Combined protein-and nucleic acid-level effects of rs1143679 (R77H), a lupus-predisposing variant within ITGAM

Keyphrases

• Lupus 100%
• Level Effect 100%
• Nucleic Acids 100%
• Integrin α 100%
• Risk Allele 80%
• Systemic Lupus Erythematosus 60%
• Protein Level 60%
• CD11b 60%
• Polymorphism 20%
• Molecular Mechanism 20%
• Hispanic 20%
• Genotype 20%
• African Ancestry 20%
• Immune System 20%
• In Vitro Activity 20%
• Odds Ratio 20%
• European Ancestry 20%
• Surface Proteins 20%
• Transcription Factor Binding 20%
• Monocytes 20%
• MRNA Level 20%
• Dose Effect 20%
• Asian Ethnicity 20%
• Purified Proteins 20%
• Fibrinogen 20%
• NFKB1 20%
• Phagocytosis 20%
• Genetic Association 20%
• Transcript Level 20%
• Macrophage-1 Antigen 20%
• Lower Average 20%
• Enhancer Activity 20%
• M-RNA 20%
• Leukocyte Adhesion 20%
• Reduction Amount 20%
• Vitronectin 20%
• Transcriptional Enhancer 20%
• Chromatin Regulation 20%
• Regulation Factor 20%
• Ku70 20%
• Activity in Vivo 20%
• RNA-protein Complex 20%
• Cellular Models 20%
• EBF1 20%
• Active Regions 20%

Biochemistry, Genetics and Molecular Biology

• Nucleic Acid 100%
• Integrin Alpha M 100%
• Allele 80%
• RNA 40%
• Genotyping 20%
• Transcription Factor 20%
• Fibrinogen 20%
• NFKB1 20%
• Genetic Association 20%
• Phagocytosis 20%
• Leukocyte Adherence 20%
• Vitronectin 20%
• Enhancer Region 20%
• Macrophage-1 Antigen 20%
• Ku70 20%
• EBF1 20%

Immunology and Microbiology

• Lupus Erythematosus 100%
• Integrin Alpha M 100%
• Allele 80%
• Systemic Lupus Erythematosus 60%
• Immune System 20%
• Transcription Factor 20%
• Fibrinogen 20%
• Enhancer Region 20%
• Phagocytosis 20%
• Macrophage-1 Antigen 20%
• Genetic Association 20%
• Leukocyte Adherence 20%