Study of the modulating effect of physical exercise on the intestinal microbiota and its repercussion on hepatic and adipose metabolism in sedentary adults with overweight: Controlled clinical trial

In the last decades, several epidemiological and observational studies have found a relationship between metabolic alterations and sedentary lifestyle with the development of cardio-cerebro-metabolic diseases (ECCM), from early stages of life. In the same way, several experimental studies have reported that interventions with exercise / physical activity could induce physiological adaptations that regulate these factors / conditions and contribute beneficially to general health. In this context, we intend to develop a parallel, simple masked clinical trial with balanced blocks randomization in 20 overweight adults, between 20 and 30 years old, sedentary, without medical history that discourage their participation in physical activities, and without dietary treatment or habits. unusual dietary In the short term, this project offers the opportunity to obtain detailed measurements on the health of body composition, metabolic health, and intestinal microbial diversity in overweight adults; and will provide information about the effects of physical exercise on them. The incorporation into the study of international and national researchers, provides a framework conducive to the formation of bilateral research networks aimed at strengthening the training of doctoral and post-doctoral students in Biomedical / Biological Sciences, Master of Physical Activity and Health, Undergraduate in Physiotherapy, Medicine and Physical Education. In the medium term, this project will advance in the understanding of the mechanisms induced by physical exercise, which includes the measurement of nutritional parameters, clinical and biochemical biomarkers of hepatic / cardiometabolic health, as well as the application of differential proteomics technologies by means of Arrays of cytokines and intestinal microbiome, making this study a novel and pioneer in sensitive areas of primary health care in Colombia and Latin America. In the long term, these results allow the validation of non-pharmacological strategies that promote actions aimed at mitigating the risk of occurrence and reduction of morbidity associated with ECCM.

Microbiota, exercise, prevention, hepatic function