Ocular cytokinome is linked to clinical characteristics in ocular toxoplasmosis

Alejandra De-la-Torre, Alexander W. Pfaff, Michael E. Grigg, Odile Villard, Ermanno Candolfi, Jorge E. Gomez-Marin

Research output: Contribution to journalArticlepeer-review

34 Scopus citations

Abstract

Purpose: To determine the cytokine levels in aqueous humor (AH) of Colombian patients with active ocular toxoplasmosis (OT), and to correlate them with their clinical characteristics. Methods: 27 Cytokines/chemokines were assayed in 15 AH samples (nine patients with diagnosis of OT biologically-confirmed and six controls that underwent cataract surgery). Correlations were assessed between cytokine/chemokine levels, type of inflammatory response (Th1, Th2, Th17, Treg), and clinical characteristics. Results: Th2 predominant response was related to more severe clinical features. The presence of VEGF and IL-5 was related to higher number of recurrences. Growth factors (VEGF, FGF, PDGF-β), were related to higher number of lesions. Patients infected by type-I/III strains had a particular intraocular cytokine-pattern. Conclusions: Th2 response was related to more severe clinical characteristics in patients infected by Type I/III strains. IL-5 and VEGF were associated with recurrences. We correlate for the first time, specific cytokine-patterns with clinical characteristics and with the infecting Toxoplasma strain. © 2014 Elsevier Ltd.
Translated title of the contribution El citocinoma ocular está relacionado con las características clínicas de la toxoplasmosis ocular
Original languageEnglish (US)
Pages (from-to)23-31
Number of pages9
JournalCytokine
DOIs
StatePublished - Jan 1 2014

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