TY - JOUR
T1 - Epigenetic clocks in relapse after a first episode of schizophrenia
AU - Segura, Àlex González
AU - Prohens, Llucia
AU - Mezquida, Gisela
AU - Amoretti, Silvia
AU - Bioque, Miquel
AU - Ribeiro, María
AU - Gurriarán-Bas, Xaquin
AU - Rementería, Lide
AU - Berge, Daniel
AU - Rodriguez-Jimenez, Roberto
AU - Roldán, Alexandra
AU - Pomarol-Clotet, Edith
AU - Ibáñez, Angela
AU - Usall, Judith
AU - García-Portilla, Maria Paz
AU - Cuesta, Manuel J.
AU - Parellada, Mara
AU - González-Pinto, Ana
AU - Berrocoso, Esther
AU - Bernardo, Miquel
AU - Mas, Sergi
AU - González-Díaz, Jairo M.
AU - Arbelo, Néstor
AU - González-Peñas, Javier
AU - Pina-Camacho, Laura
AU - Diestre, Alba
AU - Selma, Judit
AU - Zorrilla, Iñaki
AU - López, Purificación
AU - Trabsa, Amira
AU - Monserrat, Clara
AU - Sanchez-Pastor, Luis
AU - Nuñez-Doyle, Aggie
AU - Fatjó-Vilas, Mar
AU - Sarró, Salvador
AU - Butjosa, Anna
AU - Pardo, Marta
AU - López-Ilundain, Jose M.
AU - Sánchez Torres, Ana M.
AU - Saiz-Ruiz, Jerónimo
AU - Ochoa-Mangado, Enriqueta
AU - RIevero, Olga
AU - De-la-Cámara, Concepción
AU - Echevarría, Rafael Segarra
AU - González-Blanco, Leticia
N1 - Funding Information:
This study was supported by the Carlos III Healthcare Institute, the Spanish Ministry of Science, Innovation and Universities, the European Regional Development Fund (ERDF/FEDER) (PI08/0208, PI11/00325, PI14/00612); Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM); CERCA Program; Catalan Government, the Secretariat of Universities and Research of the Department of Enterprise and Knowledge (2017SGR1562 and 2017SGR1355) and Institut de Neurociències, Universitat de Barcelona. The authors thank the Language Advisory Service at the University of Barcelona for manuscript revision. The authors also thank all subjects and their families for the time and effort spent on this study as well as Ana Meseguer for sample collection assistance.
Publisher Copyright:
© 2022, The Author(s).
PY - 2022/12
Y1 - 2022/12
N2 - The main objective of the present study was to investigate the association between several epigenetic clocks, covering different aspects of aging, with schizophrenia relapse evaluated over a 3-year follow-up period in a cohort of ninety-one first-episode schizophrenia patients. Genome-wide DNA methylation was profiled and four epigenetic clocks, including epigenetic clocks of chronological age, mortality and telomere length were calculated. Patients that relapsed during the follow-up showed epigenetic acceleration of the telomere length clock (p = 0.030). Shorter telomere length was associated with cognitive performance (working memory, r = 0.31 p = 0.015; verbal fluency, r = 0.28 p = 0.028), but no direct effect of cognitive function or symptom severity on relapse was detected. The results of the present study suggest that epigenetic age acceleration could be involved in the clinical course of schizophrenia and could be a useful marker of relapse when measured in remission stages.
AB - The main objective of the present study was to investigate the association between several epigenetic clocks, covering different aspects of aging, with schizophrenia relapse evaluated over a 3-year follow-up period in a cohort of ninety-one first-episode schizophrenia patients. Genome-wide DNA methylation was profiled and four epigenetic clocks, including epigenetic clocks of chronological age, mortality and telomere length were calculated. Patients that relapsed during the follow-up showed epigenetic acceleration of the telomere length clock (p = 0.030). Shorter telomere length was associated with cognitive performance (working memory, r = 0.31 p = 0.015; verbal fluency, r = 0.28 p = 0.028), but no direct effect of cognitive function or symptom severity on relapse was detected. The results of the present study suggest that epigenetic age acceleration could be involved in the clinical course of schizophrenia and could be a useful marker of relapse when measured in remission stages.
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U2 - 10.1038/s41537-022-00268-2
DO - 10.1038/s41537-022-00268-2
M3 - Article
C2 - 35869075
AN - SCOPUS:85134561397
SN - 2334-265X
VL - 8
JO - Schizophrenia
JF - Schizophrenia
IS - 1
M1 - 61
ER -
