Rheumatoid pericarditis: New immunopathological aspects

A. Travaglio-Encinoza, J. M. Anaya, A. D. D'Angeac, T. Reme, J. Sany

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7 Scopus citations

Abstract

Rheumatoid pericarditis (RP) is a well known extraarticular manifestation of rheumatoid arthritis (RA). It is not frequently diagnosed despite its high reported prevalence in post-mortem studies. There have been no immunohistological studies of its presence in pericardial membranes. Here we report a complete immunohistological study of two RA patients with RP complications, using a panel of monoclonal antibodies (mAbs) for the recognition of B, T, and NK cells. Both cases showed strong and almost exclusive pericardial membrane infiltration of CD8+ T-cells which was correlated with a higher than expected similar increase in the subset of peripheral blood lymphocytes (PBL). These findings suggest an important role for CD8+ T-cells in chronic RA, especially in this extraarticular manifestation of the disease.

Original languageEnglish (US)
Pages (from-to)313-316
Number of pages4
JournalClinical and Experimental Rheumatology
Volume12
Issue number3
StatePublished - 1994
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Rheumatology
  • Immunology and Allergy
  • Immunology

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