TY - JOUR
T1 - Compositional heterogeneity within and among isochores in mammalian genomes
T2 - II. Some general comments
AU - Clay, Oliver
AU - Bernardi, Giorgio
N1 - Copyright:
Copyright 2007 Elsevier B.V., All rights reserved.
PY - 2001/10/3
Y1 - 2001/10/3
N2 - The presence of long-range correlations and/or mosaicism in DNA sequences results in GC fluctuations, even within individual isochores that are much larger than expected correlation-free 'random' sequences. Neglecting the presence of such fluctuations can lead to incorrect conclusions regarding relative homogeneity or isochore borders. In this commentary, we address these and other methodological issues raised by the variations in GC level within human isochores. We also discuss some recent misconceptions.
AB - The presence of long-range correlations and/or mosaicism in DNA sequences results in GC fluctuations, even within individual isochores that are much larger than expected correlation-free 'random' sequences. Neglecting the presence of such fluctuations can lead to incorrect conclusions regarding relative homogeneity or isochore borders. In this commentary, we address these and other methodological issues raised by the variations in GC level within human isochores. We also discuss some recent misconceptions.
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U2 - 10.1016/S0378-1119(01)00668-0
DO - 10.1016/S0378-1119(01)00668-0
M3 - Article
C2 - 11591468
AN - SCOPUS:0035802383
SN - 0378-1119
VL - 276
SP - 25
EP - 31
JO - Gene
JF - Gene
IS - 1-2
ER -