TY - JOUR
T1 - Exposure to pesticide mixtures and DNA damage among rice field workers
AU - Varona-Uribe, Marcela Eugenia
AU - Torres-Rey, Carlos H.
AU - Díaz-Criollo, Sonia
AU - Palma-Parra, Ruth Marien
AU - Narváez, Diana María
AU - Carmona, Sandra Patricia
AU - Briceño, Leonardo
AU - Idrovo, Alvaro J.
N1 - Publisher Copyright:
© 2016 Taylor & Francis.
PY - 2016/1/2
Y1 - 2016/1/2
N2 - This study describes the use of pesticides mixtures and their potential association with comet assay results in 223 rice field workers in Colombia. Thirty-one pesticides were quantified in blood, serum, and urine (15 organochlorines, 10 organophosphorus, 5 carbamates, and ethylenethiourea), and the comet assay was performed. Twenty-four (77.42%) pesticides were present in the workers. The use of the maximum-likelihood factor analysis identified 8 different mixtures. Afterwards, robust regressions were used to explore associations between the factors identified and the comet assay. Two groups of mixtures-α-benzene hexachloride (α-BHC), hexachlorobenzene (HCB), and β-BHC (β: 1.21, 95% confidence interval [CI]: 0.33-2.10) and pirimiphos-methyl, malathion, bromophos-methyl, and bromophos-ethyl (β: 11.97, 95% CI: 2.34-21.60)-were associated with a higher percentage of DNA damage and comet tail length, respectively. The findings suggest that exposure to pesticides varies greatly among rice field workers.
AB - This study describes the use of pesticides mixtures and their potential association with comet assay results in 223 rice field workers in Colombia. Thirty-one pesticides were quantified in blood, serum, and urine (15 organochlorines, 10 organophosphorus, 5 carbamates, and ethylenethiourea), and the comet assay was performed. Twenty-four (77.42%) pesticides were present in the workers. The use of the maximum-likelihood factor analysis identified 8 different mixtures. Afterwards, robust regressions were used to explore associations between the factors identified and the comet assay. Two groups of mixtures-α-benzene hexachloride (α-BHC), hexachlorobenzene (HCB), and β-BHC (β: 1.21, 95% confidence interval [CI]: 0.33-2.10) and pirimiphos-methyl, malathion, bromophos-methyl, and bromophos-ethyl (β: 11.97, 95% CI: 2.34-21.60)-were associated with a higher percentage of DNA damage and comet tail length, respectively. The findings suggest that exposure to pesticides varies greatly among rice field workers.
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U2 - 10.1080/19338244.2014.910489
DO - 10.1080/19338244.2014.910489
M3 - Article
C2 - 24972111
AN - SCOPUS:84955390529
SN - 1933-8244
VL - 71
SP - 3
EP - 9
JO - Archives of Environmental and Occupational Health
JF - Archives of Environmental and Occupational Health
IS - 1
ER -
