The role of tryptophan in Chagas disease and other trypanosomatid infections

Juan David Ramirez Gonzalez

doi:10.1016/B978-0-12-822790-9.00012-7

The role of tryptophan in Chagas disease and other trypanosomatid infections

Research output: Chapter in Book/Report › Chapter

Abstract

The aromatic amino acid tryptophan plays a critical role in the pathogenesis of infection caused by trypanosomatid parasites, including Trypanosoma cruzi (Chagas disease), T. brucei rhodensiense and T. brucei gambiense (African sleeping sickness), and the various Leishmania species. During the parasite life cycle, tryptophan influences metabolism, changes in morphology, and movement between the invertebrate vector and the vertebrate host. In the vertebrate host, tryptophan and its metabolites influence the host inflammatory response and the transition to chronic infection. In this chapter, we review current knowledge regarding the tryptophan and kynurenine pathways in trypanosomatid parasitosis, present genomic evidence supporting their importance in trypanosomatid infections, and discuss applicability in development and assessment of new treatment modalities.

Original language	English
Title of host publication	Biophotonics, Tryptophan and Disease
Publisher	Academic Press Inc.
Chapter	5
Pages	55-66
Number of pages	11
Volume	1
Edition	1
ISBN (Electronic)	978-0-12-822790-9
DOIs	https://doi.org/10.1016/B978-0-12-822790-9.00012-7
State	Published - Dec 2021

All Science Journal Classification (ASJC) codes

Infectious Diseases
Neuropsychology and Physiological Psychology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/B978-0-12-822790-9.00012-7

Cite this

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title = "The role of tryptophan in Chagas disease and other trypanosomatid infections",

abstract = "The aromatic amino acid tryptophan plays a critical role in the pathogenesis of infection caused by trypanosomatid parasites, including Trypanosoma cruzi (Chagas disease), T. brucei rhodensiense and T. brucei gambiense (African sleeping sickness), and the various Leishmania species. During the parasite life cycle, tryptophan influences metabolism, changes in morphology, and movement between the invertebrate vector and the vertebrate host. In the vertebrate host, tryptophan and its metabolites influence the host inflammatory response and the transition to chronic infection. In this chapter, we review current knowledge regarding the tryptophan and kynurenine pathways in trypanosomatid parasitosis, present genomic evidence supporting their importance in trypanosomatid infections, and discuss applicability in development and assessment of new treatment modalities.",

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AB - The aromatic amino acid tryptophan plays a critical role in the pathogenesis of infection caused by trypanosomatid parasites, including Trypanosoma cruzi (Chagas disease), T. brucei rhodensiense and T. brucei gambiense (African sleeping sickness), and the various Leishmania species. During the parasite life cycle, tryptophan influences metabolism, changes in morphology, and movement between the invertebrate vector and the vertebrate host. In the vertebrate host, tryptophan and its metabolites influence the host inflammatory response and the transition to chronic infection. In this chapter, we review current knowledge regarding the tryptophan and kynurenine pathways in trypanosomatid parasitosis, present genomic evidence supporting their importance in trypanosomatid infections, and discuss applicability in development and assessment of new treatment modalities.

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BT - Biophotonics, Tryptophan and Disease

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