Microfluidic blood margination (μBM): A "cell-based" blood purification platform for broad spectrum immunomodulation in murine model of sepsis

H. W. Hou, L. Wu, D. Amador-Munoz, M. P. Vera, B. D. Levy, R. M. Baron, J. Han

Research output: Chapter in Book/ReportConference contribution

1 Scopus citations

Abstract

Sepsis represents the systemic inflammatory response caused by microbial infection in blood. Given the complexity of its pathophysiology, current extracorporeal blood purifications are based on non-selective removal of inflammatory mediators which have had limited success and feasibility in clinical settings. In this work, we developed a microfluidic blood purification approach for non-specific removal of bacteria and inflammatory cellular components (platelets and leukocytes) from whole blood using cell margination. We performed continuous blood filtration in vivo in mice and demonstrated long term modulation of host inflammatory response in a murine model of polymicrobial sepsis induced by cecal ligation and puncture (CLP).

Original languageEnglish (US)
Title of host publication18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014
PublisherChemical and Biological Microsystems Society
Pages333-335
Number of pages3
ISBN (Electronic)9780979806476
StatePublished - 2014
Externally publishedYes
Event18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014 - San Antonio, United States
Duration: Oct 26 2014Oct 30 2014

Publication series

Name18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014

Conference

Conference18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014
Country/TerritoryUnited States
CitySan Antonio
Period10/26/1410/30/14

All Science Journal Classification (ASJC) codes

  • Control and Systems Engineering

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