TY - JOUR
T1 - Inadequate glucose control in type 2 diabetes is associated with impaired lung function and systemic inflammation
T2 - A cross-sectional study
AU - Dennis, Rodolfo J.
AU - Maldonado, Dario
AU - Rojas, Maria X.
AU - Aschner, Pablo
AU - Rondón, Martin
AU - Charry, Laura
AU - Casas, Alejandro
N1 - Funding Information:
This study was made possible by funding from COLCIENCIAS, Colombia, Code 2239-04-16300. An abstract of the full study was presented at the European Respiratory Society 19thannual congress, Vienna, September 2009. We are indebted to Maria Esguerra, Andrea Fonseca, Rubby Guanes and Martha Rios, for their unstinting work in all study procedures, and to Hector Restrepo, epidemiologist, for his work in data cleaning, management, and analysis. We also thank Carlos Torres MD, for his review of a previous version of this manuscript.
PY - 2010/7/26
Y1 - 2010/7/26
N2 - Background: Inadequate glucose control may be simultaneously associated with inflammation and decreased lung function in type 2 diabetes. We evaluated if lung function is worse in patients with inadequate glucose control, and if inflammatory markers are simultaneously increased in these subjects.Methods: Subjects were selected at the Colombian Diabetes Association Center in Bogotá. Pulmonary function tests were performed and mean residual values were obtained for forced expiratory volume (FEV1), forced vital capacity (FVC) and FEV1/FVC, with predicted values based on those derived by Hankinson et al. for Mexican-Americans. Multiple least-squares regression was used to adjust for differences in known determinants of lung function. We measured blood levels of glycosylated hemoglobin (HBA1c), interleukin 6 (IL-6), tumor necrosis factor (TNF-α), fibrinogen, ferritin, and C-reactive protein (C-RP).Results: 495 diabetic patients were studied, out of which 352 had inadequate control (HBA1c > 7%). After adjusting for known determinants of lung function, those with inadequate control had lower FEV1 (-75.4 mL, IC95%: -92, -59; P < 0.0001) and FVC (-121 mL, IC95%: -134, -108; P < 0,0001) mean residuals, and higher FEV1/FVC (0.013%, IC95%: 0.009, 0.018, P < 0.0001) residuals than those with adequate control, as well as increased levels of all inflammatory markers (P < 0.05), with the exception of IL-6.Conclusions: Subjects with type 2 diabetes and inadequate control had lower FVC and FEV1 than predicted and than those of subjects with adequate control. It is postulated that poorer pulmonary function may be associated with increased levels of inflammatory mediators.
AB - Background: Inadequate glucose control may be simultaneously associated with inflammation and decreased lung function in type 2 diabetes. We evaluated if lung function is worse in patients with inadequate glucose control, and if inflammatory markers are simultaneously increased in these subjects.Methods: Subjects were selected at the Colombian Diabetes Association Center in Bogotá. Pulmonary function tests were performed and mean residual values were obtained for forced expiratory volume (FEV1), forced vital capacity (FVC) and FEV1/FVC, with predicted values based on those derived by Hankinson et al. for Mexican-Americans. Multiple least-squares regression was used to adjust for differences in known determinants of lung function. We measured blood levels of glycosylated hemoglobin (HBA1c), interleukin 6 (IL-6), tumor necrosis factor (TNF-α), fibrinogen, ferritin, and C-reactive protein (C-RP).Results: 495 diabetic patients were studied, out of which 352 had inadequate control (HBA1c > 7%). After adjusting for known determinants of lung function, those with inadequate control had lower FEV1 (-75.4 mL, IC95%: -92, -59; P < 0.0001) and FVC (-121 mL, IC95%: -134, -108; P < 0,0001) mean residuals, and higher FEV1/FVC (0.013%, IC95%: 0.009, 0.018, P < 0.0001) residuals than those with adequate control, as well as increased levels of all inflammatory markers (P < 0.05), with the exception of IL-6.Conclusions: Subjects with type 2 diabetes and inadequate control had lower FVC and FEV1 than predicted and than those of subjects with adequate control. It is postulated that poorer pulmonary function may be associated with increased levels of inflammatory mediators.
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U2 - 10.1186/1471-2466-10-38
DO - 10.1186/1471-2466-10-38
M3 - Article
C2 - 20659337
AN - SCOPUS:77954885721
SN - 1471-2466
VL - 10
JO - BMC Pulmonary Medicine
JF - BMC Pulmonary Medicine
M1 - 38
ER -
