Will the emergent SARS-CoV2 B.1.1.7 lineage affect molecular diagnosis of COVID-19?

Juan D. Ramírez, Marina Muñoz, Luz H. Patiño, Nathalia Ballesteros, Alberto Paniz-Mondolfi

Research output: Contribution to journalArticlepeer-review

27 Scopus citations


As the coronavirus disease 2019 pandemic keep tackling global public health systems worldwide. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) genome keeps mutating. In that regard, the recent emergence of the B.1.1.7 lineage in the UK has called the attention of global authorities. One point of concern is that if this lineage can be detected by traditional molecular schemes for SARS-CoV-2 detection. Herein, we showed that this lineage does not affect the Berlin–Charité protocol but can challenge the available commercial kits directed to the Spike (S) gene. All efforts should be made to continue to monitor SARS-CoV-2 genomes for potential variants that can impair diagnostic testing and lead to false negative results.

Original languageEnglish (US)
JournalJournal of Medical Virology
StateAccepted/In press - 2021

All Science Journal Classification (ASJC) codes

  • Virology
  • Infectious Diseases


Dive into the research topics of 'Will the emergent SARS-CoV2 B.1.1.7 lineage affect molecular diagnosis of COVID-19?'. Together they form a unique fingerprint.

Cite this