Epigenetic clocks in relapse after a first episode of schizophrenia

doi:10.1038/s41537-022-00268-2

Epigenetic clocks in relapse after a first episode of schizophrenia

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Abstract

The main objective of the present study was to investigate the association between several epigenetic clocks, covering different aspects of aging, with schizophrenia relapse evaluated over a 3-year follow-up period in a cohort of ninety-one first-episode schizophrenia patients. Genome-wide DNA methylation was profiled and four epigenetic clocks, including epigenetic clocks of chronological age, mortality and telomere length were calculated. Patients that relapsed during the follow-up showed epigenetic acceleration of the telomere length clock (p = 0.030). Shorter telomere length was associated with cognitive performance (working memory, r = 0.31 p = 0.015; verbal fluency, r = 0.28 p = 0.028), but no direct effect of cognitive function or symptom severity on relapse was detected. The results of the present study suggest that epigenetic age acceleration could be involved in the clinical course of schizophrenia and could be a useful marker of relapse when measured in remission stages.

Original language	English (US)
Article number	61
Journal	Schizophrenia
Volume	8
Issue number	1
DOIs	https://doi.org/10.1038/s41537-022-00268-2
State	Published - Dec 2022
Externally published	Yes

All Science Journal Classification (ASJC) codes

Clinical Psychology
Psychiatry and Mental health
Biological Psychiatry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/s41537-022-00268-2

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@article{d2f9806cc6b046ac81f78bbb169831e0,

title = "Epigenetic clocks in relapse after a first episode of schizophrenia",

abstract = "The main objective of the present study was to investigate the association between several epigenetic clocks, covering different aspects of aging, with schizophrenia relapse evaluated over a 3-year follow-up period in a cohort of ninety-one first-episode schizophrenia patients. Genome-wide DNA methylation was profiled and four epigenetic clocks, including epigenetic clocks of chronological age, mortality and telomere length were calculated. Patients that relapsed during the follow-up showed epigenetic acceleration of the telomere length clock (p = 0.030). Shorter telomere length was associated with cognitive performance (working memory, r = 0.31 p = 0.015; verbal fluency, r = 0.28 p = 0.028), but no direct effect of cognitive function or symptom severity on relapse was detected. The results of the present study suggest that epigenetic age acceleration could be involved in the clinical course of schizophrenia and could be a useful marker of relapse when measured in remission stages.",

author = "Segura, {{\`A}lex Gonz{\'a}lez} and Llucia Prohens and Gisela Mezquida and Silvia Amoretti and Miquel Bioque and Mar{\'i}a Ribeiro and Xaquin Gurriar{\'a}n-Bas and Lide Rementer{\'i}a and Daniel Berge and Roberto Rodriguez-Jimenez and Alexandra Rold{\'a}n and Edith Pomarol-Clotet and Angela Ib{\'a}{\~n}ez and Judith Usall and Garc{\'i}a-Portilla, {Maria Paz} and Cuesta, {Manuel J.} and Mara Parellada and Ana Gonz{\'a}lez-Pinto and Esther Berrocoso and Miquel Bernardo and Sergi Mas and Gonz{\'a}lez-D{\'i}az, {Jairo M.} and N{\'e}stor Arbelo and Javier Gonz{\'a}lez-Pe{\~n}as and Laura Pina-Camacho and Alba Diestre and Judit Selma and I{\~n}aki Zorrilla and Purificaci{\'o}n L{\'o}pez and Amira Trabsa and Clara Monserrat and Luis Sanchez-Pastor and Aggie Nu{\~n}ez-Doyle and Mar Fatj{\'o}-Vilas and Salvador Sarr{\'o} and Anna Butjosa and Marta Pardo and L{\'o}pez-Ilundain, {Jose M.} and {S{\'a}nchez Torres}, {Ana M.} and Jer{\'o}nimo Saiz-Ruiz and Enriqueta Ochoa-Mangado and Olga RIevero and Concepci{\'o}n De-la-C{\'a}mara and Echevarr{\'i}a, {Rafael Segarra} and Leticia Gonz{\'a}lez-Blanco",

note = "Funding Information: This study was supported by the Carlos III Healthcare Institute, the Spanish Ministry of Science, Innovation and Universities, the European Regional Development Fund (ERDF/FEDER) (PI08/0208, PI11/00325, PI14/00612); Centro de Investigaci{\'o}n Biom{\'e}dica en Red de Salud Mental (CIBERSAM); CERCA Program; Catalan Government, the Secretariat of Universities and Research of the Department of Enterprise and Knowledge (2017SGR1562 and 2017SGR1355) and Institut de Neuroci{\`e}ncies, Universitat de Barcelona. The authors thank the Language Advisory Service at the University of Barcelona for manuscript revision. The authors also thank all subjects and their families for the time and effort spent on this study as well as Ana Meseguer for sample collection assistance. Publisher Copyright: {\textcopyright} 2022, The Author(s).",

year = "2022",

month = dec,

doi = "10.1038/s41537-022-00268-2",

language = "English (US)",

volume = "8",

journal = "Schizophrenia",

issn = "2334-265X",

publisher = "Nature Publishing Group",

number = "1",

}

TY - JOUR

T1 - Epigenetic clocks in relapse after a first episode of schizophrenia

AU - Segura, Àlex González

AU - Prohens, Llucia

AU - Mezquida, Gisela

AU - Amoretti, Silvia

AU - Bioque, Miquel

AU - Ribeiro, María

AU - Gurriarán-Bas, Xaquin

AU - Rementería, Lide

AU - Berge, Daniel

AU - Rodriguez-Jimenez, Roberto

AU - Roldán, Alexandra

AU - Pomarol-Clotet, Edith

AU - Ibáñez, Angela

AU - Usall, Judith

AU - García-Portilla, Maria Paz

AU - Cuesta, Manuel J.

AU - Parellada, Mara

AU - González-Pinto, Ana

AU - Berrocoso, Esther

AU - Bernardo, Miquel

AU - Mas, Sergi

AU - González-Díaz, Jairo M.

AU - Arbelo, Néstor

AU - González-Peñas, Javier

AU - Pina-Camacho, Laura

AU - Diestre, Alba

AU - Selma, Judit

AU - Zorrilla, Iñaki

AU - López, Purificación

AU - Trabsa, Amira

AU - Monserrat, Clara

AU - Sanchez-Pastor, Luis

AU - Nuñez-Doyle, Aggie

AU - Fatjó-Vilas, Mar

AU - Sarró, Salvador

AU - Butjosa, Anna

AU - Pardo, Marta

AU - López-Ilundain, Jose M.

AU - Sánchez Torres, Ana M.

AU - Saiz-Ruiz, Jerónimo

AU - Ochoa-Mangado, Enriqueta

AU - RIevero, Olga

AU - De-la-Cámara, Concepción

AU - Echevarría, Rafael Segarra

AU - González-Blanco, Leticia

N1 - Funding Information: This study was supported by the Carlos III Healthcare Institute, the Spanish Ministry of Science, Innovation and Universities, the European Regional Development Fund (ERDF/FEDER) (PI08/0208, PI11/00325, PI14/00612); Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM); CERCA Program; Catalan Government, the Secretariat of Universities and Research of the Department of Enterprise and Knowledge (2017SGR1562 and 2017SGR1355) and Institut de Neurociències, Universitat de Barcelona. The authors thank the Language Advisory Service at the University of Barcelona for manuscript revision. The authors also thank all subjects and their families for the time and effort spent on this study as well as Ana Meseguer for sample collection assistance. Publisher Copyright: © 2022, The Author(s).

PY - 2022/12

Y1 - 2022/12

N2 - The main objective of the present study was to investigate the association between several epigenetic clocks, covering different aspects of aging, with schizophrenia relapse evaluated over a 3-year follow-up period in a cohort of ninety-one first-episode schizophrenia patients. Genome-wide DNA methylation was profiled and four epigenetic clocks, including epigenetic clocks of chronological age, mortality and telomere length were calculated. Patients that relapsed during the follow-up showed epigenetic acceleration of the telomere length clock (p = 0.030). Shorter telomere length was associated with cognitive performance (working memory, r = 0.31 p = 0.015; verbal fluency, r = 0.28 p = 0.028), but no direct effect of cognitive function or symptom severity on relapse was detected. The results of the present study suggest that epigenetic age acceleration could be involved in the clinical course of schizophrenia and could be a useful marker of relapse when measured in remission stages.

AB - The main objective of the present study was to investigate the association between several epigenetic clocks, covering different aspects of aging, with schizophrenia relapse evaluated over a 3-year follow-up period in a cohort of ninety-one first-episode schizophrenia patients. Genome-wide DNA methylation was profiled and four epigenetic clocks, including epigenetic clocks of chronological age, mortality and telomere length were calculated. Patients that relapsed during the follow-up showed epigenetic acceleration of the telomere length clock (p = 0.030). Shorter telomere length was associated with cognitive performance (working memory, r = 0.31 p = 0.015; verbal fluency, r = 0.28 p = 0.028), but no direct effect of cognitive function or symptom severity on relapse was detected. The results of the present study suggest that epigenetic age acceleration could be involved in the clinical course of schizophrenia and could be a useful marker of relapse when measured in remission stages.

UR - http://www.scopus.com/inward/record.url?scp=85134561397&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85134561397&partnerID=8YFLogxK

U2 - 10.1038/s41537-022-00268-2

DO - 10.1038/s41537-022-00268-2

M3 - Article

C2 - 35869075

AN - SCOPUS:85134561397

SN - 2334-265X

VL - 8

JO - Schizophrenia

JF - Schizophrenia

IS - 1

M1 - 61

ER -

Epigenetic clocks in relapse after a first episode of schizophrenia

Abstract

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