Twice- vs. thrice-weekly MPD PUVA in psoriasis: A randomized-controlled efficacy study

Martha Cecilia Valbuena, Olga Hernández, Maritza Rey, Guillermo Sánchez, Luisa Porras De Quintana

Research output: Contribution to journalResearch Articlepeer-review

9 Scopus citations


Background: Oral psoralen-ultraviolet A (PUVA) has been the treatment of choice of moderate to severe forms of psoriasis, however there is no standardized worldwide protocol. Twice- and thrice-weekly regimens had been used. In this study we compare the efficacy of these regimens. Methods: Two PUVA regimens in 28 patients with clinical diagnosis of psoriasis, with symmetric and no less than 20% of body surface area involvement, using a half-body study, were compared. Each patient body half was randomized to receive either twice- or thrice-weekly PUVA. A blinded trained dermatologist assessed the PASI score in each body half at the beginning of the study and at clearance or after 25 sessions. Results: Twenty-three patients completed the study. There were no significant differences in the efficacy of both treatments considering the median percentage of PASI decrease (92.9% for the body half with the twice-weekly regimen and 94.8% for the thrice-weekly treatment, P =0.179). There were significant differences comparing the median number of sessions needed for clearance and the median cumulative doses, favouring the twice-weekly regimen (15 vs. 22, P =0.000, and 142.5 vs. 241.4J/cm2, P =0.001, respectively). Conclusion: The treatment of psoriasis patients with twice- or thrice-weekly PUVA in this study was equally effective, the number of sessions required and the cumulative doses of UVA were lower with the twice-weekly regimen.

Original languageEnglish (US)
Pages (from-to)126-129
Number of pages4
JournalPhotodermatology Photoimmunology and Photomedicine
Issue number4
StatePublished - Aug 2007
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Radiology Nuclear Medicine and imaging
  • Dermatology


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