Ocular cytokinome is linked to clinical characteristics in ocular toxoplasmosis

Alejandra De-la-Torre, Alexander W. Pfaff, Michael E. Grigg, Odile Villard, Ermanno Candolfi, Jorge E. Gomez-Marin

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Abstract

Purpose: To determine the cytokine levels in aqueous humor (AH) of Colombian patients with active ocular toxoplasmosis (OT), and to correlate them with their clinical characteristics. Methods: 27 Cytokines/chemokines were assayed in 15 AH samples (nine patients with diagnosis of OT biologically-confirmed and six controls that underwent cataract surgery). Correlations were assessed between cytokine/chemokine levels, type of inflammatory response (Th1, Th2, Th17, Treg), and clinical characteristics. Results: Th2 predominant response was related to more severe clinical features. The presence of VEGF and IL-5 was related to higher number of recurrences. Growth factors (VEGF, FGF, PDGF-β), were related to higher number of lesions. Patients infected by type-I/III strains had a particular intraocular cytokine-pattern. Conclusions: Th2 response was related to more severe clinical characteristics in patients infected by Type I/III strains. IL-5 and VEGF were associated with recurrences. We correlate for the first time, specific cytokine-patterns with clinical characteristics and with the infecting Toxoplasma strain. © 2014 Elsevier Ltd.
Original languageEnglish (US)
Pages (from-to)23-31
Number of pages9
JournalCytokine
DOIs
StatePublished - Jan 1 2014

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Ocular Toxoplasmosis
Cytokines
Vascular Endothelial Growth Factor A
Aqueous Humor
Interleukin-5
Chemokines
Recurrence
Toxoplasma
Cataract
Surgery
Intercellular Signaling Peptides and Proteins

Cite this

De-la-Torre, A., Pfaff, A. W., Grigg, M. E., Villard, O., Candolfi, E., & Gomez-Marin, J. E. (2014). Ocular cytokinome is linked to clinical characteristics in ocular toxoplasmosis. Cytokine, 23-31. https://doi.org/10.1016/j.cyto.2014.03.005
De-la-Torre, Alejandra ; Pfaff, Alexander W. ; Grigg, Michael E. ; Villard, Odile ; Candolfi, Ermanno ; Gomez-Marin, Jorge E. / Ocular cytokinome is linked to clinical characteristics in ocular toxoplasmosis. In: Cytokine. 2014 ; pp. 23-31.
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abstract = "Purpose: To determine the cytokine levels in aqueous humor (AH) of Colombian patients with active ocular toxoplasmosis (OT), and to correlate them with their clinical characteristics. Methods: 27 Cytokines/chemokines were assayed in 15 AH samples (nine patients with diagnosis of OT biologically-confirmed and six controls that underwent cataract surgery). Correlations were assessed between cytokine/chemokine levels, type of inflammatory response (Th1, Th2, Th17, Treg), and clinical characteristics. Results: Th2 predominant response was related to more severe clinical features. The presence of VEGF and IL-5 was related to higher number of recurrences. Growth factors (VEGF, FGF, PDGF-β), were related to higher number of lesions. Patients infected by type-I/III strains had a particular intraocular cytokine-pattern. Conclusions: Th2 response was related to more severe clinical characteristics in patients infected by Type I/III strains. IL-5 and VEGF were associated with recurrences. We correlate for the first time, specific cytokine-patterns with clinical characteristics and with the infecting Toxoplasma strain. {\circledC} 2014 Elsevier Ltd.",
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Ocular cytokinome is linked to clinical characteristics in ocular toxoplasmosis. / De-la-Torre, Alejandra; Pfaff, Alexander W.; Grigg, Michael E.; Villard, Odile; Candolfi, Ermanno; Gomez-Marin, Jorge E.

In: Cytokine, 01.01.2014, p. 23-31.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Ocular cytokinome is linked to clinical characteristics in ocular toxoplasmosis

AU - De-la-Torre, Alejandra

AU - Pfaff, Alexander W.

AU - Grigg, Michael E.

AU - Villard, Odile

AU - Candolfi, Ermanno

AU - Gomez-Marin, Jorge E.

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Purpose: To determine the cytokine levels in aqueous humor (AH) of Colombian patients with active ocular toxoplasmosis (OT), and to correlate them with their clinical characteristics. Methods: 27 Cytokines/chemokines were assayed in 15 AH samples (nine patients with diagnosis of OT biologically-confirmed and six controls that underwent cataract surgery). Correlations were assessed between cytokine/chemokine levels, type of inflammatory response (Th1, Th2, Th17, Treg), and clinical characteristics. Results: Th2 predominant response was related to more severe clinical features. The presence of VEGF and IL-5 was related to higher number of recurrences. Growth factors (VEGF, FGF, PDGF-β), were related to higher number of lesions. Patients infected by type-I/III strains had a particular intraocular cytokine-pattern. Conclusions: Th2 response was related to more severe clinical characteristics in patients infected by Type I/III strains. IL-5 and VEGF were associated with recurrences. We correlate for the first time, specific cytokine-patterns with clinical characteristics and with the infecting Toxoplasma strain. © 2014 Elsevier Ltd.

AB - Purpose: To determine the cytokine levels in aqueous humor (AH) of Colombian patients with active ocular toxoplasmosis (OT), and to correlate them with their clinical characteristics. Methods: 27 Cytokines/chemokines were assayed in 15 AH samples (nine patients with diagnosis of OT biologically-confirmed and six controls that underwent cataract surgery). Correlations were assessed between cytokine/chemokine levels, type of inflammatory response (Th1, Th2, Th17, Treg), and clinical characteristics. Results: Th2 predominant response was related to more severe clinical features. The presence of VEGF and IL-5 was related to higher number of recurrences. Growth factors (VEGF, FGF, PDGF-β), were related to higher number of lesions. Patients infected by type-I/III strains had a particular intraocular cytokine-pattern. Conclusions: Th2 response was related to more severe clinical characteristics in patients infected by Type I/III strains. IL-5 and VEGF were associated with recurrences. We correlate for the first time, specific cytokine-patterns with clinical characteristics and with the infecting Toxoplasma strain. © 2014 Elsevier Ltd.

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