TY - JOUR
T1 - Exercise dose on hepatic fat and cardiovascular health in adolescents with excess of adiposity
AU - González-Ruíz, Katherine
AU - Correa-Bautista, Jorge Enrique
AU - Izquierdo, Mikel
AU - García-Hermoso, Antonio
AU - Martínez-Vizcaíno, Vicente
AU - Lobelo, Felipe
AU - González-Jiménez, Emilio
AU - Schmidt-RioValle, Jacqueline
AU - Correa-Rodríguez, María
AU - Fernández-Irigoyen, Joaquín
AU - Palomino-Echeverría, Sara
AU - Santamaría, Enrique
AU - Ramírez-Vélez, Robinson
N1 - Publisher Copyright:
© 2021 World Obesity Federation
PY - 2021
Y1 - 2021
N2 - Objective: The HEPAFIT study was aimed at examining the impact of a 6-month physical education intervention, considering various levels of exercise intensity, on hepatic fat and cardiometabolic health outcomes in adolescents with excess adiposity. Methods: Adolescents (n = 120), 11–17 years with excess adiposity by body fat >30%, were randomly assigned to one of the following 4 groups for 6 months: (1) standard physical education lessons, control (CTRL); (2) high-intensity physical education (HIPE); (3) low-to-moderate intensity physical education (LIPE) and (4) combined HIPE and LIPE (PLUS). The primary outcome was hepatic fat content measured by vibration-controlled transient elastography (controlled attenuation parameter [CAP]). Secondary outcomes were traditional cardiovascular health markers (body composition, serum lipids, aminotransferases and health-related physical fitness components). Results: Adjusted mixed effects linear models revealed a significant decrease in CAP levels in HIPE (−20.02 dB/m, p < 0.0001) (p = 0.001 vs. CTRL group) and PLUS (−16.25 dB/m, p = 0.005) groups. Body fat decreased in the HIPE (−2.88%, p < 0.001) (p = 0.001 vs. CTRL group) and LIPE (−1.26%, p = 0.022) groups. The physical fitness components were increased in the HIPE and PLUS group relative to the baseline (p < 0.05), and the HIPE group showed a reduction in the total cholesterol and low-density lipoprotein cholesterol (LDL-C) levels (p < 0.05). Conclusions: Implementation of a 6-month physical education exercise program, particularly high-intensity or combined high and low-intensity, improves hepatic fat storage and significantly reduces cardiometabolic markers in adolescents with excess of adiposity. Interventions involving supervised physical exercise may help to improve metabolism and fat deposition at the hepatic level, thus preventing the development of non-alcoholic fatty liver disease in adolescents.
AB - Objective: The HEPAFIT study was aimed at examining the impact of a 6-month physical education intervention, considering various levels of exercise intensity, on hepatic fat and cardiometabolic health outcomes in adolescents with excess adiposity. Methods: Adolescents (n = 120), 11–17 years with excess adiposity by body fat >30%, were randomly assigned to one of the following 4 groups for 6 months: (1) standard physical education lessons, control (CTRL); (2) high-intensity physical education (HIPE); (3) low-to-moderate intensity physical education (LIPE) and (4) combined HIPE and LIPE (PLUS). The primary outcome was hepatic fat content measured by vibration-controlled transient elastography (controlled attenuation parameter [CAP]). Secondary outcomes were traditional cardiovascular health markers (body composition, serum lipids, aminotransferases and health-related physical fitness components). Results: Adjusted mixed effects linear models revealed a significant decrease in CAP levels in HIPE (−20.02 dB/m, p < 0.0001) (p = 0.001 vs. CTRL group) and PLUS (−16.25 dB/m, p = 0.005) groups. Body fat decreased in the HIPE (−2.88%, p < 0.001) (p = 0.001 vs. CTRL group) and LIPE (−1.26%, p = 0.022) groups. The physical fitness components were increased in the HIPE and PLUS group relative to the baseline (p < 0.05), and the HIPE group showed a reduction in the total cholesterol and low-density lipoprotein cholesterol (LDL-C) levels (p < 0.05). Conclusions: Implementation of a 6-month physical education exercise program, particularly high-intensity or combined high and low-intensity, improves hepatic fat storage and significantly reduces cardiometabolic markers in adolescents with excess of adiposity. Interventions involving supervised physical exercise may help to improve metabolism and fat deposition at the hepatic level, thus preventing the development of non-alcoholic fatty liver disease in adolescents.
UR - http://www.scopus.com/inward/record.url?scp=85118490454&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85118490454&partnerID=8YFLogxK
U2 - 10.1111/ijpo.12869
DO - 10.1111/ijpo.12869
M3 - Article
C2 - 34734674
AN - SCOPUS:85118490454
SN - 2047-6302
JO - Pediatric obesity
JF - Pediatric obesity
ER -