Compositional heterogeneity within and among isochores in mammalian genomes: II. Some general comments

Oliver Clay, Giorgio Bernardi

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

The presence of long-range correlations and/or mosaicism in DNA sequences results in GC fluctuations, even within individual isochores that are much larger than expected correlation-free 'random' sequences. Neglecting the presence of such fluctuations can lead to incorrect conclusions regarding relative homogeneity or isochore borders. In this commentary, we address these and other methodological issues raised by the variations in GC level within human isochores. We also discuss some recent misconceptions.

Original languageEnglish (US)
Pages (from-to)25-31
Number of pages7
JournalGene
Volume276
Issue number1-2
DOIs
StatePublished - Oct 3 2001
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Genetics

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