Effects of an exercise program on hepatic metabolism, hepatic fat, and cardiovascular health in overweight/obese adolescents from Bogotá, Colombia (the HEPAFIT study): Study protocol for a randomized controlled trial

Katherine González-Ruíz, Jorge Enrique Correa-Bautista, Mikel Izquierdo, Antonio García-Hermoso, María Andrea Dominguez-Sanchez, Rosa Helena Bustos-Cruz, Jorge Cañete García-Prieto, Vicente Martínez-Vizcaíno, Felipe Lobelo, Emilio González-Jiménez, Daniel Humberto Prieto-Benavides, Alejandra Tordecilla-Sanders, Jacqueline Schmidt-RioValle, Guillermo Perez, Robinson Ramírez-Vélez

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: A considerable proportion of contemporary youth have a high risk of obesity-related disorders such as cardiovascular disease, metabolic syndrome, or non-alcoholic fatty liver disease (NAFLD). Although there is consistent evidence for the positive effects of physical activity on several health aspects, most adolescents in Colombia are sedentary. It is, therefore, important to implement strategies that generate changes in lifestyle. The HEPAFIT study aims to examine whether a 6-month exercise program has benefits for hepatic fat content and cardiovascular health outcomes among overweight/obese adolescents from Bogotá, Colombia. Methods/design: Altogether, 100 hundred overweight/obese, sedentary adolescents (aged 11-17 years) attending two public schools in Bogotá, Colombia, will be included in a parallel-group randomized controlled trial. Adolescents will be randomly assigned to an intervention group following one of four curricula: (1) the standard physical education curriculum (60 min per week of physical activity, n = 25) at low-to-moderate intensity; (2) a high-intensity physical education curriculum (HIPE, n = 25), consisting of endurance and resistance games and non-competitive activities, such as running, gymkhanas, lifting, pushing, wrestling, or hauling, for 60-min sessions, three times per week, with an energy expenditure goal of 300 to 500 kcal/session at 75-85% maximum heart rate (HRmax); (3) a low-to-moderate intensity physical education curriculum (LIPE, n = 25) consisting of endurance and resistance games and non-competitive activities (e.g., chasing, sprinting, dribbling, or hopping) for 60-min sessions, three times per week with an energy expenditure goal of 300 kcal/session at 55-75% HRmax; and (4) a combined HIPE and LIPE curriculum (n = 25). The HIPE, LIPE, and combined interventions were performed in addition to the standard physical education curriculum. The primary outcome for effectiveness is liver fat content, as measured by the controlled attenuation parameter 1 week after the end of the intervention program. Discussion: The translational focus may be suitable for collecting new information in a school setting on the possible effects of physical activity interventions to reduce liver fat content and to improve metabolic profiles and the cardiometabolic health of overweight/obese adolescents. This may lead to the more efficient use of school physical education resources.

Original languageEnglish (US)
Article number330
JournalTrials
Volume19
Issue number1
DOIs
StatePublished - Jun 25 2018

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Pharmacology (medical)

Cite this

González-Ruíz, K., Correa-Bautista, J. E., Izquierdo, M., García-Hermoso, A., Dominguez-Sanchez, M. A., Bustos-Cruz, R. H., ... Ramírez-Vélez, R. (2018). Effects of an exercise program on hepatic metabolism, hepatic fat, and cardiovascular health in overweight/obese adolescents from Bogotá, Colombia (the HEPAFIT study): Study protocol for a randomized controlled trial. Trials, 19(1), [330]. https://doi.org/10.1186/s13063-018-2721-5
González-Ruíz, Katherine ; Correa-Bautista, Jorge Enrique ; Izquierdo, Mikel ; García-Hermoso, Antonio ; Dominguez-Sanchez, María Andrea ; Bustos-Cruz, Rosa Helena ; García-Prieto, Jorge Cañete ; Martínez-Vizcaíno, Vicente ; Lobelo, Felipe ; González-Jiménez, Emilio ; Prieto-Benavides, Daniel Humberto ; Tordecilla-Sanders, Alejandra ; Schmidt-RioValle, Jacqueline ; Perez, Guillermo ; Ramírez-Vélez, Robinson. / Effects of an exercise program on hepatic metabolism, hepatic fat, and cardiovascular health in overweight/obese adolescents from Bogotá, Colombia (the HEPAFIT study) : Study protocol for a randomized controlled trial. In: Trials. 2018 ; Vol. 19, No. 1.
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title = "Effects of an exercise program on hepatic metabolism, hepatic fat, and cardiovascular health in overweight/obese adolescents from Bogot{\'a}, Colombia (the HEPAFIT study): Study protocol for a randomized controlled trial",
abstract = "Background: A considerable proportion of contemporary youth have a high risk of obesity-related disorders such as cardiovascular disease, metabolic syndrome, or non-alcoholic fatty liver disease (NAFLD). Although there is consistent evidence for the positive effects of physical activity on several health aspects, most adolescents in Colombia are sedentary. It is, therefore, important to implement strategies that generate changes in lifestyle. The HEPAFIT study aims to examine whether a 6-month exercise program has benefits for hepatic fat content and cardiovascular health outcomes among overweight/obese adolescents from Bogot{\'a}, Colombia. Methods/design: Altogether, 100 hundred overweight/obese, sedentary adolescents (aged 11-17 years) attending two public schools in Bogot{\'a}, Colombia, will be included in a parallel-group randomized controlled trial. Adolescents will be randomly assigned to an intervention group following one of four curricula: (1) the standard physical education curriculum (60 min per week of physical activity, n = 25) at low-to-moderate intensity; (2) a high-intensity physical education curriculum (HIPE, n = 25), consisting of endurance and resistance games and non-competitive activities, such as running, gymkhanas, lifting, pushing, wrestling, or hauling, for 60-min sessions, three times per week, with an energy expenditure goal of 300 to 500 kcal/session at 75-85{\%} maximum heart rate (HRmax); (3) a low-to-moderate intensity physical education curriculum (LIPE, n = 25) consisting of endurance and resistance games and non-competitive activities (e.g., chasing, sprinting, dribbling, or hopping) for 60-min sessions, three times per week with an energy expenditure goal of 300 kcal/session at 55-75{\%} HRmax; and (4) a combined HIPE and LIPE curriculum (n = 25). The HIPE, LIPE, and combined interventions were performed in addition to the standard physical education curriculum. The primary outcome for effectiveness is liver fat content, as measured by the controlled attenuation parameter 1 week after the end of the intervention program. Discussion: The translational focus may be suitable for collecting new information in a school setting on the possible effects of physical activity interventions to reduce liver fat content and to improve metabolic profiles and the cardiometabolic health of overweight/obese adolescents. This may lead to the more efficient use of school physical education resources.",
author = "Katherine Gonz{\'a}lez-Ru{\'i}z and Correa-Bautista, {Jorge Enrique} and Mikel Izquierdo and Antonio Garc{\'i}a-Hermoso and Dominguez-Sanchez, {Mar{\'i}a Andrea} and Bustos-Cruz, {Rosa Helena} and Garc{\'i}a-Prieto, {Jorge Ca{\~n}ete} and Vicente Mart{\'i}nez-Vizca{\'i}no and Felipe Lobelo and Emilio Gonz{\'a}lez-Jim{\'e}nez and Prieto-Benavides, {Daniel Humberto} and Alejandra Tordecilla-Sanders and Jacqueline Schmidt-RioValle and Guillermo Perez and Robinson Ram{\'i}rez-V{\'e}lez",
year = "2018",
month = "6",
day = "25",
doi = "10.1186/s13063-018-2721-5",
language = "English (US)",
volume = "19",
journal = "Trials",
issn = "1745-6215",
publisher = "BioMed Central",
number = "1",

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González-Ruíz, K, Correa-Bautista, JE, Izquierdo, M, García-Hermoso, A, Dominguez-Sanchez, MA, Bustos-Cruz, RH, García-Prieto, JC, Martínez-Vizcaíno, V, Lobelo, F, González-Jiménez, E, Prieto-Benavides, DH, Tordecilla-Sanders, A, Schmidt-RioValle, J, Perez, G & Ramírez-Vélez, R 2018, 'Effects of an exercise program on hepatic metabolism, hepatic fat, and cardiovascular health in overweight/obese adolescents from Bogotá, Colombia (the HEPAFIT study): Study protocol for a randomized controlled trial', Trials, vol. 19, no. 1, 330. https://doi.org/10.1186/s13063-018-2721-5

Effects of an exercise program on hepatic metabolism, hepatic fat, and cardiovascular health in overweight/obese adolescents from Bogotá, Colombia (the HEPAFIT study) : Study protocol for a randomized controlled trial. / González-Ruíz, Katherine; Correa-Bautista, Jorge Enrique; Izquierdo, Mikel; García-Hermoso, Antonio; Dominguez-Sanchez, María Andrea; Bustos-Cruz, Rosa Helena; García-Prieto, Jorge Cañete; Martínez-Vizcaíno, Vicente; Lobelo, Felipe; González-Jiménez, Emilio; Prieto-Benavides, Daniel Humberto; Tordecilla-Sanders, Alejandra; Schmidt-RioValle, Jacqueline; Perez, Guillermo; Ramírez-Vélez, Robinson.

In: Trials, Vol. 19, No. 1, 330, 25.06.2018.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Effects of an exercise program on hepatic metabolism, hepatic fat, and cardiovascular health in overweight/obese adolescents from Bogotá, Colombia (the HEPAFIT study)

T2 - Study protocol for a randomized controlled trial

AU - González-Ruíz, Katherine

AU - Correa-Bautista, Jorge Enrique

AU - Izquierdo, Mikel

AU - García-Hermoso, Antonio

AU - Dominguez-Sanchez, María Andrea

AU - Bustos-Cruz, Rosa Helena

AU - García-Prieto, Jorge Cañete

AU - Martínez-Vizcaíno, Vicente

AU - Lobelo, Felipe

AU - González-Jiménez, Emilio

AU - Prieto-Benavides, Daniel Humberto

AU - Tordecilla-Sanders, Alejandra

AU - Schmidt-RioValle, Jacqueline

AU - Perez, Guillermo

AU - Ramírez-Vélez, Robinson

PY - 2018/6/25

Y1 - 2018/6/25

N2 - Background: A considerable proportion of contemporary youth have a high risk of obesity-related disorders such as cardiovascular disease, metabolic syndrome, or non-alcoholic fatty liver disease (NAFLD). Although there is consistent evidence for the positive effects of physical activity on several health aspects, most adolescents in Colombia are sedentary. It is, therefore, important to implement strategies that generate changes in lifestyle. The HEPAFIT study aims to examine whether a 6-month exercise program has benefits for hepatic fat content and cardiovascular health outcomes among overweight/obese adolescents from Bogotá, Colombia. Methods/design: Altogether, 100 hundred overweight/obese, sedentary adolescents (aged 11-17 years) attending two public schools in Bogotá, Colombia, will be included in a parallel-group randomized controlled trial. Adolescents will be randomly assigned to an intervention group following one of four curricula: (1) the standard physical education curriculum (60 min per week of physical activity, n = 25) at low-to-moderate intensity; (2) a high-intensity physical education curriculum (HIPE, n = 25), consisting of endurance and resistance games and non-competitive activities, such as running, gymkhanas, lifting, pushing, wrestling, or hauling, for 60-min sessions, three times per week, with an energy expenditure goal of 300 to 500 kcal/session at 75-85% maximum heart rate (HRmax); (3) a low-to-moderate intensity physical education curriculum (LIPE, n = 25) consisting of endurance and resistance games and non-competitive activities (e.g., chasing, sprinting, dribbling, or hopping) for 60-min sessions, three times per week with an energy expenditure goal of 300 kcal/session at 55-75% HRmax; and (4) a combined HIPE and LIPE curriculum (n = 25). The HIPE, LIPE, and combined interventions were performed in addition to the standard physical education curriculum. The primary outcome for effectiveness is liver fat content, as measured by the controlled attenuation parameter 1 week after the end of the intervention program. Discussion: The translational focus may be suitable for collecting new information in a school setting on the possible effects of physical activity interventions to reduce liver fat content and to improve metabolic profiles and the cardiometabolic health of overweight/obese adolescents. This may lead to the more efficient use of school physical education resources.

AB - Background: A considerable proportion of contemporary youth have a high risk of obesity-related disorders such as cardiovascular disease, metabolic syndrome, or non-alcoholic fatty liver disease (NAFLD). Although there is consistent evidence for the positive effects of physical activity on several health aspects, most adolescents in Colombia are sedentary. It is, therefore, important to implement strategies that generate changes in lifestyle. The HEPAFIT study aims to examine whether a 6-month exercise program has benefits for hepatic fat content and cardiovascular health outcomes among overweight/obese adolescents from Bogotá, Colombia. Methods/design: Altogether, 100 hundred overweight/obese, sedentary adolescents (aged 11-17 years) attending two public schools in Bogotá, Colombia, will be included in a parallel-group randomized controlled trial. Adolescents will be randomly assigned to an intervention group following one of four curricula: (1) the standard physical education curriculum (60 min per week of physical activity, n = 25) at low-to-moderate intensity; (2) a high-intensity physical education curriculum (HIPE, n = 25), consisting of endurance and resistance games and non-competitive activities, such as running, gymkhanas, lifting, pushing, wrestling, or hauling, for 60-min sessions, three times per week, with an energy expenditure goal of 300 to 500 kcal/session at 75-85% maximum heart rate (HRmax); (3) a low-to-moderate intensity physical education curriculum (LIPE, n = 25) consisting of endurance and resistance games and non-competitive activities (e.g., chasing, sprinting, dribbling, or hopping) for 60-min sessions, three times per week with an energy expenditure goal of 300 kcal/session at 55-75% HRmax; and (4) a combined HIPE and LIPE curriculum (n = 25). The HIPE, LIPE, and combined interventions were performed in addition to the standard physical education curriculum. The primary outcome for effectiveness is liver fat content, as measured by the controlled attenuation parameter 1 week after the end of the intervention program. Discussion: The translational focus may be suitable for collecting new information in a school setting on the possible effects of physical activity interventions to reduce liver fat content and to improve metabolic profiles and the cardiometabolic health of overweight/obese adolescents. This may lead to the more efficient use of school physical education resources.

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