Evaluation of OIDx Histoplasma urinary antigen EIA

Diego H Cáceres; Beatriz L. Gómez; Ángela M Tobón; Tom M Chiller; Mark D Lindsley

doi:10.1007/s11046-021-00602-9

Evaluation of OIDx Histoplasma urinary antigen EIA

Diego H Cáceres, Beatriz L. Gómez, Ángela M Tobón, Tom M Chiller, Mark D Lindsley

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Abstract

A sandwich enzyme immunoassay (EIA) for the detection of Histoplasma antigens (Ag) in urine, developed by Optimum Imaging Diagnostics (OIDx) was evaluated. A verification using a standardized reference panel of urine samples found sensitivity of 92%, specificity of 32% and accuracy of 51%. In this study, the OIDx Histoplasma urinary Ag EIA displayed high sensitivity, however, in non-histoplasmosis cases this EIA displayed false-positive results in 68% of specimens tested.

Original language	English (US)
Pages (from-to)	129–131
Journal	Mycopathologia
Volume	187
DOIs	https://doi.org/10.1007/s11046-021-00602-9
State	Published - Nov 20 2021

All Science Journal Classification (ASJC) codes

General Medicine

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title = "Evaluation of OIDx Histoplasma urinary antigen EIA",

abstract = "A sandwich enzyme immunoassay (EIA) for the detection of Histoplasma antigens (Ag) in urine, developed by Optimum Imaging Diagnostics (OIDx) was evaluated. A verification using a standardized reference panel of urine samples found sensitivity of 92%, specificity of 32% and accuracy of 51%. In this study, the OIDx Histoplasma urinary Ag EIA displayed high sensitivity, however, in non-histoplasmosis cases this EIA displayed false-positive results in 68% of specimens tested.",

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note = "{\textcopyright} 2021. This is a U.S. government work and not under copyright protection in the U.S.; foreign copyright protection may apply.",

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doi = "10.1007/s11046-021-00602-9",

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T1 - Evaluation of OIDx Histoplasma urinary antigen EIA

AU - Cáceres, Diego H

AU - Gómez, Beatriz L.

AU - Tobón, Ángela M

AU - Chiller, Tom M

AU - Lindsley, Mark D

PY - 2021/11/20

Y1 - 2021/11/20

N2 - A sandwich enzyme immunoassay (EIA) for the detection of Histoplasma antigens (Ag) in urine, developed by Optimum Imaging Diagnostics (OIDx) was evaluated. A verification using a standardized reference panel of urine samples found sensitivity of 92%, specificity of 32% and accuracy of 51%. In this study, the OIDx Histoplasma urinary Ag EIA displayed high sensitivity, however, in non-histoplasmosis cases this EIA displayed false-positive results in 68% of specimens tested.

AB - A sandwich enzyme immunoassay (EIA) for the detection of Histoplasma antigens (Ag) in urine, developed by Optimum Imaging Diagnostics (OIDx) was evaluated. A verification using a standardized reference panel of urine samples found sensitivity of 92%, specificity of 32% and accuracy of 51%. In this study, the OIDx Histoplasma urinary Ag EIA displayed high sensitivity, however, in non-histoplasmosis cases this EIA displayed false-positive results in 68% of specimens tested.

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DO - 10.1007/s11046-021-00602-9

M3 - Article

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SN - 0301-486X

VL - 187

SP - 129

EP - 131

JO - Mycopathologia

JF - Mycopathologia

ER -

Evaluation of OIDx Histoplasma urinary antigen EIA

Abstract

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