Nodular Necrotizing-Scleritis Associated with Epstein-Barr Virus Infection: A Case Report

Project: Research Project

Project Details


Purpose: To report a case of necrotizing scleritis associated with Epstein-Barr virus (EBV) infection. Case report: A 68-year-old woman with a history of scleral ulcer, perforation, and scleral graft, with initial negative studies for infectious processes and autoimmune systemic-diseases consulted our service for a second opinion after 2 years of treatment without improvement. She presented severe conjunctival and scleral hyperemia, vascular tortuosity in 360°, areas of scleral thinning and an elevated lesion of nodular appearance. EBV serologic antibody IgG titers were strongly positive and IgM titers were borderline. A scleral biopsy showed granulation tissue with severe inflammation without the presence of tumor cells; PCR was positive for EBV. The patient was treated with antiviral therapy with resolution of the scleritis. Conclusions: EBV although rare, should be considered as a differential diagnosis in patients with necrotizing scleritis with no improvement to conventional therapy.

Commitments / Obligations

Al ser un reporte de caso no requiere aprobación del comité de ética. Los autores certifican que obtuvieron el consentimiento y asentimiento informado del paciente. En estos, el paciente ha dado el consentimiento para que sus imágenes y su información clínica sean reportadas en el artículo. El paciente entiende que ni su nombre, ni sus iniciales, serán publicadas y se hará un esfuerzo por mantener su identidad en privado, sin embargo, la anonimidad no puede ser garantizada.
Effective start/end date1/1/199/30/19

UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This project contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

Main Funding Source

  • Installed Capacity (Academic Unit)


  • Bogotá D.C.


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