The role of tryptophan in Chagas disease and other trypanosomatid infections

Lissa Briceida Cruz Saavedra, Alberto E Paniz-Mondolfi, Juan David Ramirez Gonzalez, Gustavo Benaim, Emilia Mia Sordillo

Producción científica: Capítulo en Libro/InformeCapítuloInvestigación

Resumen

The aromatic amino acid tryptophan plays a critical role in the pathogenesis of infection caused by trypanosomatid parasites, including Trypanosoma cruzi (Chagas disease), T. brucei rhodensiense and T. brucei gambiense (African sleeping sickness), and the various Leishmania species. During the parasite life cycle, tryptophan influences metabolism, changes in morphology, and movement between the invertebrate vector and the vertebrate host. In the vertebrate host, tryptophan and its metabolites influence the host inflammatory response and the transition to chronic infection. In this chapter, we review current knowledge regarding the tryptophan and kynurenine pathways in trypanosomatid parasitosis, present genomic evidence supporting their importance in trypanosomatid infections, and discuss applicability in development and assessment of new treatment modalities.
Idioma originalInglés
Título de la publicación alojadaBiophotonics, Tryptophan and Disease
EditorialAcademic Press Inc.
Capítulo5
Páginas55-66
Número de páginas11
Volumen1
Edición1
ISBN (versión impresa)9780128227909
DOI
EstadoPublicada - dic. 2021

Áreas temáticas de ASJC Scopus

  • Enfermedades infecciosas
  • Neuropsicología y psicología fisiológica

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