Plasmodium falciparum SERA protein peptide analogues having short helical regions induce protection against malaria

Adriana Janneth Bermudez Quintero, Marcia Cubillos, Martha Patricia Alba, Mary Trujillo, Manuel Elkin Patarroyo

Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva

16 Citas (Scopus)

Resumen

Three Plasmodium falciparum serine repeat antigen (SERA) protein peptides were studied by NMR and structure calculations being done in 70:30 water:trifluoroethanol solution. Peptide 22834 was shown to be immunogenic and protective against malaria in Aotus monkeys, whilst native peptide 6737 and its analogue 14096 did not present protection against the disease in these monkeys. Results showed a relationship between these peptides' secondary structure and their function as immunogen against malaria.
Idioma originalInglés estadounidense
Número de artículo7
Páginas (desde-hasta)651
Número de páginas657
PublicaciónBiochimie
Volumen85
N.º7
DOI
EstadoPublicada - jul 2003

Huella

Profundice en los temas de investigación de 'Plasmodium falciparum SERA protein peptide analogues having short helical regions induce protection against malaria'. En conjunto forman una huella única.

Citar esto