NHP-immunome: A translational research-oriented database of non-human primate immune system proteins

David F. Plaza, Manuel F. Gómez, Manuel A. Patarroyo

Research output: Contribution to journalArticle

Abstract

We are currently living the advent of a new age for medicine in which basic research is being quickly translated into marketable drugs, and the widespread access to genomics data is allowing the design and implementation of personalized solutions to medical conditions. Non-human primates (NHP) have gained an essential role in drug discovery and safety testing due to their close phylogenetic relationship to humans. In this study, a collection of well characterized genes of the human immune system was used to define the orthology-based immunome in four NHP species, with carefully curated annotations available based on multi-tissue RNA-seq datasets. A broad variation in the frequency of expressed protein isoforms was observed between species. Finally, this analysis also revealed the lack of expression of at least four different chemokines in new-world primates. In addition, transcripts corresponding to four genes including interleukin 12 subunit alpha were expressed in humans but no other primate species analyzed. Access to the non-human primate immunome is available in http://www.fidic.org.co:90/proyecto/.

Original languageEnglish (US)
Article number103999
JournalCellular Immunology
Volume347
DOIs
StatePublished - Jan 2020

All Science Journal Classification (ASJC) codes

  • Immunology

Cite this

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abstract = "We are currently living the advent of a new age for medicine in which basic research is being quickly translated into marketable drugs, and the widespread access to genomics data is allowing the design and implementation of personalized solutions to medical conditions. Non-human primates (NHP) have gained an essential role in drug discovery and safety testing due to their close phylogenetic relationship to humans. In this study, a collection of well characterized genes of the human immune system was used to define the orthology-based immunome in four NHP species, with carefully curated annotations available based on multi-tissue RNA-seq datasets. A broad variation in the frequency of expressed protein isoforms was observed between species. Finally, this analysis also revealed the lack of expression of at least four different chemokines in new-world primates. In addition, transcripts corresponding to four genes including interleukin 12 subunit alpha were expressed in humans but no other primate species analyzed. Access to the non-human primate immunome is available in http://www.fidic.org.co:90/proyecto/.",
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NHP-immunome : A translational research-oriented database of non-human primate immune system proteins. / Plaza, David F.; Gómez, Manuel F.; Patarroyo, Manuel A.

In: Cellular Immunology, Vol. 347, 103999, 01.2020.

Research output: Contribution to journalArticle

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T2 - A translational research-oriented database of non-human primate immune system proteins

AU - Plaza, David F.

AU - Gómez, Manuel F.

AU - Patarroyo, Manuel A.

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