The application of monoclonal antibodies to the diagnosis of disseminated mycoses

Andrew John Hamilton, Beatriz Lucía Gómez

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Monoclonal antibodies (MoAbs) have had a major impact on many areas of biomedical research and almost since their advent have been used in the characterisation and identification of diagnostically important antigens of fungal pathogens. Their main significance lies in three, often inter-related areas: a) the definition and characterisation of antigens for use in detection of antibody responses, b) their direct use in the detection of diagnostically useful antigen in body fluids c) their application in immunohistochemical diagnosis. The degree to which MoAbs have been applied varies between fungal pathogens, and they have now been used, for example, in the serodiagnosis of Aspergillus sp., Cryptococcus neoformans, Histoplasma capsulatum and Paracoccidioides brasiliensis. Their use in producing diagnostic tests for other fungi such as Sporothrix schenckii and Penicillium marneffei has been more restricted but considerable potential exists for further development.

Original languageEnglish (US)
Pages (from-to)118-124
Number of pages7
JournalRevista Iberoamericana de Micologia
Volume15
Issue number3
StatePublished - 1998
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Infectious Diseases

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