Resumen
Rheumatoid pericarditis (RP) is a well known extraarticular manifestation of rheumatoid arthritis (RA). It is not frequently diagnosed despite its high reported prevalence in post-mortem studies. There have been no immunohistological studies of its presence in pericardial membranes. Here we report a complete immunohistological study of two RA patients with RP complications, using a panel of monoclonal antibodies (mAbs) for the recognition of B, T, and NK cells. Both cases showed strong and almost exclusive pericardial membrane infiltration of CD8+ T-cells which was correlated with a higher than expected similar increase in the subset of peripheral blood lymphocytes (PBL). These findings suggest an important role for CD8+ T-cells in chronic RA, especially in this extraarticular manifestation of the disease.
Idioma original | Inglés estadounidense |
---|---|
Páginas (desde-hasta) | 313-316 |
Número de páginas | 4 |
Publicación | Clinical and Experimental Rheumatology |
Volumen | 12 |
N.º | 3 |
Estado | Publicada - 1994 |
Publicado de forma externa | Sí |
Áreas temáticas de ASJC Scopus
- Reumatología
- Inmulogía y alergología
- Inmunología