Ocular cytokinome is linked to clinical characteristics in ocular toxoplasmosis

Alejandra De-la-Torre; Alexander W. Pfaff; Michael E. Grigg; Odile Villard; Ermanno Candolfi; Jorge E. Gomez-Marin

doi:10.1016/j.cyto.2014.03.005

Ocular cytokinome is linked to clinical characteristics in ocular toxoplasmosis

Alejandra De-la-Torre, Alexander W. Pfaff, Michael E. Grigg, Odile Villard, Ermanno Candolfi, Jorge E. Gomez-Marin

Public Health Research Group

Research output: Contribution to journal › Research Article › peer-review

49 Scopus citations

Abstract

Purpose: To determine the cytokine levels in aqueous humor (AH) of Colombian patients with active ocular toxoplasmosis (OT), and to correlate them with their clinical characteristics. Methods: 27 Cytokines/chemokines were assayed in 15 AH samples (nine patients with diagnosis of OT biologically-confirmed and six controls that underwent cataract surgery). Correlations were assessed between cytokine/chemokine levels, type of inflammatory response (Th1, Th2, Th17, Treg), and clinical characteristics. Results: Th2 predominant response was related to more severe clinical features. The presence of VEGF and IL-5 was related to higher number of recurrences. Growth factors (VEGF, FGF, PDGF-β), were related to higher number of lesions. Patients infected by type-I/III strains had a particular intraocular cytokine-pattern. Conclusions: Th2 response was related to more severe clinical characteristics in patients infected by Type I/III strains. IL-5 and VEGF were associated with recurrences. We correlate for the first time, specific cytokine-patterns with clinical characteristics and with the infecting Toxoplasma strain. © 2014 Elsevier Ltd.

Translated title of the contribution	El citocinoma ocular está relacionado con las características clínicas de la toxoplasmosis ocular
Original language	English (US)
Pages (from-to)	23-31
Number of pages	9
Journal	Cytokine
DOIs	https://doi.org/10.1016/j.cyto.2014.03.005
State	Published - Jan 1 2014

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title = "Ocular cytokinome is linked to clinical characteristics in ocular toxoplasmosis",

abstract = "Purpose: To determine the cytokine levels in aqueous humor (AH) of Colombian patients with active ocular toxoplasmosis (OT), and to correlate them with their clinical characteristics. Methods: 27 Cytokines/chemokines were assayed in 15 AH samples (nine patients with diagnosis of OT biologically-confirmed and six controls that underwent cataract surgery). Correlations were assessed between cytokine/chemokine levels, type of inflammatory response (Th1, Th2, Th17, Treg), and clinical characteristics. Results: Th2 predominant response was related to more severe clinical features. The presence of VEGF and IL-5 was related to higher number of recurrences. Growth factors (VEGF, FGF, PDGF-β), were related to higher number of lesions. Patients infected by type-I/III strains had a particular intraocular cytokine-pattern. Conclusions: Th2 response was related to more severe clinical characteristics in patients infected by Type I/III strains. IL-5 and VEGF were associated with recurrences. We correlate for the first time, specific cytokine-patterns with clinical characteristics and with the infecting Toxoplasma strain. {\textcopyright} 2014 Elsevier Ltd.",

author = "Alejandra De-la-Torre and Pfaff, {Alexander W.} and Grigg, {Michael E.} and Odile Villard and Ermanno Candolfi and Gomez-Marin, {Jorge E.}",

year = "2014",

month = jan,

day = "1",

doi = "10.1016/j.cyto.2014.03.005",

language = "English (US)",

pages = "23--31",

journal = "Cytokine",

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T1 - Ocular cytokinome is linked to clinical characteristics in ocular toxoplasmosis

AU - De-la-Torre, Alejandra

AU - Pfaff, Alexander W.

AU - Grigg, Michael E.

AU - Villard, Odile

AU - Candolfi, Ermanno

AU - Gomez-Marin, Jorge E.

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Purpose: To determine the cytokine levels in aqueous humor (AH) of Colombian patients with active ocular toxoplasmosis (OT), and to correlate them with their clinical characteristics. Methods: 27 Cytokines/chemokines were assayed in 15 AH samples (nine patients with diagnosis of OT biologically-confirmed and six controls that underwent cataract surgery). Correlations were assessed between cytokine/chemokine levels, type of inflammatory response (Th1, Th2, Th17, Treg), and clinical characteristics. Results: Th2 predominant response was related to more severe clinical features. The presence of VEGF and IL-5 was related to higher number of recurrences. Growth factors (VEGF, FGF, PDGF-β), were related to higher number of lesions. Patients infected by type-I/III strains had a particular intraocular cytokine-pattern. Conclusions: Th2 response was related to more severe clinical characteristics in patients infected by Type I/III strains. IL-5 and VEGF were associated with recurrences. We correlate for the first time, specific cytokine-patterns with clinical characteristics and with the infecting Toxoplasma strain. © 2014 Elsevier Ltd.

AB - Purpose: To determine the cytokine levels in aqueous humor (AH) of Colombian patients with active ocular toxoplasmosis (OT), and to correlate them with their clinical characteristics. Methods: 27 Cytokines/chemokines were assayed in 15 AH samples (nine patients with diagnosis of OT biologically-confirmed and six controls that underwent cataract surgery). Correlations were assessed between cytokine/chemokine levels, type of inflammatory response (Th1, Th2, Th17, Treg), and clinical characteristics. Results: Th2 predominant response was related to more severe clinical features. The presence of VEGF and IL-5 was related to higher number of recurrences. Growth factors (VEGF, FGF, PDGF-β), were related to higher number of lesions. Patients infected by type-I/III strains had a particular intraocular cytokine-pattern. Conclusions: Th2 response was related to more severe clinical characteristics in patients infected by Type I/III strains. IL-5 and VEGF were associated with recurrences. We correlate for the first time, specific cytokine-patterns with clinical characteristics and with the infecting Toxoplasma strain. © 2014 Elsevier Ltd.

U2 - 10.1016/j.cyto.2014.03.005

DO - 10.1016/j.cyto.2014.03.005

M3 - Research Article

C2 - 24787053

SN - 1043-4666

SP - 23

EP - 31

JO - Cytokine

JF - Cytokine

ER -

Ocular cytokinome is linked to clinical characteristics in ocular toxoplasmosis

Abstract

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