Effects of an exercise program on hepatic metabolism, hepatic fat, and cardiovascular health in overweight/obese adolescents from Bogotá, Colombia (the HEPAFIT study): Study protocol for a randomized controlled trial

Título traducido de la contribución: Efectos de un programa de ejercicio sobre el metabolismo hepático, la grasa hepática y la salud cardiovascular en adolescentes con sobrepeso y obesidad de Bogotá, Colombia (estudio HEPAFIT): Protocolo de estudio para un ensayo controlado aleatorio

Katherine González-Ruíz, Jorge Enrique Correa-Bautista, Mikel Izquierdo, Antonio García-Hermoso, María Andrea Dominguez-Sanchez, Rosa Helena Bustos-Cruz, Jorge Cañete García-Prieto, Vicente Martínez-Vizcaíno, Felipe Lobelo, Emilio González-Jiménez, Daniel Humberto Prieto-Benavides, Alejandra Tordecilla-Sanders, Jacqueline Schmidt-RioValle, Guillermo Perez, Robinson Ramírez-Vélez

Resultado de la investigación: Contribución a RevistaArtículo

3 Citas (Scopus)

Resumen

Antecedentes: Una proporción considerable de jóvenes contemporáneos tienen un alto riesgo de padecer trastornos relacionados con la obesidad, como enfermedades cardiovasculares, síndrome metabólico o enfermedad del hígado graso no alcohólico (EHGNA). Aunque existen pruebas consistentes de los efectos positivos de la actividad física en varios aspectos de la salud, la mayoría de los adolescentes en Colombia son sedentarios. Por lo tanto, es importante implementar estrategias que generen cambios en el estilo de vida. El estudio HEPAFIT tiene como objetivo examinar si un programa de ejercicio de 6 meses tiene beneficios para el contenido de grasa hepática y los resultados de salud cardiovascular entre los adolescentes con sobrepeso/obesidad de Bogotá, Colombia. Métodos/diseño: En total, 100 adolescentes sedentarios con sobrepeso/obesidad (de 11 a 17 años de edad) que asisten a dos escuelas públicas en Bogotá, Colombia, serán incluidos en un ensayo controlado aleatorizado de grupos paralelos. Los adolescentes serán asignados aleatoriamente a un grupo de intervención siguiendo uno de los cuatro planes de estudios: (1) el plan de estudios estándar de educación física (60 minutos por semana de actividad física, n = 25) de intensidad baja a moderada; (2) un plan de estudios de educación física de alta intensidad (HIPE, n = 25), que consiste en juegos de resistencia y resistencia y actividades no competitivas, como correr, gymkhanas, levantar, empujar, luchar o acarrear, durante 60 sesiones de 60 minutos, tres veces a la semana, con un objetivo de gasto de energía de 300 a 500 kcal/sesión a una frecuencia cardíaca máxima de 75-85% (HRmax); (3) un currículo de educación física de intensidad baja a moderada (LIPE, n = 25) que consiste en juegos de resistencia y resistencia y actividades no competitivas (e.g., persiguiendo, corriendo, regateando o saltando) durante sesiones de 60 minutos, tres veces por semana con una meta de gasto de energía de 300 kcal/sesión a 55-75% HRmax; y (4) un plan de estudios combinado de HIPE y LIPE (n = 25). Las intervenciones HIPE, LIPE y combinadas se realizaron además del plan de estudios estándar de educación física. La medida de resultado primaria para la efectividad es el contenido de grasa hepática, medido por el parámetro de atenuación controlada una semana después del final del programa de intervención. Discusión: El enfoque traslacional puede ser adecuado para recopilar nueva información en un entorno escolar sobre los posibles efectos de las intervenciones de actividad física para reducir el contenido de grasa hepática y mejorar los perfiles metabólicos y la salud cardiometabólica de los adolescentes con sobrepeso u obesidad. Esto puede conducir a un uso más eficiente de los recursos de educación física en las escuelas.
Idioma originalEnglish (US)
Número de artículo330
PublicaciónTrials
Volumen19
N.º1
DOI
EstadoPublished - jun 25 2018

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Pharmacology (medical)

Citar esto

González-Ruíz, K., Correa-Bautista, J. E., Izquierdo, M., García-Hermoso, A., Dominguez-Sanchez, M. A., Bustos-Cruz, R. H., ... Ramírez-Vélez, R. (2018). Effects of an exercise program on hepatic metabolism, hepatic fat, and cardiovascular health in overweight/obese adolescents from Bogotá, Colombia (the HEPAFIT study): Study protocol for a randomized controlled trial. Trials, 19(1), [330]. https://doi.org/10.1186/s13063-018-2721-5
González-Ruíz, Katherine ; Correa-Bautista, Jorge Enrique ; Izquierdo, Mikel ; García-Hermoso, Antonio ; Dominguez-Sanchez, María Andrea ; Bustos-Cruz, Rosa Helena ; García-Prieto, Jorge Cañete ; Martínez-Vizcaíno, Vicente ; Lobelo, Felipe ; González-Jiménez, Emilio ; Prieto-Benavides, Daniel Humberto ; Tordecilla-Sanders, Alejandra ; Schmidt-RioValle, Jacqueline ; Perez, Guillermo ; Ramírez-Vélez, Robinson. / Effects of an exercise program on hepatic metabolism, hepatic fat, and cardiovascular health in overweight/obese adolescents from Bogotá, Colombia (the HEPAFIT study) : Study protocol for a randomized controlled trial. En: Trials. 2018 ; Vol. 19, N.º 1.
@article{ed1699a0f49f4ac2bf56d6b4c3d9008b,
title = "Effects of an exercise program on hepatic metabolism, hepatic fat, and cardiovascular health in overweight/obese adolescents from Bogot{\'a}, Colombia (the HEPAFIT study): Study protocol for a randomized controlled trial",
abstract = "Background: A considerable proportion of contemporary youth have a high risk of obesity-related disorders such as cardiovascular disease, metabolic syndrome, or non-alcoholic fatty liver disease (NAFLD). Although there is consistent evidence for the positive effects of physical activity on several health aspects, most adolescents in Colombia are sedentary. It is, therefore, important to implement strategies that generate changes in lifestyle. The HEPAFIT study aims to examine whether a 6-month exercise program has benefits for hepatic fat content and cardiovascular health outcomes among overweight/obese adolescents from Bogot{\'a}, Colombia. Methods/design: Altogether, 100 hundred overweight/obese, sedentary adolescents (aged 11-17 years) attending two public schools in Bogot{\'a}, Colombia, will be included in a parallel-group randomized controlled trial. Adolescents will be randomly assigned to an intervention group following one of four curricula: (1) the standard physical education curriculum (60 min per week of physical activity, n = 25) at low-to-moderate intensity; (2) a high-intensity physical education curriculum (HIPE, n = 25), consisting of endurance and resistance games and non-competitive activities, such as running, gymkhanas, lifting, pushing, wrestling, or hauling, for 60-min sessions, three times per week, with an energy expenditure goal of 300 to 500 kcal/session at 75-85{\%} maximum heart rate (HRmax); (3) a low-to-moderate intensity physical education curriculum (LIPE, n = 25) consisting of endurance and resistance games and non-competitive activities (e.g., chasing, sprinting, dribbling, or hopping) for 60-min sessions, three times per week with an energy expenditure goal of 300 kcal/session at 55-75{\%} HRmax; and (4) a combined HIPE and LIPE curriculum (n = 25). The HIPE, LIPE, and combined interventions were performed in addition to the standard physical education curriculum. The primary outcome for effectiveness is liver fat content, as measured by the controlled attenuation parameter 1 week after the end of the intervention program. Discussion: The translational focus may be suitable for collecting new information in a school setting on the possible effects of physical activity interventions to reduce liver fat content and to improve metabolic profiles and the cardiometabolic health of overweight/obese adolescents. This may lead to the more efficient use of school physical education resources.",
author = "Katherine Gonz{\'a}lez-Ru{\'i}z and Correa-Bautista, {Jorge Enrique} and Mikel Izquierdo and Antonio Garc{\'i}a-Hermoso and Dominguez-Sanchez, {Mar{\'i}a Andrea} and Bustos-Cruz, {Rosa Helena} and Garc{\'i}a-Prieto, {Jorge Ca{\~n}ete} and Vicente Mart{\'i}nez-Vizca{\'i}no and Felipe Lobelo and Emilio Gonz{\'a}lez-Jim{\'e}nez and Prieto-Benavides, {Daniel Humberto} and Alejandra Tordecilla-Sanders and Jacqueline Schmidt-RioValle and Guillermo Perez and Robinson Ram{\'i}rez-V{\'e}lez",
year = "2018",
month = "6",
day = "25",
doi = "10.1186/s13063-018-2721-5",
language = "English (US)",
volume = "19",
journal = "Trials",
issn = "1745-6215",
publisher = "BioMed Central",
number = "1",

}

González-Ruíz, K, Correa-Bautista, JE, Izquierdo, M, García-Hermoso, A, Dominguez-Sanchez, MA, Bustos-Cruz, RH, García-Prieto, JC, Martínez-Vizcaíno, V, Lobelo, F, González-Jiménez, E, Prieto-Benavides, DH, Tordecilla-Sanders, A, Schmidt-RioValle, J, Perez, G & Ramírez-Vélez, R 2018, 'Effects of an exercise program on hepatic metabolism, hepatic fat, and cardiovascular health in overweight/obese adolescents from Bogotá, Colombia (the HEPAFIT study): Study protocol for a randomized controlled trial', Trials, vol. 19, n.º 1, 330. https://doi.org/10.1186/s13063-018-2721-5

Effects of an exercise program on hepatic metabolism, hepatic fat, and cardiovascular health in overweight/obese adolescents from Bogotá, Colombia (the HEPAFIT study) : Study protocol for a randomized controlled trial. / González-Ruíz, Katherine; Correa-Bautista, Jorge Enrique; Izquierdo, Mikel; García-Hermoso, Antonio; Dominguez-Sanchez, María Andrea; Bustos-Cruz, Rosa Helena; García-Prieto, Jorge Cañete; Martínez-Vizcaíno, Vicente; Lobelo, Felipe; González-Jiménez, Emilio; Prieto-Benavides, Daniel Humberto; Tordecilla-Sanders, Alejandra; Schmidt-RioValle, Jacqueline; Perez, Guillermo; Ramírez-Vélez, Robinson.

En: Trials, Vol. 19, N.º 1, 330, 25.06.2018.

Resultado de la investigación: Contribución a RevistaArtículo

TY - JOUR

T1 - Effects of an exercise program on hepatic metabolism, hepatic fat, and cardiovascular health in overweight/obese adolescents from Bogotá, Colombia (the HEPAFIT study)

T2 - Study protocol for a randomized controlled trial

AU - González-Ruíz, Katherine

AU - Correa-Bautista, Jorge Enrique

AU - Izquierdo, Mikel

AU - García-Hermoso, Antonio

AU - Dominguez-Sanchez, María Andrea

AU - Bustos-Cruz, Rosa Helena

AU - García-Prieto, Jorge Cañete

AU - Martínez-Vizcaíno, Vicente

AU - Lobelo, Felipe

AU - González-Jiménez, Emilio

AU - Prieto-Benavides, Daniel Humberto

AU - Tordecilla-Sanders, Alejandra

AU - Schmidt-RioValle, Jacqueline

AU - Perez, Guillermo

AU - Ramírez-Vélez, Robinson

PY - 2018/6/25

Y1 - 2018/6/25

N2 - Background: A considerable proportion of contemporary youth have a high risk of obesity-related disorders such as cardiovascular disease, metabolic syndrome, or non-alcoholic fatty liver disease (NAFLD). Although there is consistent evidence for the positive effects of physical activity on several health aspects, most adolescents in Colombia are sedentary. It is, therefore, important to implement strategies that generate changes in lifestyle. The HEPAFIT study aims to examine whether a 6-month exercise program has benefits for hepatic fat content and cardiovascular health outcomes among overweight/obese adolescents from Bogotá, Colombia. Methods/design: Altogether, 100 hundred overweight/obese, sedentary adolescents (aged 11-17 years) attending two public schools in Bogotá, Colombia, will be included in a parallel-group randomized controlled trial. Adolescents will be randomly assigned to an intervention group following one of four curricula: (1) the standard physical education curriculum (60 min per week of physical activity, n = 25) at low-to-moderate intensity; (2) a high-intensity physical education curriculum (HIPE, n = 25), consisting of endurance and resistance games and non-competitive activities, such as running, gymkhanas, lifting, pushing, wrestling, or hauling, for 60-min sessions, three times per week, with an energy expenditure goal of 300 to 500 kcal/session at 75-85% maximum heart rate (HRmax); (3) a low-to-moderate intensity physical education curriculum (LIPE, n = 25) consisting of endurance and resistance games and non-competitive activities (e.g., chasing, sprinting, dribbling, or hopping) for 60-min sessions, three times per week with an energy expenditure goal of 300 kcal/session at 55-75% HRmax; and (4) a combined HIPE and LIPE curriculum (n = 25). The HIPE, LIPE, and combined interventions were performed in addition to the standard physical education curriculum. The primary outcome for effectiveness is liver fat content, as measured by the controlled attenuation parameter 1 week after the end of the intervention program. Discussion: The translational focus may be suitable for collecting new information in a school setting on the possible effects of physical activity interventions to reduce liver fat content and to improve metabolic profiles and the cardiometabolic health of overweight/obese adolescents. This may lead to the more efficient use of school physical education resources.

AB - Background: A considerable proportion of contemporary youth have a high risk of obesity-related disorders such as cardiovascular disease, metabolic syndrome, or non-alcoholic fatty liver disease (NAFLD). Although there is consistent evidence for the positive effects of physical activity on several health aspects, most adolescents in Colombia are sedentary. It is, therefore, important to implement strategies that generate changes in lifestyle. The HEPAFIT study aims to examine whether a 6-month exercise program has benefits for hepatic fat content and cardiovascular health outcomes among overweight/obese adolescents from Bogotá, Colombia. Methods/design: Altogether, 100 hundred overweight/obese, sedentary adolescents (aged 11-17 years) attending two public schools in Bogotá, Colombia, will be included in a parallel-group randomized controlled trial. Adolescents will be randomly assigned to an intervention group following one of four curricula: (1) the standard physical education curriculum (60 min per week of physical activity, n = 25) at low-to-moderate intensity; (2) a high-intensity physical education curriculum (HIPE, n = 25), consisting of endurance and resistance games and non-competitive activities, such as running, gymkhanas, lifting, pushing, wrestling, or hauling, for 60-min sessions, three times per week, with an energy expenditure goal of 300 to 500 kcal/session at 75-85% maximum heart rate (HRmax); (3) a low-to-moderate intensity physical education curriculum (LIPE, n = 25) consisting of endurance and resistance games and non-competitive activities (e.g., chasing, sprinting, dribbling, or hopping) for 60-min sessions, three times per week with an energy expenditure goal of 300 kcal/session at 55-75% HRmax; and (4) a combined HIPE and LIPE curriculum (n = 25). The HIPE, LIPE, and combined interventions were performed in addition to the standard physical education curriculum. The primary outcome for effectiveness is liver fat content, as measured by the controlled attenuation parameter 1 week after the end of the intervention program. Discussion: The translational focus may be suitable for collecting new information in a school setting on the possible effects of physical activity interventions to reduce liver fat content and to improve metabolic profiles and the cardiometabolic health of overweight/obese adolescents. This may lead to the more efficient use of school physical education resources.

UR - http://www.scopus.com/inward/record.url?scp=85049063796&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85049063796&partnerID=8YFLogxK

U2 - 10.1186/s13063-018-2721-5

DO - 10.1186/s13063-018-2721-5

M3 - Article

C2 - 29941024

AN - SCOPUS:85049063796

VL - 19

JO - Trials

JF - Trials

SN - 1745-6215

IS - 1

M1 - 330

ER -