Genetic associations of leptin-related polymorphisms with systemic lupus erythematosus

doi:10.1016/j.clim.2015.09.007

Genetic associations of leptin-related polymorphisms with systemic lupus erythematosus

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Abstract

Leptin is abnormally elevated in the plasma of patients with systemic lupus erythematosus (SLE), where it is thought to promote and/or sustain pro-inflammatory responses. Whether this association could reflect an increased genetic susceptibility to develop SLE is not known, and studies of genetic associations with leptin-related polymorphisms in SLE patients have been so far inconclusive. Here we genotyped DNA samples from 15,706 SLE patients and healthy matched controls from four different ancestral groups, to correlate polymorphisms of genes of the leptin pathway to risk for SLE. It was found that although several SNPs showed weak associations, those associations did not remain significant after correction for multiple testing. These data do not support associations between defined leptin-related polymorphisms and increased susceptibility to develop SLE.

Original language	English (US)
Pages (from-to)	157-162
Number of pages	6
Journal	Clinical Immunology
Volume	161
Issue number	2
DOIs	https://doi.org/10.1016/j.clim.2015.09.007
State	Published - Dec 1 2015

All Science Journal Classification (ASJC) codes

Immunology and Allergy
Immunology

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10.1016/j.clim.2015.09.007

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@article{cd461eb0bcee495da127f39b996c62d6,

title = "Genetic associations of leptin-related polymorphisms with systemic lupus erythematosus",

abstract = "Leptin is abnormally elevated in the plasma of patients with systemic lupus erythematosus (SLE), where it is thought to promote and/or sustain pro-inflammatory responses. Whether this association could reflect an increased genetic susceptibility to develop SLE is not known, and studies of genetic associations with leptin-related polymorphisms in SLE patients have been so far inconclusive. Here we genotyped DNA samples from 15,706 SLE patients and healthy matched controls from four different ancestral groups, to correlate polymorphisms of genes of the leptin pathway to risk for SLE. It was found that although several SNPs showed weak associations, those associations did not remain significant after correction for multiple testing. These data do not support associations between defined leptin-related polymorphisms and increased susceptibility to develop SLE.",

author = "Jian Zhao and Hui Wu and Langefeld, {Carl D.} and Kaufman, {Kenneth M.} and Kelly, {Jennifer A.} and Bae, {Sang Cheol} and Alarc{\'o}n-Riquelme, {Marta E.} and Alarc{\'o}n, {Graciela S.} and Anaya, {Juan Manuel} and Criswell, {Lindsey A.} and Freedman, {Barry I.} and Kamen, {Diane L.} and Gilkeson, {Gary S.} and Jacob, {Chaim O.} and James, {Judith A.} and Merrill, {Joan T.} and Gaffney, {Patrick M.} and Sivils, {Kathy Moser} and Niewold, {Timothy B.} and Petri, {Michelle A.} and Song, {Seung Taek} and Jeong, {Hye jin} and Rosalind Ramsey-Goldman and Reveille, {John D.} and {Hal Scofield}, R. and Stevens, {Anne M.} and Boackle, {Susan A.} and Vil{\'a}, {Luis M.} and Chang, {Deh Ming} and Song, {Yeong Wook} and Vyse, {Timothy J.} and Harley, {John B.} and Brown, {Elizabeth E.} and Edberg, {Jeffrey C.} and Kimberly, {Robert P.} and Hahn, {Bevra H.} and Grossman, {Jennifer M.} and Tsao, {Betty P.} and {La Cava}, Antonio and Johan Frosteg{\aa}rd and Lennart Truedsson and {de Ram{\'o}n}, Enrique and Sabio, {Jos{\'e} M.} and Gonz{\'a}lez-Escribano, {Mar{\'i}a F.} and Javier Martin and Norberto Ortego-Centeno and Callejas, {Jos{\'e} Luis} and Julio S{\'a}nchez-Rom{\'a}n and Sandra D'Alfonso and Sergio Migliarese",

year = "2015",

month = dec,

day = "1",

doi = "10.1016/j.clim.2015.09.007",

language = "English (US)",

volume = "161",

pages = "157--162",

journal = "Clinical Immunology",

issn = "1521-6616",

publisher = "Academic Press Inc.",

number = "2",

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TY - JOUR

T1 - Genetic associations of leptin-related polymorphisms with systemic lupus erythematosus

AU - Zhao, Jian

AU - Wu, Hui

AU - Langefeld, Carl D.

AU - Kaufman, Kenneth M.

AU - Kelly, Jennifer A.

AU - Bae, Sang Cheol

AU - Alarcón-Riquelme, Marta E.

AU - Alarcón, Graciela S.

AU - Anaya, Juan Manuel

AU - Criswell, Lindsey A.

AU - Freedman, Barry I.

AU - Kamen, Diane L.

AU - Gilkeson, Gary S.

AU - Jacob, Chaim O.

AU - James, Judith A.

AU - Merrill, Joan T.

AU - Gaffney, Patrick M.

AU - Sivils, Kathy Moser

AU - Niewold, Timothy B.

AU - Petri, Michelle A.

AU - Song, Seung Taek

AU - Jeong, Hye jin

AU - Ramsey-Goldman, Rosalind

AU - Reveille, John D.

AU - Hal Scofield, R.

AU - Stevens, Anne M.

AU - Boackle, Susan A.

AU - Vilá, Luis M.

AU - Chang, Deh Ming

AU - Song, Yeong Wook

AU - Vyse, Timothy J.

AU - Harley, John B.

AU - Brown, Elizabeth E.

AU - Edberg, Jeffrey C.

AU - Kimberly, Robert P.

AU - Hahn, Bevra H.

AU - Grossman, Jennifer M.

AU - Tsao, Betty P.

AU - La Cava, Antonio

AU - Frostegård, Johan

AU - Truedsson, Lennart

AU - de Ramón, Enrique

AU - Sabio, José M.

AU - González-Escribano, María F.

AU - Martin, Javier

AU - Ortego-Centeno, Norberto

AU - Callejas, José Luis

AU - Sánchez-Román, Julio

AU - D'Alfonso, Sandra

AU - Migliarese, Sergio

PY - 2015/12/1

Y1 - 2015/12/1

N2 - Leptin is abnormally elevated in the plasma of patients with systemic lupus erythematosus (SLE), where it is thought to promote and/or sustain pro-inflammatory responses. Whether this association could reflect an increased genetic susceptibility to develop SLE is not known, and studies of genetic associations with leptin-related polymorphisms in SLE patients have been so far inconclusive. Here we genotyped DNA samples from 15,706 SLE patients and healthy matched controls from four different ancestral groups, to correlate polymorphisms of genes of the leptin pathway to risk for SLE. It was found that although several SNPs showed weak associations, those associations did not remain significant after correction for multiple testing. These data do not support associations between defined leptin-related polymorphisms and increased susceptibility to develop SLE.

AB - Leptin is abnormally elevated in the plasma of patients with systemic lupus erythematosus (SLE), where it is thought to promote and/or sustain pro-inflammatory responses. Whether this association could reflect an increased genetic susceptibility to develop SLE is not known, and studies of genetic associations with leptin-related polymorphisms in SLE patients have been so far inconclusive. Here we genotyped DNA samples from 15,706 SLE patients and healthy matched controls from four different ancestral groups, to correlate polymorphisms of genes of the leptin pathway to risk for SLE. It was found that although several SNPs showed weak associations, those associations did not remain significant after correction for multiple testing. These data do not support associations between defined leptin-related polymorphisms and increased susceptibility to develop SLE.

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U2 - 10.1016/j.clim.2015.09.007

DO - 10.1016/j.clim.2015.09.007

M3 - Research Article

C2 - 26385092

AN - SCOPUS:84942900473

SN - 1521-6616

VL - 161

SP - 157

EP - 162

JO - Clinical Immunology

JF - Clinical Immunology

IS - 2

ER -

Genetic associations of leptin-related polymorphisms with systemic lupus erythematosus

Abstract

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