Exercise dose on hepatic fat and cardiovascular health in adolescents with excess of adiposity

Katherine González-Ruíz; Jorge Enrique Correa-Bautista; Mikel Izquierdo; Antonio García-Hermoso; Vicente Martínez-Vizcaíno; Felipe Lobelo; Emilio González-Jiménez; Jacqueline Schmidt-RioValle; María Correa-Rodríguez; Joaquín Fernández-Irigoyen; Sara Palomino-Echeverría; Enrique Santamaría; Robinson Ramírez-Vélez

doi:10.1111/ijpo.12869

Exercise dose on hepatic fat and cardiovascular health in adolescents with excess of adiposity

Título traducido de la contribución: Dosis de ejercicio sobre la grasa hepática y la salud cardiovascular en adolescentes con exceso de adiposidad

Katherine González-Ruíz, Jorge Enrique Correa-Bautista, Mikel Izquierdo, Antonio García-Hermoso, Vicente Martínez-Vizcaíno, Felipe Lobelo, Emilio González-Jiménez, Jacqueline Schmidt-RioValle, María Correa-Rodríguez, Joaquín Fernández-Irigoyen, Sara Palomino-Echeverría, Enrique Santamaría, Robinson Ramírez-Vélez

Producción científica: Contribución a una revista › Artículo de Investigación › revisión exhaustiva

10 Citas (Scopus)

Resumen

Objetivo: El estudio HEPAFIT tuvo como objetivo examinar el impacto de una intervención de educación física de 6 meses, considerando varios niveles de intensidad de ejercicio, sobre la grasa hepática y los resultados de salud cardiometabólica en adolescentes con exceso de adiposidad. Métodos: Adolescentes (n = 120), de 11 a 17 años con exceso de adiposidad por grasa corporal >30%, fueron asignados aleatoriamente a uno de los siguientes 4 grupos durante 6 meses: (1) lecciones estándar de educación física, control (CTRL); (2) educación física de alta intensidad (HIPE); (3) educación física de intensidad baja a moderada (LIPE) y (4) HIPE y LIPE combinados (PLUS). El resultado primario fue el contenido de grasa hepática medido mediante elastografía transitoria controlada por vibración (parámetro de atenuación controlada [PAC]). Los resultados secundarios fueron los marcadores tradicionales de salud cardiovascular (composición corporal, lípidos séricos, aminotransferasas y componentes de la forma física relacionados con la salud). Resultados: Los modelos lineales de efectos mixtos ajustados revelaron una disminución significativa de los niveles de PAC en los grupos HIPE (-20,02 dB/m, p < 0,0001) (p = 0,001 frente al grupo CTRL) y PLUS (-16,25 dB/m, p = 0,005). La grasa corporal disminuyó en los grupos HIPE (-2,88%, p < 0,001) (p = 0,001 frente al grupo CTRL) y LIPE (-1,26%, p = 0,022). Los componentes de la forma física aumentaron en los grupos HIPE y PLUS en relación con el valor basal (p < 0,05), y el grupo HIPE mostró una reducción de los niveles de colesterol total y colesterol de lipoproteínas de baja densidad (LDL-C) (p < 0,05). Conclusiones: La implementación de un programa de ejercicio de educación física de 6 meses, particularmente de alta intensidad o combinado de alta y baja intensidad, mejora el almacenamiento de grasa hepática y reduce significativamente los marcadores cardiometabólicos en adolescentes con exceso de adiposidad. Las intervenciones que implican ejercicio físico supervisado pueden contribuir a mejorar el metabolismo y el depósito de grasa a nivel hepático, previniendo así el desarrollo de la enfermedad del hígado graso no alcohólico en adolescentes.

Título traducido de la contribución	Dosis de ejercicio sobre la grasa hepática y la salud cardiovascular en adolescentes con exceso de adiposidad
Idioma original	Inglés estadounidense
Número de artículo	e12869
Publicación	Pediatric obesity
Volumen	17
N.º	4
DOI	https://doi.org/10.1111/ijpo.12869
Estado	Publicación electrónica previa a su impresión - nov. 4 2021

Áreas temáticas de ASJC Scopus

Pediatría, perinaltología y salud infantil
Políticas sanitarias
Nutrición y dietética
Salud pública, medioambiental y laboral

ODS de las Naciones Unidas

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González-Ruíz, K., Correa-Bautista, J. E., Izquierdo, M., García-Hermoso, A., Martínez-Vizcaíno, V., Lobelo, F., González-Jiménez, E., Schmidt-RioValle, J., Correa-Rodríguez, M., Fernández-Irigoyen, J., Palomino-Echeverría, S., Santamaría, E., & Ramírez-Vélez, R. (2021). Exercise dose on hepatic fat and cardiovascular health in adolescents with excess of adiposity. Pediatric obesity, 17(4), Artículo e12869. Avanzar publicación online. https://doi.org/10.1111/ijpo.12869

@article{9ff17b5347f94700afb69e1261d54654,

title = "Exercise dose on hepatic fat and cardiovascular health in adolescents with excess of adiposity",

abstract = "Objective: The HEPAFIT study was aimed at examining the impact of a 6-month physical education intervention, considering various levels of exercise intensity, on hepatic fat and cardiometabolic health outcomes in adolescents with excess adiposity. Methods: Adolescents (n = 120), 11–17 years with excess adiposity by body fat >30%, were randomly assigned to one of the following 4 groups for 6 months: (1) standard physical education lessons, control (CTRL); (2) high-intensity physical education (HIPE); (3) low-to-moderate intensity physical education (LIPE) and (4) combined HIPE and LIPE (PLUS). The primary outcome was hepatic fat content measured by vibration-controlled transient elastography (controlled attenuation parameter [CAP]). Secondary outcomes were traditional cardiovascular health markers (body composition, serum lipids, aminotransferases and health-related physical fitness components). Results: Adjusted mixed effects linear models revealed a significant decrease in CAP levels in HIPE (−20.02 dB/m, p < 0.0001) (p = 0.001 vs. CTRL group) and PLUS (−16.25 dB/m, p = 0.005) groups. Body fat decreased in the HIPE (−2.88%, p < 0.001) (p = 0.001 vs. CTRL group) and LIPE (−1.26%, p = 0.022) groups. The physical fitness components were increased in the HIPE and PLUS group relative to the baseline (p < 0.05), and the HIPE group showed a reduction in the total cholesterol and low-density lipoprotein cholesterol (LDL-C) levels (p < 0.05). Conclusions: Implementation of a 6-month physical education exercise program, particularly high-intensity or combined high and low-intensity, improves hepatic fat storage and significantly reduces cardiometabolic markers in adolescents with excess of adiposity. Interventions involving supervised physical exercise may help to improve metabolism and fat deposition at the hepatic level, thus preventing the development of non-alcoholic fatty liver disease in adolescents.",

author = "Katherine Gonz{\'a}lez-Ru{\'i}z and Correa-Bautista, {Jorge Enrique} and Mikel Izquierdo and Antonio Garc{\'i}a-Hermoso and Vicente Mart{\'i}nez-Vizca{\'i}no and Felipe Lobelo and Emilio Gonz{\'a}lez-Jim{\'e}nez and Jacqueline Schmidt-RioValle and Mar{\'i}a Correa-Rodr{\'i}guez and Joaqu{\'i}n Fern{\'a}ndez-Irigoyen and Sara Palomino-Echeverr{\'i}a and Enrique Santamar{\'i}a and Robinson Ram{\'i}rez-V{\'e}lez",

note = "Publisher Copyright: {\textcopyright} 2021 World Obesity Federation",

year = "2021",

month = nov,

day = "4",

doi = "10.1111/ijpo.12869",

language = "English (US)",

volume = "17",

journal = "Pediatric obesity",

issn = "2047-6302",

publisher = "Wiley-Blackwell for the International Association for the Study of Obesity",

number = "4",

}

González-Ruíz, K, Correa-Bautista, JE, Izquierdo, M, García-Hermoso, A, Martínez-Vizcaíno, V, Lobelo, F, González-Jiménez, E, Schmidt-RioValle, J, Correa-Rodríguez, M, Fernández-Irigoyen, J, Palomino-Echeverría, S, Santamaría, E & Ramírez-Vélez, R 2021, 'Exercise dose on hepatic fat and cardiovascular health in adolescents with excess of adiposity', Pediatric obesity, vol. 17, n.º 4, e12869. https://doi.org/10.1111/ijpo.12869

TY - JOUR

T1 - Exercise dose on hepatic fat and cardiovascular health in adolescents with excess of adiposity

AU - González-Ruíz, Katherine

AU - Correa-Bautista, Jorge Enrique

AU - Izquierdo, Mikel

AU - García-Hermoso, Antonio

AU - Martínez-Vizcaíno, Vicente

AU - Lobelo, Felipe

AU - González-Jiménez, Emilio

AU - Schmidt-RioValle, Jacqueline

AU - Correa-Rodríguez, María

AU - Fernández-Irigoyen, Joaquín

AU - Palomino-Echeverría, Sara

AU - Santamaría, Enrique

AU - Ramírez-Vélez, Robinson

PY - 2021/11/4

Y1 - 2021/11/4

N2 - Objective: The HEPAFIT study was aimed at examining the impact of a 6-month physical education intervention, considering various levels of exercise intensity, on hepatic fat and cardiometabolic health outcomes in adolescents with excess adiposity. Methods: Adolescents (n = 120), 11–17 years with excess adiposity by body fat >30%, were randomly assigned to one of the following 4 groups for 6 months: (1) standard physical education lessons, control (CTRL); (2) high-intensity physical education (HIPE); (3) low-to-moderate intensity physical education (LIPE) and (4) combined HIPE and LIPE (PLUS). The primary outcome was hepatic fat content measured by vibration-controlled transient elastography (controlled attenuation parameter [CAP]). Secondary outcomes were traditional cardiovascular health markers (body composition, serum lipids, aminotransferases and health-related physical fitness components). Results: Adjusted mixed effects linear models revealed a significant decrease in CAP levels in HIPE (−20.02 dB/m, p < 0.0001) (p = 0.001 vs. CTRL group) and PLUS (−16.25 dB/m, p = 0.005) groups. Body fat decreased in the HIPE (−2.88%, p < 0.001) (p = 0.001 vs. CTRL group) and LIPE (−1.26%, p = 0.022) groups. The physical fitness components were increased in the HIPE and PLUS group relative to the baseline (p < 0.05), and the HIPE group showed a reduction in the total cholesterol and low-density lipoprotein cholesterol (LDL-C) levels (p < 0.05). Conclusions: Implementation of a 6-month physical education exercise program, particularly high-intensity or combined high and low-intensity, improves hepatic fat storage and significantly reduces cardiometabolic markers in adolescents with excess of adiposity. Interventions involving supervised physical exercise may help to improve metabolism and fat deposition at the hepatic level, thus preventing the development of non-alcoholic fatty liver disease in adolescents.

AB - Objective: The HEPAFIT study was aimed at examining the impact of a 6-month physical education intervention, considering various levels of exercise intensity, on hepatic fat and cardiometabolic health outcomes in adolescents with excess adiposity. Methods: Adolescents (n = 120), 11–17 years with excess adiposity by body fat >30%, were randomly assigned to one of the following 4 groups for 6 months: (1) standard physical education lessons, control (CTRL); (2) high-intensity physical education (HIPE); (3) low-to-moderate intensity physical education (LIPE) and (4) combined HIPE and LIPE (PLUS). The primary outcome was hepatic fat content measured by vibration-controlled transient elastography (controlled attenuation parameter [CAP]). Secondary outcomes were traditional cardiovascular health markers (body composition, serum lipids, aminotransferases and health-related physical fitness components). Results: Adjusted mixed effects linear models revealed a significant decrease in CAP levels in HIPE (−20.02 dB/m, p < 0.0001) (p = 0.001 vs. CTRL group) and PLUS (−16.25 dB/m, p = 0.005) groups. Body fat decreased in the HIPE (−2.88%, p < 0.001) (p = 0.001 vs. CTRL group) and LIPE (−1.26%, p = 0.022) groups. The physical fitness components were increased in the HIPE and PLUS group relative to the baseline (p < 0.05), and the HIPE group showed a reduction in the total cholesterol and low-density lipoprotein cholesterol (LDL-C) levels (p < 0.05). Conclusions: Implementation of a 6-month physical education exercise program, particularly high-intensity or combined high and low-intensity, improves hepatic fat storage and significantly reduces cardiometabolic markers in adolescents with excess of adiposity. Interventions involving supervised physical exercise may help to improve metabolism and fat deposition at the hepatic level, thus preventing the development of non-alcoholic fatty liver disease in adolescents.

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U2 - 10.1111/ijpo.12869

DO - 10.1111/ijpo.12869

M3 - Research Article

C2 - 34734674

AN - SCOPUS:85118490454

SN - 2047-6302

VL - 17

JO - Pediatric obesity

JF - Pediatric obesity

IS - 4

M1 - e12869

ER -

Exercise dose on hepatic fat and cardiovascular health in adolescents with excess of adiposity

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