TY - JOUR
T1 - Simple proteomic checks for detecting noncoding RNA
AU - Cruveiller, Stéphane
AU - Clay, Oliver
AU - Jabbari, Kamel
AU - Bernardi, Giorgio
N1 - Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 2007/2
Y1 - 2007/2
N2 - Proper validation can accelerate sequence-based discovery of proteins and protein-coding genes. Databases currently contain a backlog of experimentally unverified gene models and tentative assignments of observed transcripts to coding or noncoding RNA. We present and apply a general principle, founded on base composition and the genetic code and validated here by bulk 2-D gels, that can improve the reliability of such classifications and of the algorithms or pipelines that lead to them.
AB - Proper validation can accelerate sequence-based discovery of proteins and protein-coding genes. Databases currently contain a backlog of experimentally unverified gene models and tentative assignments of observed transcripts to coding or noncoding RNA. We present and apply a general principle, founded on base composition and the genetic code and validated here by bulk 2-D gels, that can improve the reliability of such classifications and of the algorithms or pipelines that lead to them.
UR - http://www.scopus.com/inward/record.url?scp=33847160649&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33847160649&partnerID=8YFLogxK
U2 - 10.1002/pmic.200600813
DO - 10.1002/pmic.200600813
M3 - Article
C2 - 17211833
AN - SCOPUS:33847160649
SN - 1615-9853
VL - 7
SP - 361
EP - 363
JO - Proteomics
JF - Proteomics
IS - 3
ER -