Clinical and Serological Characteristics of Ocular Toxoplasmosis in the Democratic Republic of Congo

Nadine Nsiangani Lusambo; Dieudonné Kaimbo Wa Kaimbo; Dieudonné Mumba Ngoyi; Janvier Kilangalanga Ngoy; Marie Thérèse Ngoyi Bambi; Théodore Kadima Mutombo; Guy Kintoki Makela; Lady Ngandowe Nzamokili; Alejandra de-la-Torre

doi:10.1080/09273948.2022.2140297

Clinical and Serological Characteristics of Ocular Toxoplasmosis in the Democratic Republic of Congo

Nadine Nsiangani Lusambo, Dieudonné Kaimbo Wa Kaimbo, Dieudonné Mumba Ngoyi, Janvier Kilangalanga Ngoy, Marie Thérèse Ngoyi Bambi, Théodore Kadima Mutombo, Guy Kintoki Makela, Lady Ngandowe Nzamokili, Alejandra de-la-Torre

Producción científica: Contribución a una revista › Artículo de Investigación › revisión exhaustiva

3 Citas (Scopus)

Resumen

PROPÓSITO: Describir datos demográficos, características clínicas y perfiles serológicos en una cohorte de pacientes congoleños con toxoplasmosis ocular (OT).

MÉTODO: Estudio transversal, realizado entre marzo de 2020 y julio de 2021 en dos clínicas oftalmológicas de Kinshasa.

RESULTADOS: El estudio incluyó 95 participantes con OT. Cincuenta y tres pacientes eran hombres (55,8%). La edad media de presentación fue de 35,6 ± 14,1 años (rango 8-69 años); 71 tenían OT activa (74,7%), entre ellos, 33 tenían OT primaria (46,5%), y 38 tenían recurrencias (53,5%). En el momento de la presentación, 51 pacientes (53,7%) presentaban deterioro visual (AV < 6/18). Las lesiones retinocoroideas se localizaban en la retina central en 60 pacientes (63,1%). Los pacientes con OT primaria tienden a tener niveles de IgG más altos que aquellos con OT recurrente ( P = .01).

CONCLUSIÓN: Informamos de la mayor cohorte de pacientes con OT en el África subsahariana. En nuestro entorno, la mayoría de los pacientes tenían OT recurrente con lesiones retinocoroideas múltiples, extensas y centrales.

Idioma original	Inglés estadounidense
Páginas (desde-hasta)	1-6
Número de páginas	6
Publicación	Ocular Immunology and Inflammation
Volumen	31
N.º	7
DOI	https://doi.org/10.1080/09273948.2022.2140297
Estado	Publicada - nov. 3 2022

Áreas temáticas de ASJC Scopus

Inmulogía y alergología
Oftalmología

ODS de las Naciones Unidas

Este resultado contribuye a los siguientes Objetivos de Desarrollo Sostenible

Acceder al documento

10.1080/09273948.2022.2140297

Otros archivos y enlaces

Citar esto

Nsiangani Lusambo, N., Kaimbo Wa Kaimbo, D., Mumba Ngoyi, D., Kilangalanga Ngoy, J., Ngoyi Bambi, M. T., Kadima Mutombo, T., Kintoki Makela, G., Ngandowe Nzamokili, L., & de-la-Torre, A. (2022). Clinical and Serological Characteristics of Ocular Toxoplasmosis in the Democratic Republic of Congo. Ocular Immunology and Inflammation, 31(7), 1-6. https://doi.org/10.1080/09273948.2022.2140297

@article{9e8ba0e4bc7c4dacbf83baa338ed838b,

title = "Clinical and Serological Characteristics of Ocular Toxoplasmosis in the Democratic Republic of Congo",

abstract = "PURPOSE: To describe demographic data, clinical features, and serological profiles in a cohort of Congolese patients with ocular toxoplasmosis (OT).METHOD: Cross-sectional study, carried out between March 2020 and July 2021 in two ophthalmic clinics in Kinshasa.RESULTS: The study comprised 95 participants with OT. Fifty-three patients were male (55.8%). The mean age at presentation was 35.6 ± 14.1 years (range 8-69 years); 71 had active OT (74.7%), among them, 33 had primary OT (46.5%), and 38 had recurrences (53.5%). At presentation, 51 patients (53.7%) had visual impairment (VA < 6/18). Retinochoroidal lesions were located in the central retina in 60 patients (63.1%). Patients with primary OT tend to have higher IgG levels than those with recurrent OT ( P = .01). CONCLUSION: We report the largest cohort of patients with OT in sub-Saharan Africa. In our setting, most patients had recurrent OT with multiple, extensive, and central retinochoroidal lesions.",

author = "{Nsiangani Lusambo}, Nadine and {Kaimbo Wa Kaimbo}, Dieudonn{\'e} and {Mumba Ngoyi}, Dieudonn{\'e} and {Kilangalanga Ngoy}, Janvier and {Ngoyi Bambi}, {Marie Th{\'e}r{\`e}se} and {Kadima Mutombo}, Th{\'e}odore and {Kintoki Makela}, Guy and {Ngandowe Nzamokili}, Lady and Alejandra de-la-Torre",

note = "Publisher Copyright: {\textcopyright} 2022 Taylor & Francis Group, LLC.",

year = "2022",

month = nov,

day = "3",

doi = "10.1080/09273948.2022.2140297",

language = "English (US)",

volume = "31",

pages = "1--6",

journal = "Ocular Immunology and Inflammation",

issn = "0927-3948",

publisher = "Informa Healthcare",

number = "7",

}

Nsiangani Lusambo, N, Kaimbo Wa Kaimbo, D, Mumba Ngoyi, D, Kilangalanga Ngoy, J, Ngoyi Bambi, MT, Kadima Mutombo, T, Kintoki Makela, G, Ngandowe Nzamokili, L & de-la-Torre, A 2022, 'Clinical and Serological Characteristics of Ocular Toxoplasmosis in the Democratic Republic of Congo', Ocular Immunology and Inflammation, vol. 31, n.º 7, pp. 1-6. https://doi.org/10.1080/09273948.2022.2140297

Clinical and Serological Characteristics of Ocular Toxoplasmosis in the Democratic Republic of Congo. / Nsiangani Lusambo, Nadine; Kaimbo Wa Kaimbo, Dieudonné; Mumba Ngoyi, Dieudonné et al.
En: Ocular Immunology and Inflammation, Vol. 31, N.º 7, 03.11.2022, p. 1-6.

Producción científica: Contribución a una revista › Artículo de Investigación › revisión exhaustiva

TY - JOUR

T1 - Clinical and Serological Characteristics of Ocular Toxoplasmosis in the Democratic Republic of Congo

AU - Nsiangani Lusambo, Nadine

AU - Kaimbo Wa Kaimbo, Dieudonné

AU - Mumba Ngoyi, Dieudonné

AU - Kilangalanga Ngoy, Janvier

AU - Ngoyi Bambi, Marie Thérèse

AU - Kadima Mutombo, Théodore

AU - Kintoki Makela, Guy

AU - Ngandowe Nzamokili, Lady

AU - de-la-Torre, Alejandra

PY - 2022/11/3

Y1 - 2022/11/3

N2 - PURPOSE: To describe demographic data, clinical features, and serological profiles in a cohort of Congolese patients with ocular toxoplasmosis (OT).METHOD: Cross-sectional study, carried out between March 2020 and July 2021 in two ophthalmic clinics in Kinshasa.RESULTS: The study comprised 95 participants with OT. Fifty-three patients were male (55.8%). The mean age at presentation was 35.6 ± 14.1 years (range 8-69 years); 71 had active OT (74.7%), among them, 33 had primary OT (46.5%), and 38 had recurrences (53.5%). At presentation, 51 patients (53.7%) had visual impairment (VA < 6/18). Retinochoroidal lesions were located in the central retina in 60 patients (63.1%). Patients with primary OT tend to have higher IgG levels than those with recurrent OT ( P = .01). CONCLUSION: We report the largest cohort of patients with OT in sub-Saharan Africa. In our setting, most patients had recurrent OT with multiple, extensive, and central retinochoroidal lesions.

AB - PURPOSE: To describe demographic data, clinical features, and serological profiles in a cohort of Congolese patients with ocular toxoplasmosis (OT).METHOD: Cross-sectional study, carried out between March 2020 and July 2021 in two ophthalmic clinics in Kinshasa.RESULTS: The study comprised 95 participants with OT. Fifty-three patients were male (55.8%). The mean age at presentation was 35.6 ± 14.1 years (range 8-69 years); 71 had active OT (74.7%), among them, 33 had primary OT (46.5%), and 38 had recurrences (53.5%). At presentation, 51 patients (53.7%) had visual impairment (VA < 6/18). Retinochoroidal lesions were located in the central retina in 60 patients (63.1%). Patients with primary OT tend to have higher IgG levels than those with recurrent OT ( P = .01). CONCLUSION: We report the largest cohort of patients with OT in sub-Saharan Africa. In our setting, most patients had recurrent OT with multiple, extensive, and central retinochoroidal lesions.

UR - http://www.scopus.com/inward/record.url?scp=85141372517&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85141372517&partnerID=8YFLogxK

UR - https://www.mendeley.com/catalogue/c8b6e492-9a47-33d5-a9d0-f2d9cf42b303/

U2 - 10.1080/09273948.2022.2140297

DO - 10.1080/09273948.2022.2140297

M3 - Research Article

C2 - 36328437

AN - SCOPUS:85141372517

SN - 0927-3948

VL - 31

SP - 1

EP - 6

JO - Ocular Immunology and Inflammation

JF - Ocular Immunology and Inflammation

IS - 7

ER -

Clinical and Serological Characteristics of Ocular Toxoplasmosis in the Democratic Republic of Congo

Resumen

Áreas temáticas de ASJC Scopus

ODS de las Naciones Unidas

Acceder al documento

Otros archivos y enlaces

Huella

Citar esto