Immunogenicity of Adalimumab in Patients with Non-Infectious- Uveitis: Systematic Review and Meta-Analysis

Diana Isabel Pachón-Suárez, Laura Zárate-Pinzón, Carlos Cifuentes-González, William Rojas-Carabali, Germán Mejía-Salgado, Juan Sebastián Pineda, Luisa Fernanda Peña-Pulgar, Alejandra de-la-Torre

Research output: Contribution to journalArticlepeer-review


Objective: To review the prevalence, incidence, and risk factors for developing anti-drug antibodies (AAA) in patients with non-infectious uveitis (NIU) treated with Adalimumab (ADA). Methods: A systematic literature search was performed on PubMed, EMBASE, Virtual Health Library, Cochrane, and medRxiv. Meta-analysis was performed using random effects. Results: Nine out of 2,373 studies were included. The prevalence of AAA in NIU patients treated with ADA was 9% (95% CI: 2% to 37%, I2 = 95% with a P<0.01), it was significantly higher in real-life scenarios (observational studies) than in clinical trials. The pooled incidence at 12 months was 27% (CI 95% 16%-42% I2 = 0%). Several factors have been associated with AAA generation in NIU patients, including the non-use of concomitant immunosuppressants, presence of autoimmune systemic disease, female gender, etc. Conclusion: This study showed that AAA prevalence is higher in real-life scenarios compared to clinical trials. Further research is needed to elucidate the factors that trigger AAA generation in NIU patients.

Original languageEnglish (US)
JournalOcular Immunology and Inflammation
StateAccepted/In press - 2023

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Ophthalmology


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