Sex Hormones and Rheumatoid Factor : a Possible Link Between Reproductive Hormones Patterns and the Onset of Rheumatoid Arthritis Among Women in

Daniel Aletaha; Tuhina Neogi; Alan J. Silman; Julia Funovits; David T. Felson; Clifton O. Bingham; Neal S. Birnbaum; Gerd R. Burmester; Vivian P. Bykerk; Marc D. Cohen; Bernard Combe; Karen H. Costenbader; Maxime Dougados; Paul Emery; Gianfranco Ferraccioli; Johanna M.W. Hazes; Kathryn Hobbs; Tom W.J. Huizinga; Arthur Kavanaugh; Jonathan Kay; Tore K. Kvien; Timothy Laing; Philip Mease; Henri A. Ménard; Larry W. Moreland; Raymond L. Naden; Theodore Pincus; Josef S. Smolen; Ewa Stanislawska-Biernat; Deborah Symmons; Paul P. Tak; Katherine S. Upchurch; Jiří Vencovský; Frederick Wolfe; Gillian Hawker; Amir I. Elshafie; Abdalla D. Elkhalifa; Sahwa Elbagir; Mawahib I.E. Aledrissy; Elnour M. Elagib; Musa A.M. Nur; Tomas Weitoft; Johan Rönnelid; Tosoh Bioscience; Olga L. Quintero; Manuel J. Amador-Patarroyo; Gladys Montoya-Ortiz; Adriana Rojas-Villarraga; Juan Manuel Anaya; Shahar Shelly; Mona Boaz; Hedi Orbach; Sandeep K. Agarwal; Michael J Wheeler; Mahin Lashkari; Akram Noori; Sonia Oveisi; Mohammadreza Kheirkhah; Metabolic Diseases; Child Health; Metabolic Diseases; Metabolic Diseases; Cecilia Engdahl; Albert Bondt; Ulrike Harre; Jasmin Raufer; René Pfeifle; Alessandro Camponeschi; Manfred Wuhrer; Michaela Seeling; Inga Lill Mårtensson; Falk Nimmerjahn; Gerhard Krönke; Hans U. Scherer; Helena Forsblad-d'Elia; Georg Schett; Marina Pierdominici; Angela Maselli; Tania Colasanti; Anna Maria Giammarioli; Federica Delunardo; Davide Vacirca; Massimo Sanchez; Antonello Giovannetti; Walter Malorni; Elena Ortona; Meredith Provost; Jennifer L. Eaton; Megan E.B. Clowse; Jenny Brouwer; Johanna M.W. Hazes; Joop S.E. Laven; Radboud J.E.M. Dolhain; Pascal H.P. de Jong; Radboud J.E.M. Dolhain

doi:10.1016/j.jaut.2009.11.015%0Ahttp://www.ncbi.nlm.nih.gov/pubmed/31507122%0Ahttp://dx.doi.org/10.1016/j.cellimm.2015.02.004%0Ahttp://biostor.org/reference/128533%0Ahttp://dx.doi.org/10.1038/nrrheum.2014.144%0Ahttps://doi.org/10.1007/s4074

Sex Hormones and Rheumatoid Factor : a Possible Link Between Reproductive Hormones Patterns and the Onset of Rheumatoid Arthritis Among Women in

Daniel Aletaha, Tuhina Neogi, Alan J. Silman, Julia Funovits, David T. Felson, Clifton O. Bingham, Neal S. Birnbaum, Gerd R. Burmester, Vivian P. Bykerk, Marc D. Cohen, Bernard Combe, Karen H. Costenbader, Maxime Dougados, Paul Emery, Gianfranco Ferraccioli, Johanna M.W. Hazes, Kathryn Hobbs, Tom W.J. Huizinga, Arthur Kavanaugh, Jonathan KayTore K. Kvien, Timothy Laing, Philip Mease, Henri A. Ménard, Larry W. Moreland, Raymond L. Naden, Theodore Pincus, Josef S. Smolen, Ewa Stanislawska-Biernat, Deborah Symmons, Paul P. Tak, Katherine S. Upchurch, Jiří Vencovský, Frederick Wolfe, Gillian Hawker, Amir I. Elshafie, Abdalla D. Elkhalifa, Sahwa Elbagir, Mawahib I.E. Aledrissy, Elnour M. Elagib, Musa A.M. Nur, Tomas Weitoft, Johan Rönnelid, Tosoh Bioscience, Olga L. Quintero, Manuel J. Amador-Patarroyo, Gladys Montoya-Ortiz, Adriana Rojas-Villarraga, Juan Manuel Anaya, Shahar Shelly, Mona Boaz, Hedi Orbach, Sandeep K. Agarwal, Michael J Wheeler, Mahin Lashkari, Akram Noori, Sonia Oveisi, Mohammadreza Kheirkhah, Metabolic Diseases, Child Health, Metabolic Diseases, Metabolic Diseases, Cecilia Engdahl, Albert Bondt, Ulrike Harre, Jasmin Raufer, René Pfeifle, Alessandro Camponeschi, Manfred Wuhrer, Michaela Seeling, Inga Lill Mårtensson, Falk Nimmerjahn, Gerhard Krönke, Hans U. Scherer, Helena Forsblad-d'Elia, Georg Schett, Marina Pierdominici, Angela Maselli, Tania Colasanti, Anna Maria Giammarioli, Federica Delunardo, Davide Vacirca, Massimo Sanchez, Antonello Giovannetti, Walter Malorni, Elena Ortona, Meredith Provost, Jennifer L. Eaton, Megan E.B. Clowse, Jenny Brouwer, Johanna M.W. Hazes, Joop S.E. Laven, Radboud J.E.M. Dolhain, Pascal H.P. de Jong, Radboud J.E.M. Dolhain

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

Many rheumatic diseases affect women of childbearing age, and the medications used to treat these diseases may affect conception, pregnancy, fetal development, and lactation. Physicians who care for these women need to be aware of the potential adverse effects of these medications, and which medications can be used safely prior to conception and during pregnancy and lactation. Although reviews of individual classes of medications are available, there is no practical and comprehensive review that summarizes all of this information, and includes anticoagulant drugs and 2 recently approved drugs for rheumatoid arthritis. Women who take cytotoxic drugs should be informed of the risks of impaired fertility and congenital malformations, and must use effective methods of contraception. During pregnancy, nonsteroidal anti-inflammatory agents may be used until the last 6 weeks, and low to moderate doses of corticosteroids are safe throughout pregnancy. Among the disease-modifying agents, sulfasalazine and hydroxychloroquine treatment may be maintained. Cytotoxic drugs may be used after the first trimester to treat life-threatening disease. During lactation, prednisone, sulfasalazine, and hydroxychloroquine may be used cautiously. Women using heparin for treatment of antiphospholipid antibody syndrome should take measures to prevent bone loss. Men taking methotrexate, sulfasalazine, cyclosporine, azathioprine, or leflunomide should be apprised of the possibilities of infertility and teratogenicity.

Original language	Spanish (Colombia)
Pages (from-to)	1467-1476
Number of pages	10
Journal	Current Opinion in Rheumatology
DOIs	https://doi.org/10.1016/j.jaut.2009.11.015%0Ahttp://www.ncbi.nlm.nih.gov/pubmed/31507122%0Ahttp://dx.doi.org/10.1016/j.cellimm.2015.02.004%0Ahttp://biostor.org/reference/128533%0Ahttp://dx.doi.org/10.1038/nrrheum.2014.144%0Ahttps://doi.org/10.1007/s4074
State	Published - 2018

Access to Document

10.1016/j.jaut.2009.11.015%0Ahttp://www.ncbi.nlm.nih.gov/pubmed/31507122%0Ahttp://dx.doi.org/10.1016/j.cellimm.2015.02.004%0Ahttp://biostor.org/reference/128533%0Ahttp://dx.doi.org/10.1038/nrrheum.2014.144%0Ahttps://doi.org/10.1007/s4074

Cite this

Aletaha, D., Neogi, T., Silman, A. J., Funovits, J., Felson, D. T., Bingham, C. O., Birnbaum, N. S., Burmester, G. R., Bykerk, V. P., Cohen, M. D., Combe, B., Costenbader, K. H., Dougados, M., Emery, P., Ferraccioli, G., Hazes, J. M. W., Hobbs, K., Huizinga, T. W. J., Kavanaugh, A., ... Dolhain, R. J. E. M. (2018). Sex Hormones and Rheumatoid Factor : a Possible Link Between Reproductive Hormones Patterns and the Onset of Rheumatoid Arthritis Among Women in. Current Opinion in Rheumatology, 1467-1476. https://doi.org/10.1016/j.jaut.2009.11.015%0Ahttp://www.ncbi.nlm.nih.gov/pubmed/31507122%0Ahttp://dx.doi.org/10.1016/j.cellimm.2015.02.004%0Ahttp://biostor.org/reference/128533%0Ahttp://dx.doi.org/10.1038/nrrheum.2014.144%0Ahttps://doi.org/10.1007/s4074

Aletaha, Daniel ; Neogi, Tuhina ; Silman, Alan J. ; Funovits, Julia ; Felson, David T. ; Bingham, Clifton O. ; Birnbaum, Neal S. ; Burmester, Gerd R. ; Bykerk, Vivian P. ; Cohen, Marc D. ; Combe, Bernard ; Costenbader, Karen H. ; Dougados, Maxime ; Emery, Paul ; Ferraccioli, Gianfranco ; Hazes, Johanna M.W. ; Hobbs, Kathryn ; Huizinga, Tom W.J. ; Kavanaugh, Arthur ; Kay, Jonathan ; Kvien, Tore K. ; Laing, Timothy ; Mease, Philip ; Ménard, Henri A. ; Moreland, Larry W. ; Naden, Raymond L. ; Pincus, Theodore ; Smolen, Josef S. ; Stanislawska-Biernat, Ewa ; Symmons, Deborah ; Tak, Paul P. ; Upchurch, Katherine S. ; Vencovský, Jiří ; Wolfe, Frederick ; Hawker, Gillian ; Elshafie, Amir I. ; Elkhalifa, Abdalla D. ; Elbagir, Sahwa ; Aledrissy, Mawahib I.E. ; Elagib, Elnour M. ; Nur, Musa A.M. ; Weitoft, Tomas ; Rönnelid, Johan ; Bioscience, Tosoh ; Quintero, Olga L. ; Amador-Patarroyo, Manuel J. ; Montoya-Ortiz, Gladys ; Rojas-Villarraga, Adriana ; Anaya, Juan Manuel ; Shelly, Shahar ; Boaz, Mona ; Orbach, Hedi ; Agarwal, Sandeep K. ; Wheeler, Michael J ; Lashkari, Mahin ; Noori, Akram ; Oveisi, Sonia ; Kheirkhah, Mohammadreza ; Diseases, Metabolic ; Health, Child ; Diseases, Metabolic ; Diseases, Metabolic ; Engdahl, Cecilia ; Bondt, Albert ; Harre, Ulrike ; Raufer, Jasmin ; Pfeifle, René ; Camponeschi, Alessandro ; Wuhrer, Manfred ; Seeling, Michaela ; Mårtensson, Inga Lill ; Nimmerjahn, Falk ; Krönke, Gerhard ; Scherer, Hans U. ; Forsblad-d'Elia, Helena ; Schett, Georg ; Pierdominici, Marina ; Maselli, Angela ; Colasanti, Tania ; Giammarioli, Anna Maria ; Delunardo, Federica ; Vacirca, Davide ; Sanchez, Massimo ; Giovannetti, Antonello ; Malorni, Walter ; Ortona, Elena ; Provost, Meredith ; Eaton, Jennifer L. ; Clowse, Megan E.B. ; Brouwer, Jenny ; Hazes, Johanna M.W. ; Laven, Joop S.E. ; Dolhain, Radboud J.E.M. ; de Jong, Pascal H.P. ; Dolhain, Radboud J.E.M. / Sex Hormones and Rheumatoid Factor : a Possible Link Between Reproductive Hormones Patterns and the Onset of Rheumatoid Arthritis Among Women in. In: Current Opinion in Rheumatology. 2018 ; pp. 1467-1476.

@article{0506036b18e34e73af3635a815215410,

title = "Sex Hormones and Rheumatoid Factor : a Possible Link Between Reproductive Hormones Patterns and the Onset of Rheumatoid Arthritis Among Women in",

abstract = "Many rheumatic diseases affect women of childbearing age, and the medications used to treat these diseases may affect conception, pregnancy, fetal development, and lactation. Physicians who care for these women need to be aware of the potential adverse effects of these medications, and which medications can be used safely prior to conception and during pregnancy and lactation. Although reviews of individual classes of medications are available, there is no practical and comprehensive review that summarizes all of this information, and includes anticoagulant drugs and 2 recently approved drugs for rheumatoid arthritis. Women who take cytotoxic drugs should be informed of the risks of impaired fertility and congenital malformations, and must use effective methods of contraception. During pregnancy, nonsteroidal anti-inflammatory agents may be used until the last 6 weeks, and low to moderate doses of corticosteroids are safe throughout pregnancy. Among the disease-modifying agents, sulfasalazine and hydroxychloroquine treatment may be maintained. Cytotoxic drugs may be used after the first trimester to treat life-threatening disease. During lactation, prednisone, sulfasalazine, and hydroxychloroquine may be used cautiously. Women using heparin for treatment of antiphospholipid antibody syndrome should take measures to prevent bone loss. Men taking methotrexate, sulfasalazine, cyclosporine, azathioprine, or leflunomide should be apprised of the possibilities of infertility and teratogenicity.",

author = "Daniel Aletaha and Tuhina Neogi and Silman, {Alan J.} and Julia Funovits and Felson, {David T.} and Bingham, {Clifton O.} and Birnbaum, {Neal S.} and Burmester, {Gerd R.} and Bykerk, {Vivian P.} and Cohen, {Marc D.} and Bernard Combe and Costenbader, {Karen H.} and Maxime Dougados and Paul Emery and Gianfranco Ferraccioli and Hazes, {Johanna M.W.} and Kathryn Hobbs and Huizinga, {Tom W.J.} and Arthur Kavanaugh and Jonathan Kay and Kvien, {Tore K.} and Timothy Laing and Philip Mease and M{\'e}nard, {Henri A.} and Moreland, {Larry W.} and Naden, {Raymond L.} and Theodore Pincus and Smolen, {Josef S.} and Ewa Stanislawska-Biernat and Deborah Symmons and Tak, {Paul P.} and Upchurch, {Katherine S.} and Ji{\v r}{\'i} Vencovsk{\'y} and Frederick Wolfe and Gillian Hawker and Elshafie, {Amir I.} and Elkhalifa, {Abdalla D.} and Sahwa Elbagir and Aledrissy, {Mawahib I.E.} and Elagib, {Elnour M.} and Nur, {Musa A.M.} and Tomas Weitoft and Johan R{\"o}nnelid and Tosoh Bioscience and Quintero, {Olga L.} and Amador-Patarroyo, {Manuel J.} and Gladys Montoya-Ortiz and Adriana Rojas-Villarraga and Anaya, {Juan Manuel} and Shahar Shelly and Mona Boaz and Hedi Orbach and Agarwal, {Sandeep K.} and Wheeler, {Michael J} and Mahin Lashkari and Akram Noori and Sonia Oveisi and Mohammadreza Kheirkhah and Metabolic Diseases and Child Health and Metabolic Diseases and Metabolic Diseases and Cecilia Engdahl and Albert Bondt and Ulrike Harre and Jasmin Raufer and Ren{\'e} Pfeifle and Alessandro Camponeschi and Manfred Wuhrer and Michaela Seeling and M{\aa}rtensson, {Inga Lill} and Falk Nimmerjahn and Gerhard Kr{\"o}nke and Scherer, {Hans U.} and Helena Forsblad-d'Elia and Georg Schett and Marina Pierdominici and Angela Maselli and Tania Colasanti and Giammarioli, {Anna Maria} and Federica Delunardo and Davide Vacirca and Massimo Sanchez and Antonello Giovannetti and Walter Malorni and Elena Ortona and Meredith Provost and Eaton, {Jennifer L.} and Clowse, {Megan E.B.} and Jenny Brouwer and Hazes, {Johanna M.W.} and Laven, {Joop S.E.} and Dolhain, {Radboud J.E.M.} and {de Jong}, {Pascal H.P.} and Dolhain, {Radboud J.E.M.}",

year = "2018",

doi = "10.1016/j.jaut.2009.11.015%0Ahttp://www.ncbi.nlm.nih.gov/pubmed/31507122%0Ahttp://dx.doi.org/10.1016/j.cellimm.2015.02.004%0Ahttp://biostor.org/reference/128533%0Ahttp://dx.doi.org/10.1038/nrrheum.2014.144%0Ahttps://doi.org/10.1007/s4074",

language = "Espa{\~n}ol (Colombia)",

pages = "1467--1476",

journal = "Current Opinion in Rheumatology",

issn = "1040-8711",

publisher = "Lippincott Williams and Wilkins",

}

Aletaha, D, Neogi, T, Silman, AJ, Funovits, J, Felson, DT, Bingham, CO, Birnbaum, NS, Burmester, GR, Bykerk, VP, Cohen, MD, Combe, B, Costenbader, KH, Dougados, M, Emery, P, Ferraccioli, G, Hazes, JMW, Hobbs, K, Huizinga, TWJ, Kavanaugh, A, Kay, J, Kvien, TK, Laing, T, Mease, P, Ménard, HA, Moreland, LW, Naden, RL, Pincus, T, Smolen, JS, Stanislawska-Biernat, E, Symmons, D, Tak, PP, Upchurch, KS, Vencovský, J, Wolfe, F, Hawker, G, Elshafie, AI, Elkhalifa, AD, Elbagir, S, Aledrissy, MIE, Elagib, EM, Nur, MAM, Weitoft, T, Rönnelid, J, Bioscience, T, Quintero, OL, Amador-Patarroyo, MJ, Montoya-Ortiz, G, Rojas-Villarraga, A, Anaya, JM, Shelly, S, Boaz, M, Orbach, H, Agarwal, SK, Wheeler, MJ, Lashkari, M, Noori, A, Oveisi, S, Kheirkhah, M, Diseases, M, Health, C, Diseases, M, Diseases, M, Engdahl, C, Bondt, A, Harre, U, Raufer, J, Pfeifle, R, Camponeschi, A, Wuhrer, M, Seeling, M, Mårtensson, IL, Nimmerjahn, F, Krönke, G, Scherer, HU, Forsblad-d'Elia, H, Schett, G, Pierdominici, M, Maselli, A, Colasanti, T, Giammarioli, AM, Delunardo, F, Vacirca, D, Sanchez, M, Giovannetti, A, Malorni, W, Ortona, E, Provost, M, Eaton, JL, Clowse, MEB, Brouwer, J, Hazes, JMW, Laven, JSE, Dolhain, RJEM, de Jong, PHP & Dolhain, RJEM 2018, 'Sex Hormones and Rheumatoid Factor : a Possible Link Between Reproductive Hormones Patterns and the Onset of Rheumatoid Arthritis Among Women in', Current Opinion in Rheumatology, pp. 1467-1476. https://doi.org/10.1016/j.jaut.2009.11.015%0Ahttp://www.ncbi.nlm.nih.gov/pubmed/31507122%0Ahttp://dx.doi.org/10.1016/j.cellimm.2015.02.004%0Ahttp://biostor.org/reference/128533%0Ahttp://dx.doi.org/10.1038/nrrheum.2014.144%0Ahttps://doi.org/10.1007/s4074

Sex Hormones and Rheumatoid Factor : a Possible Link Between Reproductive Hormones Patterns and the Onset of Rheumatoid Arthritis Among Women in. / Aletaha, Daniel; Neogi, Tuhina; Silman, Alan J.; Funovits, Julia; Felson, David T.; Bingham, Clifton O.; Birnbaum, Neal S.; Burmester, Gerd R.; Bykerk, Vivian P.; Cohen, Marc D.; Combe, Bernard; Costenbader, Karen H.; Dougados, Maxime; Emery, Paul; Ferraccioli, Gianfranco; Hazes, Johanna M.W.; Hobbs, Kathryn; Huizinga, Tom W.J.; Kavanaugh, Arthur; Kay, Jonathan; Kvien, Tore K.; Laing, Timothy; Mease, Philip; Ménard, Henri A.; Moreland, Larry W.; Naden, Raymond L.; Pincus, Theodore; Smolen, Josef S.; Stanislawska-Biernat, Ewa; Symmons, Deborah; Tak, Paul P.; Upchurch, Katherine S.; Vencovský, Jiří; Wolfe, Frederick; Hawker, Gillian; Elshafie, Amir I.; Elkhalifa, Abdalla D.; Elbagir, Sahwa; Aledrissy, Mawahib I.E.; Elagib, Elnour M.; Nur, Musa A.M.; Weitoft, Tomas; Rönnelid, Johan; Bioscience, Tosoh; Quintero, Olga L.; Amador-Patarroyo, Manuel J.; Montoya-Ortiz, Gladys; Rojas-Villarraga, Adriana; Anaya, Juan Manuel; Shelly, Shahar; Boaz, Mona; Orbach, Hedi; Agarwal, Sandeep K.; Wheeler, Michael J; Lashkari, Mahin; Noori, Akram; Oveisi, Sonia; Kheirkhah, Mohammadreza; Diseases, Metabolic; Health, Child; Diseases, Metabolic; Diseases, Metabolic; Engdahl, Cecilia; Bondt, Albert; Harre, Ulrike; Raufer, Jasmin; Pfeifle, René; Camponeschi, Alessandro; Wuhrer, Manfred; Seeling, Michaela; Mårtensson, Inga Lill; Nimmerjahn, Falk; Krönke, Gerhard; Scherer, Hans U.; Forsblad-d'Elia, Helena; Schett, Georg; Pierdominici, Marina; Maselli, Angela; Colasanti, Tania; Giammarioli, Anna Maria; Delunardo, Federica; Vacirca, Davide; Sanchez, Massimo; Giovannetti, Antonello; Malorni, Walter; Ortona, Elena; Provost, Meredith; Eaton, Jennifer L.; Clowse, Megan E.B.; Brouwer, Jenny; Hazes, Johanna M.W.; Laven, Joop S.E.; Dolhain, Radboud J.E.M.; de Jong, Pascal H.P.; Dolhain, Radboud J.E.M.

In: Current Opinion in Rheumatology, 2018, p. 1467-1476.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Sex Hormones and Rheumatoid Factor : a Possible Link Between Reproductive Hormones Patterns and the Onset of Rheumatoid Arthritis Among Women in

AU - Aletaha, Daniel

AU - Neogi, Tuhina

AU - Silman, Alan J.

AU - Funovits, Julia

AU - Felson, David T.

AU - Bingham, Clifton O.

AU - Birnbaum, Neal S.

AU - Burmester, Gerd R.

AU - Bykerk, Vivian P.

AU - Cohen, Marc D.

AU - Combe, Bernard

AU - Costenbader, Karen H.

AU - Dougados, Maxime

AU - Emery, Paul

AU - Ferraccioli, Gianfranco

AU - Hazes, Johanna M.W.

AU - Hobbs, Kathryn

AU - Huizinga, Tom W.J.

AU - Kavanaugh, Arthur

AU - Kay, Jonathan

AU - Kvien, Tore K.

AU - Laing, Timothy

AU - Mease, Philip

AU - Ménard, Henri A.

AU - Moreland, Larry W.

AU - Naden, Raymond L.

AU - Pincus, Theodore

AU - Smolen, Josef S.

AU - Stanislawska-Biernat, Ewa

AU - Symmons, Deborah

AU - Tak, Paul P.

AU - Upchurch, Katherine S.

AU - Vencovský, Jiří

AU - Wolfe, Frederick

AU - Hawker, Gillian

AU - Elshafie, Amir I.

AU - Elkhalifa, Abdalla D.

AU - Elbagir, Sahwa

AU - Aledrissy, Mawahib I.E.

AU - Elagib, Elnour M.

AU - Nur, Musa A.M.

AU - Weitoft, Tomas

AU - Rönnelid, Johan

AU - Bioscience, Tosoh

AU - Quintero, Olga L.

AU - Amador-Patarroyo, Manuel J.

AU - Montoya-Ortiz, Gladys

AU - Rojas-Villarraga, Adriana

AU - Anaya, Juan Manuel

AU - Shelly, Shahar

AU - Boaz, Mona

AU - Orbach, Hedi

AU - Agarwal, Sandeep K.

AU - Wheeler, Michael J

AU - Lashkari, Mahin

AU - Noori, Akram

AU - Oveisi, Sonia

AU - Kheirkhah, Mohammadreza

AU - Diseases, Metabolic

AU - Health, Child

AU - Diseases, Metabolic

AU - Engdahl, Cecilia

AU - Bondt, Albert

AU - Harre, Ulrike

AU - Raufer, Jasmin

AU - Pfeifle, René

AU - Camponeschi, Alessandro

AU - Wuhrer, Manfred

AU - Seeling, Michaela

AU - Mårtensson, Inga Lill

AU - Nimmerjahn, Falk

AU - Krönke, Gerhard

AU - Scherer, Hans U.

AU - Forsblad-d'Elia, Helena

AU - Schett, Georg

AU - Pierdominici, Marina

AU - Maselli, Angela

AU - Colasanti, Tania

AU - Giammarioli, Anna Maria

AU - Delunardo, Federica

AU - Vacirca, Davide

AU - Sanchez, Massimo

AU - Giovannetti, Antonello

AU - Malorni, Walter

AU - Ortona, Elena

AU - Provost, Meredith

AU - Eaton, Jennifer L.

AU - Clowse, Megan E.B.

AU - Brouwer, Jenny

AU - Hazes, Johanna M.W.

AU - Laven, Joop S.E.

AU - Dolhain, Radboud J.E.M.

AU - de Jong, Pascal H.P.

AU - Dolhain, Radboud J.E.M.

PY - 2018

Y1 - 2018

N2 - Many rheumatic diseases affect women of childbearing age, and the medications used to treat these diseases may affect conception, pregnancy, fetal development, and lactation. Physicians who care for these women need to be aware of the potential adverse effects of these medications, and which medications can be used safely prior to conception and during pregnancy and lactation. Although reviews of individual classes of medications are available, there is no practical and comprehensive review that summarizes all of this information, and includes anticoagulant drugs and 2 recently approved drugs for rheumatoid arthritis. Women who take cytotoxic drugs should be informed of the risks of impaired fertility and congenital malformations, and must use effective methods of contraception. During pregnancy, nonsteroidal anti-inflammatory agents may be used until the last 6 weeks, and low to moderate doses of corticosteroids are safe throughout pregnancy. Among the disease-modifying agents, sulfasalazine and hydroxychloroquine treatment may be maintained. Cytotoxic drugs may be used after the first trimester to treat life-threatening disease. During lactation, prednisone, sulfasalazine, and hydroxychloroquine may be used cautiously. Women using heparin for treatment of antiphospholipid antibody syndrome should take measures to prevent bone loss. Men taking methotrexate, sulfasalazine, cyclosporine, azathioprine, or leflunomide should be apprised of the possibilities of infertility and teratogenicity.

AB - Many rheumatic diseases affect women of childbearing age, and the medications used to treat these diseases may affect conception, pregnancy, fetal development, and lactation. Physicians who care for these women need to be aware of the potential adverse effects of these medications, and which medications can be used safely prior to conception and during pregnancy and lactation. Although reviews of individual classes of medications are available, there is no practical and comprehensive review that summarizes all of this information, and includes anticoagulant drugs and 2 recently approved drugs for rheumatoid arthritis. Women who take cytotoxic drugs should be informed of the risks of impaired fertility and congenital malformations, and must use effective methods of contraception. During pregnancy, nonsteroidal anti-inflammatory agents may be used until the last 6 weeks, and low to moderate doses of corticosteroids are safe throughout pregnancy. Among the disease-modifying agents, sulfasalazine and hydroxychloroquine treatment may be maintained. Cytotoxic drugs may be used after the first trimester to treat life-threatening disease. During lactation, prednisone, sulfasalazine, and hydroxychloroquine may be used cautiously. Women using heparin for treatment of antiphospholipid antibody syndrome should take measures to prevent bone loss. Men taking methotrexate, sulfasalazine, cyclosporine, azathioprine, or leflunomide should be apprised of the possibilities of infertility and teratogenicity.

UR - https://www.mendeley.com/catalogue/b93e7f32-c45f-3573-81b8-9deaf4b279ed/

U2 - 10.1016/j.jaut.2009.11.015%0Ahttp://www.ncbi.nlm.nih.gov/pubmed/31507122%0Ahttp://dx.doi.org/10.1016/j.cellimm.2015.02.004%0Ahttp://biostor.org/reference/128533%0Ahttp://dx.doi.org/10.1038/nrrheum.2014.144%0Ahttps://doi.org/10.1007/s4074

DO - 10.1016/j.jaut.2009.11.015%0Ahttp://www.ncbi.nlm.nih.gov/pubmed/31507122%0Ahttp://dx.doi.org/10.1016/j.cellimm.2015.02.004%0Ahttp://biostor.org/reference/128533%0Ahttp://dx.doi.org/10.1038/nrrheum.2014.144%0Ahttps://doi.org/10.1007/s4074

M3 - Artículo

C2 - 10724046

SP - 1467

EP - 1476

JO - Current Opinion in Rheumatology

JF - Current Opinion in Rheumatology

SN - 1040-8711

ER -

Aletaha D, Neogi T, Silman AJ, Funovits J, Felson DT, Bingham CO et al. Sex Hormones and Rheumatoid Factor : a Possible Link Between Reproductive Hormones Patterns and the Onset of Rheumatoid Arthritis Among Women in. Current Opinion in Rheumatology. 2018;1467-1476. https://doi.org/10.1016/j.jaut.2009.11.015%0Ahttp://www.ncbi.nlm.nih.gov/pubmed/31507122%0Ahttp://dx.doi.org/10.1016/j.cellimm.2015.02.004%0Ahttp://biostor.org/reference/128533%0Ahttp://dx.doi.org/10.1038/nrrheum.2014.144%0Ahttps://doi.org/10.1007/s4074

Sex Hormones and Rheumatoid Factor : a Possible Link Between Reproductive Hormones Patterns and the Onset of Rheumatoid Arthritis Among Women in

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