Peptidorhamnomannan negatively modulates the immune response in a scedosporiosis murine model

Mariana I.D.S. Xisto, Livia Cristina Liporagi-Lopes, Julián Esteban Muñoz, Vera C.B. Bittencourt, Giulia M.P. Santos, Lucas S. Dias, Rodrigo T. Figueiredo, Márcia R. Pinto, Carlos P. Taborda, Eliana Barreto-Bergter

Producción científica: Contribución a una revistaArtículo de Investigaciónrevisión exhaustiva

9 Citas (Scopus)

Resumen

In this study, we analyzed the impact of immunization with the peptidorhamnomannan (PRM) from the cell wall of the fungus Scedosporium (Lomentospora) prolificans in a murine model of invasive scedosporiosis. Immunization with PRM decreased the survival of mice infected with S. prolificans. Immunization of mice with PRM led to decreased secretion of pro-inflammatory cytokines and chemokines but did not affect the secretion of IL-10. Mice immunized with PRM showed an increase in IgG1 secretion, which is an immunoglobulin linked to a nonprotective response. Splenocytes isolated from mice infected with S. prolificans and immunized with PRM showed no differences in the percentages of Th17 cells and no increase in the frequency of the CD4+CD62LLow T cell population. PRM-immunized mice showed a significant increase in the percentage of Treg cells. In summary, our results indicated that immunization with PRM did not assist or improve the immunological response against S. prolificans infection. PRM exacerbated the infection process by reducing the inflammatory response, thereby facilitating colonization, virulence and dissemination by the fungus.

Idioma originalInglés estadounidense
Páginas (desde-hasta)846-855
Número de páginas10
PublicaciónMedical Mycology
Volumen54
N.º8
DOI
EstadoPublicada - nov. 1 2016
Publicado de forma externa

Áreas temáticas de ASJC Scopus

  • Enfermedades infecciosas

Huella

Profundice en los temas de investigación de 'Peptidorhamnomannan negatively modulates the immune response in a scedosporiosis murine model'. En conjunto forman una huella única.

Citar esto