, AH, Arteaga-Arroyo, G, Ricardo-Caldera, D, Salcedo-Arteaga, S, Porras-Ramírez, A & Varona-Uribe, M 2023, 'Micronuclei frequency and exposure to chemical mixtures in three Colombian mining populations', Science of the Total Environment, vol. 901, 165789, pp. 1-19. https://doi.org/10.1016/j.scitotenv.2023.165789

TY - JOUR

T1 - Micronuclei frequency and exposure to chemical mixtures in three Colombian mining populations

AU - Pastor-Sierra, Karina

AU - Espitia-Pérez, Lyda

AU - Espitia-Pérez, Pedro

AU - Peñata-Taborda, Ana

AU - Brango, Hugo

AU - Galeano-Páez, Claudia

AU - Bru-Cordero, Osnamir Elías

AU - Palma-Parra, Marien

AU - Díaz, Sonia M.

AU - Trillos, Carlos

AU - Briceño, Leonardo

AU - Idrovo, Álvaro J.

AU - Miranda-Pacheco, Juan

AU - Téllez, Eliana

AU - Jiménez-Vidal, Luisa

AU - Coneo-Pretelt, Andrés

AU - Álvarez, Alicia Humanez

AU - Arteaga-Arroyo, Gean

AU - Ricardo-Caldera, Dina

AU - Salcedo-Arteaga, Shirley

AU - Porras-Ramírez, Alexandra

AU - Varona-Uribe, Marcela

PY - 2023/11/25

Y1 - 2023/11/25

N2 - The Colombian mining industry has witnessed significant growth. Depending on the scale and mineral extracted, complex chemical mixtures are generated, impacting the health of occupationally exposed populations and communities near mining projects. Increasing evidence suggests that chromosomal instability (CIN) is an important link between the development of certain diseases and exposure to complex mixtures. To better understand the effects of exposure to complex mixtures we performed a biomonitoring study on 407 healthy individuals from four areas: three located in municipalities exploiting different-scale mining systems and a reference area with no mining activity. Large, medium, and small-scale mining systems were analyzed in Montelibano (Córdoba), artisanal and small-scale mining (ASGM) in Nechí (Antioquia), and a closed mining system in Aranzazu (Caldas). The reference area with no mining activity was established in Montería (Córdoba). ICP-MS measured multi-elemental exposure in hair, and CIN was evaluated using the cytokinesis-block micronucleus technique (MNBN). Exposure to mixtures of chemical elements was comparable in workers and residents of the mining areas but significantly higher compared to reference individuals. In Montelibano, increased MNBN frequencies were associated with combined exposure to Se, Hg, Mn, Pb, and Mg. This distinct pattern significantly differed from other areas. Specifically, in Nechí, Cr, Ni, Hg, Se, and Mg emerged as the primary contributors to elevated frequencies of MNBN. In contrast, a combination of Hg and Ni played a role in increasing MNBN in Aranzazu. Interestingly, Se consistently correlated with increased MNBN frequencies across all active mining areas. Chemical elements in Montelibano exhibit a broader range compared to other mining zones, reflecting the characteristics of the high-impact and large-scale mining in the area. This research provides valuable insights into the effects of exposure to chemical mixtures, underscoring the importance of employing this approach in the risk assessment of communities, especially those from residential areas.

AB - The Colombian mining industry has witnessed significant growth. Depending on the scale and mineral extracted, complex chemical mixtures are generated, impacting the health of occupationally exposed populations and communities near mining projects. Increasing evidence suggests that chromosomal instability (CIN) is an important link between the development of certain diseases and exposure to complex mixtures. To better understand the effects of exposure to complex mixtures we performed a biomonitoring study on 407 healthy individuals from four areas: three located in municipalities exploiting different-scale mining systems and a reference area with no mining activity. Large, medium, and small-scale mining systems were analyzed in Montelibano (Córdoba), artisanal and small-scale mining (ASGM) in Nechí (Antioquia), and a closed mining system in Aranzazu (Caldas). The reference area with no mining activity was established in Montería (Córdoba). ICP-MS measured multi-elemental exposure in hair, and CIN was evaluated using the cytokinesis-block micronucleus technique (MNBN). Exposure to mixtures of chemical elements was comparable in workers and residents of the mining areas but significantly higher compared to reference individuals. In Montelibano, increased MNBN frequencies were associated with combined exposure to Se, Hg, Mn, Pb, and Mg. This distinct pattern significantly differed from other areas. Specifically, in Nechí, Cr, Ni, Hg, Se, and Mg emerged as the primary contributors to elevated frequencies of MNBN. In contrast, a combination of Hg and Ni played a role in increasing MNBN in Aranzazu. Interestingly, Se consistently correlated with increased MNBN frequencies across all active mining areas. Chemical elements in Montelibano exhibit a broader range compared to other mining zones, reflecting the characteristics of the high-impact and large-scale mining in the area. This research provides valuable insights into the effects of exposure to chemical mixtures, underscoring the importance of employing this approach in the risk assessment of communities, especially those from residential areas.

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Micronuclei frequency and exposure to chemical mixtures in three Colombian mining populations

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Áreas temáticas de ASJC Scopus

ODS de las Naciones Unidas

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