Plasmodium falciparum SERA protein peptide analogues having short helical regions induce protection against malaria

Adriana Janneth Bermudez Quintero, Marcia Cubillos, Martha Patricia Alba, Mary Trujillo, Manuel Elkin Patarroyo

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

Three Plasmodium falciparum serine repeat antigen (SERA) protein peptides were studied by NMR and structure calculations being done in 70:30 water:trifluoroethanol solution. Peptide 22834 was shown to be immunogenic and protective against malaria in Aotus monkeys, whilst native peptide 6737 and its analogue 14096 did not present protection against the disease in these monkeys. Results showed a relationship between these peptides' secondary structure and their function as immunogen against malaria.
Original languageEnglish (US)
Article number7
Pages (from-to)651
Number of pages657
JournalBiochimie
Volume85
Issue number7
DOIs
StatePublished - Jul 2003

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