TY - JOUR
T1 - Clinical and Serological Characteristics of Ocular Toxoplasmosis in the Democratic Republic of Congo
AU - Nsiangani Lusambo, Nadine
AU - Kaimbo Wa Kaimbo, Dieudonné
AU - Mumba Ngoyi, Dieudonné
AU - Kilangalanga Ngoy, Janvier
AU - Ngoyi Bambi, Marie Thérèse
AU - Kadima Mutombo, Théodore
AU - Kintoki Makela, Guy
AU - Ngandowe Nzamokili, Lady
AU - de-la-Torre, Alejandra
N1 - Publisher Copyright:
© 2022 Taylor & Francis Group, LLC.
PY - 2022/11/3
Y1 - 2022/11/3
N2 - PURPOSE: To describe demographic data, clinical features, and serological profiles in a cohort of Congolese patients with ocular toxoplasmosis (OT).METHOD: Cross-sectional study, carried out between March 2020 and July 2021 in two ophthalmic clinics in Kinshasa.RESULTS: The study comprised 95 participants with OT. Fifty-three patients were male (55.8%). The mean age at presentation was 35.6 ± 14.1 years (range 8-69 years); 71 had active OT (74.7%), among them, 33 had primary OT (46.5%), and 38 had recurrences (53.5%). At presentation, 51 patients (53.7%) had visual impairment (VA < 6/18). Retinochoroidal lesions were located in the central retina in 60 patients (63.1%). Patients with primary OT tend to have higher IgG levels than those with recurrent OT (
P = .01).
CONCLUSION: We report the largest cohort of patients with OT in sub-Saharan Africa. In our setting, most patients had recurrent OT with multiple, extensive, and central retinochoroidal lesions.
AB - PURPOSE: To describe demographic data, clinical features, and serological profiles in a cohort of Congolese patients with ocular toxoplasmosis (OT).METHOD: Cross-sectional study, carried out between March 2020 and July 2021 in two ophthalmic clinics in Kinshasa.RESULTS: The study comprised 95 participants with OT. Fifty-three patients were male (55.8%). The mean age at presentation was 35.6 ± 14.1 years (range 8-69 years); 71 had active OT (74.7%), among them, 33 had primary OT (46.5%), and 38 had recurrences (53.5%). At presentation, 51 patients (53.7%) had visual impairment (VA < 6/18). Retinochoroidal lesions were located in the central retina in 60 patients (63.1%). Patients with primary OT tend to have higher IgG levels than those with recurrent OT (
P = .01).
CONCLUSION: We report the largest cohort of patients with OT in sub-Saharan Africa. In our setting, most patients had recurrent OT with multiple, extensive, and central retinochoroidal lesions.
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U2 - 10.1080/09273948.2022.2140297
DO - 10.1080/09273948.2022.2140297
M3 - Article
C2 - 36328437
AN - SCOPUS:85141372517
SN - 0927-3948
VL - 31
SP - 1
EP - 6
JO - Ocular Immunology and Inflammation
JF - Ocular Immunology and Inflammation
IS - 7
ER -
