Near-IR Triggered Photon Upconversion: Imaging, Detection, and Therapy

Diana C. Rodriguez Burbano; Rafik Naccache; John A. Capobianco

doi:10.1016/B978-0-444-63481-8.00273-6

Near-IR Triggered Photon Upconversion: Imaging, Detection, and Therapy

Título traducido de la contribución: Upconversión de fotones desencadenada en el infrarrojo cercano: Imágenes, detección y terapia

Diana C. Rodriguez Burbano, Rafik Naccache, John A. Capobianco

Producción científica: Capítulo en Libro/Reporte › Contribución a la conferencia

22 Citas (Scopus)

Resumen

La conversión ascendente es un proceso multifotónico que convierte la luz NIR en luz de mayor energía, como la UV, la visible o incluso la NIR (con una longitud de onda inferior a la de la fuente de excitación). La revisión presenta en primer lugar las nanopartículas de conversión ascendente dopadas con lantánidos, centrándose en los mecanismos de conversión ascendente y en los distintos enfoques sintéticos para su preparación, incluida la elección del material huésped y de los iones dopantes de lantánidos. A continuación, se describen las distintas estrategias para modificar la superficie de las nanopartículas y hacerlas hidrófilas, así como para bioconjugarlas con marcadores biológicos específicos. Las secciones están dedicadas a aplicaciones en bioanálisis, imagen médica y liberación de fármacos. De hecho, las nanopartículas upconverting dopadas con lantánidos se han utilizado ampliamente para detectar la temperatura celular y como sondas ópticas para el análisis de iones metálicos, así como en inmunoensayos. Más recientemente, han formado parte de la estrategia de desarrollo de imágenes de células y pequeños organismos/animales, incluidas las bioimágenes multimodales. Por último, se han construido balizas basadas en nanopartículas upconverting con el objetivo de inducir la liberación in situ de fármacos o la transferencia de energía para desencadenar la formación de oxígeno singlete. Esto resulta de interés en la terapia fotodinámica y fototérmica del cáncer. La última sección ofrece al lector los retos a los que se enfrenta la comunidad para convertir los nanomateriales upconverting dopados con lantánidos en plataformas versátiles para la generación de herramientas nanoteranósticas para las necesidades de la nanomedicina.

Título traducido de la contribución	Upconversión de fotones desencadenada en el infrarrojo cercano: Imágenes, detección y terapia
Idioma original	Inglés estadounidense
Título de la publicación alojada	Handbook on the Physics and Chemistry of Rare Earths
Editores	Jean-Claude Bunzli, Pecharsky Pecharsky
Editorial	Elsevier
Capítulo	273
Páginas	273-347
Número de páginas	75
Volumen	47
Edición	2015
ISBN (versión impresa)	9780444634818
DOI	https://doi.org/10.1016/B978-0-444-63481-8.00273-6
Estado	Publicada - 2015
Publicado de forma externa	Sí

Serie de la publicación

Nombre	Handbook on the Physics and Chemistry of Rare Earths
Volumen	47
ISSN (versión impresa)	0168-1273

Áreas temáticas de ASJC Scopus

Química General
Ciencia de los Materiales General
Geoquímica y petrología
Física y Astronomía General

ODS de las Naciones Unidas

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10.1016/B978-0-444-63481-8.00273-6

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Rodriguez Burbano, D. C., Naccache, R., & Capobianco, J. A. (2015). Near-IR Triggered Photon Upconversion: Imaging, Detection, and Therapy. En J.-C. Bunzli, & P. Pecharsky (Eds.), Handbook on the Physics and Chemistry of Rare Earths (2015 ed., Vol. 47, pp. 273-347). (Handbook on the Physics and Chemistry of Rare Earths; Vol. 47). Elsevier. https://doi.org/10.1016/B978-0-444-63481-8.00273-6

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title = "Near-IR Triggered Photon Upconversion: Imaging, Detection, and Therapy",

abstract = "Upconversion is a multiphoton process that converts NIR light to higher energy light such as UV, visible, or even NIR (with a wavelength shorter than the excitation source). The review first presents lanthanide-doped upconverting nanoparticles with a focus on the mechanisms of upconversion and the various synthetic approaches for their preparation, including the choice of the host material and of the lanthanide dopant ions. It then describes the different strategies to achieve surface modifications for rendering the nanoparticles hydrophilic and for bioconjugating them as required for targeting specific biological markers. The sections are devoted to applications in bioanalysis, medical imaging, and drug release. Lanthanide-doped upconverting nanoparticles have indeed found widespread use for the sensing of cell temperature and as optical probes for metal ions analysis as well as in immunoassays. More recently, they have been part of the strategy for developing cell and small organism/animal imaging, including multimodal bioimaging. Finally, beacons based on upconverting nanoparticles have been constructed with the aim of inducing in situ drug release or energy transfer for triggering the formation of singlet oxygen. This is of interest in photodynamic and photothermal therapy of cancer. The last section provides the reader with the challenges that the community faces in order to turn lanthanide-doped upconverting nanomaterials into versatile platforms for the generation of nanotheranostic tools for the needs of nanomedicine.",

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note = "Funding Information: J.A.C. is a Concordia University Research Chair in Nanoscience and is grateful to Concordia University for financial support for his research. He is also grateful for financial support from the Natural Sciences and Engineering Research Council (NSERC). R.N. is an NSERC postdoctoral scholar and is thankful to NSERC for funding. D.C.R.B. acknowledges financial support from Colciencias under the Convocatoria Exterior 2012–568 Program.",

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Rodriguez Burbano, DC, Naccache, R & Capobianco, JA 2015, Near-IR Triggered Photon Upconversion: Imaging, Detection, and Therapy. En J-C Bunzli & P Pecharsky (eds.), Handbook on the Physics and Chemistry of Rare Earths. 2015 ed., vol. 47, Handbook on the Physics and Chemistry of Rare Earths, vol. 47, Elsevier, pp. 273-347. https://doi.org/10.1016/B978-0-444-63481-8.00273-6

Near-IR Triggered Photon Upconversion: Imaging, Detection, and Therapy. / Rodriguez Burbano, Diana C.; Naccache, Rafik; Capobianco, John A.
Handbook on the Physics and Chemistry of Rare Earths. ed. / Jean-Claude Bunzli; Pecharsky Pecharsky. Vol. 47 2015. ed. Elsevier, 2015. p. 273-347 (Handbook on the Physics and Chemistry of Rare Earths; Vol. 47).

Producción científica: Capítulo en Libro/Reporte › Contribución a la conferencia

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Near-IR Triggered Photon Upconversion: Imaging, Detection, and Therapy

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