Understanding the role of Zn²⁺ in the hydrolysis of glycylserine: a mechanistic study by using density functional theory

Medicine & Life Sciences

• glycylserine 100%
• Density Functional Theory 75%
• Amides 51%
• Hydrolysis 40%
• Catalysis 34%
• Water 19%
• Esters 14%
• Protons 14%
• Serine 14%

Physics & Astronomy

• hydrolysis 49%
• density functional theory 33%
• amides 32%
• carboxylates 23%
• catalysis 19%
• attack 18%
• esters 9%
• water 9%
• rigid structures 9%
• activation 6%
• protons 5%
• products 5%
• molecules 4%

Chemical Compounds

• Carbonyl Group 28%
• Base Catalysis 27%
• Density Functional Theory 26%
• Hydrolysis 26%
• Amide 23%
• Multi-Step Reaction 14%
• Electrophilicity 13%
• Inductive Effect 12%
• Serine 10%
• Proton Transfer 9%
• Transition State 8%
• Ester 6%
• Reaction Yield 4%
• Molecule 3%