@inproceedings{90e904aaae864f9890ca192415e5d2dd,
title = "Microfluidic blood margination (μBM): A {"}cell-based{"} blood purification platform for broad spectrum immunomodulation in murine model of sepsis",
abstract = "Sepsis represents the systemic inflammatory response caused by microbial infection in blood. Given the complexity of its pathophysiology, current extracorporeal blood purifications are based on non-selective removal of inflammatory mediators which have had limited success and feasibility in clinical settings. In this work, we developed a microfluidic blood purification approach for non-specific removal of bacteria and inflammatory cellular components (platelets and leukocytes) from whole blood using cell margination. We performed continuous blood filtration in vivo in mice and demonstrated long term modulation of host inflammatory response in a murine model of polymicrobial sepsis induced by cecal ligation and puncture (CLP).",
author = "Hou, {H. W.} and L. Wu and D. Amador-Munoz and Vera, {M. P.} and Levy, {B. D.} and Baron, {R. M.} and J. Han",
note = "Publisher Copyright: {\textcopyright} 14CBMS.; 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014 ; Conference date: 26-10-2014 Through 30-10-2014",
year = "2014",
language = "English (US)",
series = "18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014",
publisher = "Chemical and Biological Microsystems Society",
pages = "333--335",
booktitle = "18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014",
}