Understanding the role of Zn²⁺ in the hydrolysis of glycylserine: a mechanistic study by using density functional theory

Keyphrases

• Hydrolysis 100%
• Zn2+ 100%
• Amides 100%
• Mechanistic Studies 100%
• Density Functional Theory 100%
• Carbonyl Group 100%
• Carboxylate Group 66%
• General Acid-base Catalysis 66%
• Bicyclol 33%
• Esters 33%
• Water Molecule 33%
• Reaction Mechanism 33%
• Transition State 33%
• Proton Transfer 33%
• Hydrolysis Reaction 33%
• Rate-limiting Step 33%
• Electrophilicity 33%
• Hydrolysis Process 33%
• Cyclic Intermediates 33%
• Rigid Structure 33%
• Hydrolysis Mechanism 33%
• Water Attack 33%
• Inductive Effect 33%
• Asynchronous Transition 33%
• Initial Attack 33%
• Density Functional Calculations 33%
• Stepwise Reaction 33%
• Activation Barrier 33%
• Tetrahedral Intermediate 33%

Chemistry

• Enzymatic Hydrolysis 100%
• Density Functional Theory 100%
• Mechanistic Study 100%
• Carboxamide 75%
• Carbonyl Group 75%
• Carboxylic Acid 50%
• Base Catalysis 50%
• formation 25%
• Transition State 25%
• Electrophilicity 25%
• Proton Transfer 25%
• Density Functional Theory 25%
• Serine 25%
• Multi-Step Reaction 25%
• Inductive Effect 25%