Valor de las pruebas inmunologicas en el diagnostico de la histoplasmosis meningea

Translated title of the contribution: Value of immunological assays in the diagnosis of meningeal histoplasmosis

N. Ordóñez, M. Arango, B. Gómez, A. M. Tobón, I. Gómez, L. Franco, M. I. Medina, E. Sánchez, E. Castañeda, A. Restrepo

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Introduction. Between 1985 and 1995, 3,860 cerebrospinal fiuid (CSF) samples from patients with mycotic meningitis were analyzed. Methods. Direct examination, cultures, complement fixation (CF) and immunodiffusion (ID) with Histoplasma capsulatum were carried out. Results. Seventy four samples from 31 patients (three of them with AIDS) were reactive at the immunological assays. Cultures were positive in five patients. In 26 patients the clinical diagnosis together with positive CSF assays gave indirect evidence of meningeal histoplasmosis. ID ad CF reactivity were 93.5% and 100% respectively. For 23 patients who had simultaneous examination of blood and CSF the double positivity was 78.2%. Conclusions. Because of the direct isolation of Histoplasma capsulatum is a difficult one, the diagnosis of subacute or chronic meningeal histoplasmosis may be confirmed by indirect immunological assays.

Translated title of the contributionValue of immunological assays in the diagnosis of meningeal histoplasmosis
Original languageSpanish
Pages (from-to)1376-1380
Number of pages5
JournalRevista de Neurologia
Issue number145
StatePublished - Sep 1997
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Clinical Neurology


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