Plasmodium falciparum SERA protein peptide analogues having short helical regions induce protection against malaria

Adriana Janneth Bermudez Quintero; Marcia Cubillos; Martha Patricia Alba; Mary Trujillo; Manuel Elkin Patarroyo

doi:10.1016/S0300-9084(03)00136-6

Plasmodium falciparum SERA protein peptide analogues having short helical regions induce protection against malaria

Adriana Janneth Bermudez Quintero, Marcia Cubillos, Martha Patricia Alba, Mary Trujillo, Manuel Elkin Patarroyo

Escuela de Medicina y Ciencias de la Salud

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Resumen

Three Plasmodium falciparum serine repeat antigen (SERA) protein peptides were studied by NMR and structure calculations being done in 70:30 water:trifluoroethanol solution. Peptide 22834 was shown to be immunogenic and protective against malaria in Aotus monkeys, whilst native peptide 6737 and its analogue 14096 did not present protection against the disease in these monkeys. Results showed a relationship between these peptides' secondary structure and their function as immunogen against malaria.

Idioma original	Inglés estadounidense
Número de artículo	7
Páginas (desde-hasta)	651
Número de páginas	657
Publicación	Biochimie
Volumen	85
N.º	7
DOI	https://doi.org/10.1016/S0300-9084(03)00136-6
Estado	Publicada - jul. 2003

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title = "Plasmodium falciparum SERA protein peptide analogues having short helical regions induce protection against malaria",

abstract = "Three Plasmodium falciparum serine repeat antigen (SERA) protein peptides were studied by NMR and structure calculations being done in 70:30 water:trifluoroethanol solution. Peptide 22834 was shown to be immunogenic and protective against malaria in Aotus monkeys, whilst native peptide 6737 and its analogue 14096 did not present protection against the disease in these monkeys. Results showed a relationship between these peptides' secondary structure and their function as immunogen against malaria.",

author = "{Bermudez Quintero}, {Adriana Janneth} and Marcia Cubillos and Alba, {Martha Patricia} and Mary Trujillo and Patarroyo, {Manuel Elkin}",

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AU - Bermudez Quintero, Adriana Janneth

AU - Cubillos, Marcia

AU - Alba, Martha Patricia

AU - Trujillo, Mary

AU - Patarroyo, Manuel Elkin

PY - 2003/7

Y1 - 2003/7

N2 - Three Plasmodium falciparum serine repeat antigen (SERA) protein peptides were studied by NMR and structure calculations being done in 70:30 water:trifluoroethanol solution. Peptide 22834 was shown to be immunogenic and protective against malaria in Aotus monkeys, whilst native peptide 6737 and its analogue 14096 did not present protection against the disease in these monkeys. Results showed a relationship between these peptides' secondary structure and their function as immunogen against malaria.

AB - Three Plasmodium falciparum serine repeat antigen (SERA) protein peptides were studied by NMR and structure calculations being done in 70:30 water:trifluoroethanol solution. Peptide 22834 was shown to be immunogenic and protective against malaria in Aotus monkeys, whilst native peptide 6737 and its analogue 14096 did not present protection against the disease in these monkeys. Results showed a relationship between these peptides' secondary structure and their function as immunogen against malaria.

UR - http://www.sciencedirect.com/science/article/pii/S0300908403001366?via%3Dihub

U2 - 10.1016/S0300-9084(03)00136-6

DO - 10.1016/S0300-9084(03)00136-6

M3 - Article

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VL - 85

SP - 651

JO - Biochimie

JF - Biochimie

IS - 7

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ER -

Plasmodium falciparum SERA protein peptide analogues having short helical regions induce protection against malaria

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