Compositional heterogeneity within and among isochores in mammalian genomes: II. Some general comments

Oliver Clay, Giorgio Bernardi

Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva

16 Citas (Scopus)

Resumen

The presence of long-range correlations and/or mosaicism in DNA sequences results in GC fluctuations, even within individual isochores that are much larger than expected correlation-free 'random' sequences. Neglecting the presence of such fluctuations can lead to incorrect conclusions regarding relative homogeneity or isochore borders. In this commentary, we address these and other methodological issues raised by the variations in GC level within human isochores. We also discuss some recent misconceptions.

Idioma originalInglés estadounidense
Páginas (desde-hasta)25-31
Número de páginas7
PublicaciónGene
Volumen276
N.º1-2
DOI
EstadoPublicada - oct 3 2001
Publicado de forma externa

All Science Journal Classification (ASJC) codes

  • Genética

Huella Profundice en los temas de investigación de 'Compositional heterogeneity within and among isochores in mammalian genomes: II. Some general comments'. En conjunto forman una huella única.

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